Protein Alignment eIF2Bbeta and EIF2B4

DIOPT Version :9

• Sequence 1: NP_570020.1
• Gene: eIF2Bbeta / 31256
• FlyBaseID: FBgn0024996
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_001305894.1
• Gene: EIF2B4 / 8890
• HGNCID: 3260
• Length: 544
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 80/351 - (22%)
• Similarity: 148/351 - (42%)
• Gaps: 75/351 - (21%)

  Fly    10 TQLIHAIKV--------GLVEGSYNITNKTLDIFKYIIMSKSWQNADALMQIVRDQCKILQAALP 66
            :.:||...|        |||.||   ..:.:.:.:            ||.|:::|     ....|
Human   221 SSVIHPAMVRLGLQYSQGLVSGS---NARCIALLR------------ALQQVIQD-----YTTPP 265

  Fly    67 QETVTSNIARRILKLTREEFDLLHAKVQHFADDSQASLSLHKLVTQTSESNVSVDYSVPQH---- 127
            .|           :|:|:..:.|...:.........|.|:|..:...::...||..|..:.
Human   266 NE-----------ELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 319

  Fly   128 GLREALLDHLQEVETELETSSENICVQAEEHIHSSEIILTLGHSRSVENFLKRAIKKRQFLTIIV 192
            .||.|:..::||   ::..:::.|...|.:.|.:.::||..|.|..|...|:.|..:.:...::|
Human   320 ELRAAIDRYVQE---KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVV 381

  Fly   193 AECAPACRGHNLAASLANE-KNVEIVVIPDAAIFAMMSRVNKVIIGTHSVLANGGLRAACGAYTV 256
            .:..|...|.:...||.:. .....::||.|:.  ::..|:||::|.|::||||.:.:..|...:
Human   382 VDSRPWLEGRHTLRSLVHAGVPASYLLIPAASY--VLPEVSKVLLGAHALLANGSVMSRVGTAQL 444

  Fly   257 ALAAKHYSVPVIVLAPMYKLSPLHLCEQ---DAFNMVGCAEDVIPYDSIPAREA----------- 307
            ||.|:.::|||:|....||     .||:   |||    .:.::...|.:..:..
Human   445 ALVARAHNVPVLVCCETYK-----FCERVQTDAF----VSNELDDPDDLQCKRGEHVALANWQNH 500

  Fly   308 ---KVYSPMFDYVPPELVTLFISNTG 330
               ::.:.::|..|||||.|.|:..|
Human   501 ASLRLLNLVYDVTPPELVDLVITELG 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bbeta	NP_570020.1	GCD2	8..345	CDD:275543	80/351 (23%)
		IF-2B	21..334	CDD:279362	75/332 (23%)
EIF2B4	NP_001305894.1	GCD2	240..538	CDD:224105	75/332 (23%)
		IF-2B	240..530	CDD:279362	75/332 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810