DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2701 and Ascc2

DIOPT Version :9

Sequence 1:	NP_570025.1	Gene:	CG2701 / 31261	FlyBaseID:	FBgn0024973	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001102561.1	Gene:	Ascc2 / 498402	RGDID:	1561422	Length:	749	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	221/807 - (27%)
Similarity:	370/807 - (45%)	Gaps:	152/807 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LPLDELKFALSGKD---GVRRNVPAL------DEHWVQREKPFASYLCMLSSYGRLKSGAALEEW 72
            ||||:|:  ::.||   |..|...||      |.::|..:.|....:           .|.:||:
  Rat     4 LPLDQLQ--ITHKDPKTGKLRTSAALHPEQKADRYFVLYKPPPKDNI-----------PALVEEY 55

  Fly    73 TFAANNFRGDMEFLLSLTQHEFWSYMVYDESAMAAVVTFL----QRANPYYRQTDVSRDKELDQA 133
            ...||....|:::||:|...:||..:::|||....:.::|    ::.:.:...|....|.   |.
  Rat    56 LERANFVANDLDWLLALPHDKFWCQVIFDESLQKCLDSYLHYVPRKFDEWVAPTPEVADM---QK 117

  Fly   134 HLLYGQLLDLVVRLIMRLCTGKESDSEWISPKQHGSLLYSNYLISVPLLFDLLIAVGDAEPENVE 198
            ||.....|     ..:|:.|.|||...:|||...|.:||:|:|..:|.:.||.:..|..   |..
  Rat   118 HLHRSVFL-----TFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKG---NSP 174

  Fly   199 LLRQIFDKVLEVQPEYQKDLKEALIFYESAFLSMQIQVENEGCEGAGGGASLDVDLE-----TPY 258
            ||:::...:...||.|..||.|.:......|.::   :::.|.:|.|.. ::...|.     ||.
  Rat   175 LLQKMIGNIFTQQPSYYNDLDETIPTILQVFSNI---LQHCGLQGDGIN-TIPQKLGERPRLTPS 235

  Fly   259 D-------DVVLFAMDCAYTLRLLLLLCPQLLETIEQLRLAPSIANFYDMTVPMLYKNIYLVNPG 316
            |       |:||:..|.:.||...|.:.|...:|.::......:|:||:|.:|.:...|......
  Rat   236 DMPLLELKDIVLYLCDTSTTLWAFLDIFPLACQTFQKHDFCYRLASFYEMAIPEIESAIKKRRLE 300

  Fly   317 ASSL---RW--LNETRQQYIFIVRRVV-----------SLQMESGRGQQLVEVMQECLSAQNFVV 365
            .|.|   .|  |:.::::.:.:...::           |.....|..::.:::....|..:.|:.
  Rat   301 DSKLLGDMWQRLSHSKKKLMEVFHTILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLR 365

  Fly   366 DYQRQFPLEHDMKLLIQRCPNIKNYEVDFVVSGYQKA--------LASCPNGIMADDMASNGVQV 422
            ||...||:..|:.||.|....:......:::...:.|        :....:...|.| ::|||.:
  Rat   366 DYDSFFPVAEDISLLQQASSALDETRTTYILQAVEGAWEGVDRQKIKDIKDPSRAKD-SNNGVTM 429

  Fly   423 TG-----------NVQDEEFKNGDSSRTSPQPSPTANGTTRDIDLEVTAVLEVLPDLGSGFIRRL 476
            |.           |.:|:|...|.::...|..|..      ::|..::.|.::|||||.|||...
  Rat   430 TAEPVSEMPSQLENSEDDEECMGAAAAVGPAVSGV------ELDSLISQVKDLLPDLGEGFILAC 488

  Fly   477 LIRYD-NSEQVIAAILDDNLPPDLAQMDRQ-EVYIPPDPQDKQQRQTGL---RHFNVHDGDRYDV 536
            |..|. :||:||..||:|.|.|:|:|:||. |..:.|||       |.|   || ||...|.:||
  Rat   489 LEHYSYDSERVINNILEDRLAPELSQLDRSLERQVKPDP-------TPLLSSRH-NVFQNDEFDV 545

  Fly   537 LTRDQPECIIKQGKGLPGAPRNAEQ----LLDDKRDLKQLKERYQKYA-MVEETTLERGE----- 591
            .:||..: :.:..||     |..|:    |::||:.:....:|||||: :|||..|:.||
  Rat   546 FSRDSVD-LSRVHKG-----RRKEETVRSLVNDKQAVVAQWQRYQKYSVIVEEVPLQPGEYQADD 604

  Fly   592 YDDEYDDSYEAQNEGQAPPVS--------------LLRGRLQEAASSSAYNAQDELENDDEESSG 642
            |:|||||:|:....|.....|              :||.::.........:.:||:|   ||:
  Rat   605 YEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKMPVEGQEEECDEEDEVE---EEA-- 664

  Fly   643 GHSDPEPSMRTNRDFCENPEVIRARYEQRQLSKYGQKSGGHGASPSVVGAPKGQGQSQQTQRSRG 707
                |:|.     .|.::|.|:|.:.|.|:::...:|......|.:|.|.|:|.|||::|.:.|.
  Rat   665 ----PKPD-----HFIQDPAVLREKAEARRIAFLARKGYRPENSTAVTGGPRGHGQSRETTQERR 720

  Fly   708 QKEAHKSTRANHNRKAGAAFKRSKGMM 734
            :|||:|:.||||:|:..|..||:|||:
  Rat   721 KKEANKAARANHSRRTMADRKRNKGMI 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2701	NP_570025.1	CUE_ASCC2	455..493	CDD:270547	18/38 (47%)
Ascc2	NP_001102561.1	CUE_ASCC2	467..506	CDD:270547	18/38 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346721
Domainoid	1	1.000	110	1.000	Domainoid score	I6204
eggNOG	1	0.900	-	-		E1_KOG4501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41774
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3500
OMA	1	1.010	-	-		QHG55054
OrthoDB	1	1.010	-	-		D311659at2759
OrthoFinder	1	1.000	-	-		FOG0007799
OrthoInspector	1	1.000	-	-		oto98623
orthoMCL	1	0.900	-	-		OOG6_105169
Panther	1	1.100	-	-	LDO	PTHR21494
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810