Protein Alignment eIF2Bbeta and EIF2B2

DIOPT Version :9

• Sequence 1: NP_570020.1
• Gene: eIF2Bbeta / 31256
• FlyBaseID: FBgn0024996
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_055054.1
• Gene: EIF2B2 / 8892
• HGNCID: 3258
• Length: 351
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 164/348 - (47%)
• Similarity: 235/348 - (67%)
• Gaps: 15/348 - (4%)

  Fly     8 EITQLIHAIKVGLVEG-----SYNITNKTLDIFKYIIMSKSWQNADALMQIVRDQCKILQAALPQ 67
            |:::.|.:....|..|     |..:..:||.:.:.||....|.||..||:::|.:.:.:.||.|.
Human    10 ELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPS 74

  Fly    68 ETVTSNIARRILKLTREEFDLLHAKVQHFADDSQASLSLHKLVTQTSESNVSVDYSVPQHGLREA 132
            ||...|:.||:||:.|||:..||.:    :|:|....|||||:|   ...::.|:|.....|:..
Human    75 ETTVGNMVRRVLKIIREEYGRLHGR----SDESDQQESLHKLLT---SGGLNEDFSFHYAQLQSN 132

  Fly   133 LLDHLQEVETELETSSENICVQAEEHIHSSEIILTLGHSRSVENFLKRAIKKRQFLTIIVAECAP 197
            :::.:.|:..|||.:.|||..||.|||||:|:|:|:|.||:||.|||.|.:||:| .:|||||||
Human   133 IIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKF-HVIVAECAP 196

  Fly   198 ACRGHNLAASLANEKNVEIVVIPDAAIFAMMSRVNKVIIGTHSVLANGGLRAACGAYTVALAAKH 262
            .|:||.:|.:| ::..:|..|:.||||||:|||||||||||.::||||.|||..|.:|:||||||
Human   197 FCQGHEMAVNL-SKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKH 260

  Fly   263 YSVPVIVLAPMYKLSPLHLCEQDAFNMVGCAEDVIPY-DSIPAREAKVYSPMFDYVPPELVTLFI 326
            :|.|:||.|||:||||....|:|:|:.....|:|:|: :.....:..|:.|:||||||||:||||
Human   261 HSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFI 325

  Fly   327 SNTGGHAPSYVYRLLTELYHPED 349
            ||.||:||||:|||::|||||:|
Human   326 SNIGGNAPSYIYRLMSELYHPDD 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bbeta	NP_570020.1	GCD2	8..345	CDD:275543	159/342 (46%)
		IF-2B	21..334	CDD:279362	148/318 (47%)
EIF2B2	NP_055054.1	IF-2B	29..333	CDD:395798	147/312 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147862
Domainoid	1	1.000	279	1.000	Domainoid score	I1699
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6507
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2624
Isobase	1	0.950	-	0	Normalized mean entropy	S1701
OMA	1	1.010	-	-		QHG54382
OrthoDB	1	1.010	-	-		D396237at33208
OrthoFinder	1	1.000	-	-		FOG0005038
OrthoInspector	1	1.000	-	-		oto88576
orthoMCL	1	0.900	-	-		OOG6_102470
Panther	1	1.100	-	-	LDO	PTHR45859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R372
SonicParanoid	1	1.000	-	-		X4090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750