Protein Alignment CG2681 and SIAH2

DIOPT Version :10

• Sequence 1: NP_570022.2
• Gene: CG2681 / 31258
• FlyBaseID: FBgn0024997
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_005058.3
• Gene: SIAH2 / 6478
• HGNCID: 10858
• Length: 324
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 85/291 - (29%)
• Similarity: 119/291 - (40%)
• Gaps: 47/291 - (16%)

  Fly   113 ATLPSPNVVTLRSPLS--PPPKPPMLGRTRSTGPADGKGPASNGALSPDSSIIRQSFPEGVITPS 175
            :|.||.|     .|.|  |||:|     ..:..||.....|:..|..|.||.:    |......|
Human     6 STGPSAN-----KPCSKQPPPQP-----QHTPSPAAPPAAATISAAGPGSSAV----PAAAAVIS 56

  Fly   176 KPEKSPATPSEEGPPTVSARHYEGLIEELRCPGCAGAMKAPILLCKSGHSVCEQCTRILLMCPLC 240
                .|......||  ||.:|:| |.....||.|...:..|||.|::||.||.||.:.|..||.|
Human    57 ----GPGGGGGAGP--VSPQHHE-LTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTC 114

  Fly   241 KEPFTNS-RSLTVEALCAKAHFRCGHASGGCQVRMPVVLLPWHEQQCMYKPMKC-FMGRVWGDCR 303
            :...|.| |:|.:|.:.:...|.|.:|:.||.:.:.....|.||..|.|:|..| ..|   ..|:
Human   115 RGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPG---ASCK 176

  Fly   304 WQGREVQWKEHLEEQH--------DDRLFRSSSADL----EWNLGTRRKPLTGYYVFQAHDEMFN 356
            |||.......||...|        :|.:|.::..:|    :|   ...:...|:: |....|...
Human   177 WQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDW---VMMQSCFGHH-FMLVLEKQE 237

  Fly   357 FYEIHDRQRVLFTMTCTSNRRDSKYNFAYEV 387
            .||.|.:   .|.:......|....||||.:
Human   238 KYEGHQQ---FFAIVLLIGTRKQAENFAYRL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2681	NP_570022.2	RING_Ubox	206..250	CDD:473075	20/44 (45%)
		Sina	248..442	CDD:460824	39/153 (25%)
SIAH2	NP_005058.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		14/45 (31%)
		RING-HC_SIAH2	75..125	CDD:438410	20/49 (41%)
		Sina	122..318	CDD:460824	39/154 (25%)
		SBD. /evidence=ECO:0000250|UniProtKB:P61092	130..322		36/146 (25%)