DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2681 and siah2l

DIOPT Version :9

Sequence 1:	NP_570022.2	Gene:	CG2681 / 31258	FlyBaseID:	FBgn0024997	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_956721.2	Gene:	siah2l / 378728	ZFINID:	ZDB-GENE-030922-1	Length:	330	Species:	Danio rerio

Alignment Length:	315	Identity:	79/315 - (25%)
Similarity:	128/315 - (40%)	Gaps:	44/315 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 GRTRSTGPADGKGPASNGALSPDSSIIRQSFPEGVITPSKPEKSPATPSEEGP---PTVSARHYE 198
            |.|.::..|.....|:..|.:..:.:.......|.:    |..:.|.|....|   |.::|
Zfish    28 GGTTASAAAAAAAAAAAAAAAAAAGVSGSVAGSGTV----PAAAVALPVAALPGQSPELTA---- 84

  Fly   199 GLIEELRCPGCAGAMKAPILLCKSGHSVCEQCTRILLMCPLCKEPFTNS-RSLTVEALCAKAHFR 262
             |.|   ||.|...:..|||.|::||.||.||.:.|..||.|:.|.|.| |:|.:|.:.:...|.
Zfish    85 -LFE---CPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGPLTPSIRNLAMEKVASTLPFP 145

  Fly   263 CGHASGGCQVRMPVVLLPWHEQQCMYKPMKC-FMGRVWGDCRWQGREVQWKEHLEEQH------- 319
            |.::|.||.:.:.....|.||:.|.::|..| ..|   ..|:|||...:...||...|
Zfish   146 CKYSSAGCLLSLHHSEKPEHEEVCEFRPYTCPCPG---ASCKWQGSLEEVMPHLMHAHKSITTLQ 207

  Fly   320 -DDRLFRSSSADL----EWNLGTRRKPLTGYYVFQAHDEMFNFYEIHDRQRVLFTMTCTSNRRDS 379
             :|.:|.::..:|    :|   ...:...|:: |....|....||.|.:   .|.:......|..
Zfish   208 GEDIVFLATDINLPGAVDW---VMMQSCFGHH-FMLVLEKQEKYEGHQQ---FFAIVLLIGTRKQ 265

  Fly   380 KYNFAYEVTVLLPDNEALSMTQKFPVHSEYD--KDILMEGTCVSIPLTELNRFLD 432
            ..||||.:.:   :.....:|.:....|.:|  ...:|...|:....:..:.|.|
Zfish   266 AENFAYRLEL---NGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTSIAHLFAD 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2681	NP_570022.2	RING	206..244	CDD:238093	17/37 (46%)
CG2681	NP_570022.2	Sina	248..442	CDD:281181	45/200 (23%)
siah2l	NP_956721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sina	130..326	CDD:281181	45/201 (22%)
		SBD	138..330		42/193 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D780610at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920