Protein Alignment CG2681 and SIAH1

DIOPT Version :9

• Sequence 1: NP_570022.2
• Gene: CG2681 / 31258
• FlyBaseID: FBgn0024997
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001006611.1
• Gene: SIAH1 / 6477
• HGNCID: 10857
• Length: 313
• Species: Homo sapiens
• Alignment Length: 231
• Identity: 65/231 - (28%)
• Similarity: 97/231 - (41%)
• Gaps: 32/231 - (13%)

  Fly   174 PSKPEKSPATPSEEGP----PTVSARHYEGLIEELRCPGCAGAMKAPILLCKSGHSVCEQCTRIL 234
            |:...|.|  ||:..|    .|.|......|.|   ||.|...:..|||.|:|||.||..|...|
Human    41 PTGTSKCP--PSQRVPALTGTTASNNDLASLFE---CPVCFDYVLPPILQCQSGHLVCSNCRPKL 100

  Fly   235 LMCPLCKEPFTNSRSLTVEALCAKAHFRCGHASGGCQVRMPVVLLPWHEQQCMYKPMKC-FMGRV 298
            ..||.|:.|..:.|:|.:|.:.....|.|.:||.||::.:|......||:.|.::|..| ..|
Human   101 TCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG-- 163

  Fly   299 WGDCRWQGREVQWKEHLEEQH--------DDRLFRSSSADL----EWNLGTRRKPLTGYYVFQAH 351
             ..|:|||.......||..||        :|.:|.::..:|    :|   ...:...|::.....
Human   164 -ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDW---VMMQSCFGFHFMLVL 224

  Fly   352 DEMFNFYEIHDRQRVLFTMTCTSNRRDSKYNFAYEV 387
            ::.    |.:|..:..|.:......|....||||.:
Human   225 EKQ----EKYDGHQQFFAIVQLIGTRKQAENFAYRL 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2681	NP_570022.2	RING	206..244	CDD:238093	17/37 (46%)
		Sina	248..442	CDD:281181	37/153 (24%)
SIAH1	NP_001006611.1	RING-HC_SIAH1	70..109	CDD:319665	18/41 (44%)
		RING-HC finger (C3HC4-type)	72..106	CDD:319665	16/33 (48%)
		Sina	113..309	CDD:367355	37/154 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1969
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870