Protein Alignment CG2681 and SIAH2

DIOPT Version :9

• Sequence 1: NP_570022.2
• Gene: CG2681 / 31258
• FlyBaseID: FBgn0024997
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_005058.3
• Gene: SIAH2 / 6478
• HGNCID: 10858
• Length: 324
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 85/291 - (29%)
• Similarity: 119/291 - (40%)
• Gaps: 47/291 - (16%)

  Fly   113 ATLPSPNVVTLRSPLS--PPPKPPMLGRTRSTGPADGKGPASNGALSPDSSIIRQSFPEGVITPS 175
            :|.||.|     .|.|  |||:|     ..:..||.....|:..|..|.||.:    |......|
Human     6 STGPSAN-----KPCSKQPPPQP-----QHTPSPAAPPAAATISAAGPGSSAV----PAAAAVIS 56

  Fly   176 KPEKSPATPSEEGPPTVSARHYEGLIEELRCPGCAGAMKAPILLCKSGHSVCEQCTRILLMCPLC 240
                .|......||  ||.:|:| |.....||.|...:..|||.|::||.||.||.:.|..||.|
Human    57 ----GPGGGGGAGP--VSPQHHE-LTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTC 114

  Fly   241 KEPFTNS-RSLTVEALCAKAHFRCGHASGGCQVRMPVVLLPWHEQQCMYKPMKC-FMGRVWGDCR 303
            :...|.| |:|.:|.:.:...|.|.:|:.||.:.:.....|.||..|.|:|..| ..|   ..|:
Human   115 RGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPG---ASCK 176

  Fly   304 WQGREVQWKEHLEEQH--------DDRLFRSSSADL----EWNLGTRRKPLTGYYVFQAHDEMFN 356
            |||.......||...|        :|.:|.::..:|    :|   ...:...|:: |....|...
Human   177 WQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDW---VMMQSCFGHH-FMLVLEKQE 237

  Fly   357 FYEIHDRQRVLFTMTCTSNRRDSKYNFAYEV 387
            .||.|.:   .|.:......|....||||.:
Human   238 KYEGHQQ---FFAIVLLIGTRKQAENFAYRL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2681	NP_570022.2	RING	206..244	CDD:238093	17/37 (46%)
		Sina	248..442	CDD:281181	39/153 (25%)
SIAH2	NP_005058.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		14/45 (31%)
		RING-HC_SIAH2	78..115	CDD:319666	16/36 (44%)
		Sina	122..318	CDD:397316	39/154 (25%)
		SBD. /evidence=ECO:0000250|UniProtKB:P61092	130..322		36/146 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870