DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2685 and Wbp11

DIOPT Version :9

Sequence 1:	NP_570023.1	Gene:	CG2685 / 31259	FlyBaseID:	FBgn0024998	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001009661.1	Gene:	Wbp11 / 297695	RGDID:	1307911	Length:	641	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	235/685 - (34%)
Similarity:	329/685 - (48%)	Gaps:	177/685 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKKQRQMVRAAVLKNKDPSQILEEMEKIDEMEY 65
            |||||.::|||||:|||||||||||||:|||||||||.||||||||.|||.||:.:|||:||||:
  Rat     1 MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEF 65

  Fly    66 NVLQPSPLNEKVLRDKRKKLKETFDRVMRLYHNDEPEHWADLKRKEVEYEKKRLKKQQYYESVKH 130
            |.:|...||||||:||||||:|||:|::|||..:.|:.:.:|::.|||||:||.:..||:::||:
  Rat    66 NPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKN 130

  Fly   131 AQSVQIDEIPLPAPVSAVSG---------GSTETTGGSVVAGFGASVVIRLPPPPMTMALPPY-- 184
            ||.|:::.||||....|.|.         |:...:.....:.:|        ||...:::.|.
  Rat   131 AQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYG--------PPTRAVSILPLLG 187

  Fly   185 --APGAPPGVSRNSDLASEAQVEKSKENEQKDWLGVPPGPPP----------------------- 224
              .|..|||                     :...|.||||||
  Rat   188 HGVPRLPPG---------------------RKPPGPPPGPPPPQVLQMYGRKVGFALDLPPRRRD 231

  Fly   225 -DLFAFSELNSDAEGNTDYDGEGEEEEPEPLKKGKDKEKDKNSEATEPNNQNIDDFMKEMEHVHK 288
             |:....||..  .|:.|......|::..|    :|.::||:.::||.::.:..|...:.:..
  Rat   232 EDMLYSPELAQ--RGHDDDMSSTSEDDGYP----EDMDQDKHDDSTEDSDTDRSDAESDGDEF-- 288

  Fly   289 RKHRKLAAKEDEADKK---------------REEDDGKDIDKIE--------ERTSDSDKRTASS 330
             .||..:.:::..:||               :::.:.|::..::        :...:..:.....
  Rat   289 -GHRDDSERDNTEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEF 352

  Fly   331 TDDEDDDDQDEDE-------------------------NMPEVPTKPASVKSSTAT------PAP 364
            :::|||||.::.|                         ..|.....|:.:::....      |.|
  Rat   353 SEEEDDDDSEDSEAEKPSQKQHKEDSHADGSSAASSQQQAPPQAVPPSQIQAPPMPGPPPLGPPP 417

  Fly   365 APPTAPTLPTIPLPPASSVPAPPQL--PHLP----PIPNLGPPGIMYRPPPMRPPHPGSGFGIRM 423
            |||..|..|...|||.....|||.|  |.:|    |:|.|.|||    |||.|||.|..|....:
  Rat   418 APPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGIRGPLPRLLPPG----PPPGRPPGPPPGPPPGL 478

  Fly   424 PPGPPP-------GPRAPHGLGPIPRMGIRMPP-----GP-PPGL--------------PPRLAH 461
            ||||||       .|.||.|:.| ||.|:..||     || ||||              ||.|..
  Rat   479 PPGPPPRGPPPRLPPPAPPGIPP-PRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQ 542

  Fly   462 HNKQGGGAGAPKESAKGVATITAKPQIRNLSADVTRFVPSTLRVKREDQRRTARPRHAANDGHH- 525
            ..|....:.|..|. |..|||:|||||.|..|:||||||:.|||:||::..||.|:..:.:...
  Rat   543 RPKADDASAATIEK-KATATISAKPQITNPKAEVTRFVPTALRVRRENKGATAVPQRRSEEDSAV 606

  Fly   526 --AHSEAHSKP------PTKDDAYLQFMNEMQGLL 552
              |.:...|.|      .||||.|..||.||:|||
  Rat   607 PVAKAAPRSGPSVPVSVQTKDDVYEAFMKEMEGLL 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2685	NP_570023.1	Wbp11	12..92	CDD:286512	61/79 (77%)
Wbp11	NP_001009661.1	Required for nuclear import. /evidence=ECO:0000250	1..45		37/43 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		30/35 (86%)
		Wbp11	12..92	CDD:286512	61/79 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..213		11/47 (23%)
		Interaction with PP1. /evidence=ECO:0000250	217..221		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..549		81/326 (25%)
		Interaction with PP1. /evidence=ECO:0000250	306..310		0/3 (0%)
		PGR	455..466		8/14 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..623		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3363
eggNOG	1	0.900	-	-		E1_KOG4672
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2397
OMA	1	1.010	-	-		QHG52681
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006094
OrthoInspector	1	1.000	-	-		oto96654
orthoMCL	1	0.900	-	-		OOG6_108290
Panther	1	1.100	-	-	LDO	PTHR13361
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5822
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.960