Protein Alignment eIF2Bbeta and eif2b2

DIOPT Version :9

• Sequence 1: NP_570020.1
• Gene: eIF2Bbeta / 31256
• FlyBaseID: FBgn0024996
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_998068.1
• Gene: eif2b2 / 405839
• ZFINID: ZDB-GENE-040426-2605
• Length: 355
• Species: Danio rerio
• Alignment Length: 367
• Identity: 176/367 - (47%)
• Similarity: 242/367 - (65%)
• Gaps: 33/367 - (8%)

  Fly     2 KEQPLKE-ITQLIHAIK-----VGLVEGSYNITNKTLDIFKYIIMSKSWQNADALMQIVRDQCKI 60
            ||..|.| |...:..:|     .|.:.||.....:|..:.:.|.....|.:|..||:|:|.:.:.
Zfish     6 KETELSERIESFLSELKRCGSGSGSLRGSVETARETSSLLRRITAQARWSSAGELMEIIRKEGRR 70

  Fly    61 LQAALPQETVTSNIARRILKLTREEFDLLHAKVQHFADDSQASLSLHKLVTQ--TSESNVSVDYS 123
            :.||.|.||...|:.||:||:.|||:    |:.:..::::....|||||:|.  :||.|..
Zfish    71 MTAAQPSETTVGNMIRRVLKIIREEY----ARSRGSSEEADQQESLHKLLTSGGSSEDNFR---- 127

  Fly   124 VPQH--GLREALLDHLQEVETELETSSENICVQAEEHIHSSEIILTLGHSRSVENFLKRAIKKRQ 186
              ||  .|:..:::.:.|:.||||.:::||.:||.|||||:|:|:|:|.||:||.|||.|.:||:
Zfish   128 --QHFAHLKANVIEAINELLTELEGTTDNISMQALEHIHSNEVIMTIGRSRTVEAFLKDAARKRK 190

  Fly   187 FLTIIVAECAPACRGHNLAASLANEKNVEIVVIPDAAIFAMMSRVNKVIIGTHSVLANGGLRAAC 251
            | .:|||||||.|.||.:|.||:.| ::|..|||||||||:|||||||||||.:|||||||||..
Zfish   191 F-HVIVAECAPFCLGHEMATSLSKE-DIETTVIPDAAIFAVMSRVNKVIIGTQTVLANGGLRAVN 253

  Fly   252 GAYTVALAAKHYSVPVIVLAPMYKLSPLHLCEQDAFNMVGCAEDVIPYDSIPAREAKVYS----- 311
            |.:|:||||||:|.|:||.|||:||||....|.|.|:     :.|.|::.:|..|.::.|
Zfish   254 GTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEDDTFH-----KFVSPHEVLPFTEGEILSKVNAH 313

  Fly   312 -PMFDYVPPELVTLFISNTGGHAPSYVYRLLTELYHPEDLEI 352
             |:||||||||:||||||.|||||||:|||::|||||||.|:
Zfish   314 CPVFDYVPPELITLFISNIGGHAPSYIYRLMSELYHPEDHEL 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bbeta	NP_570020.1	GCD2	8..345	CDD:275543	166/352 (47%)
		IF-2B	21..334	CDD:279362	154/322 (48%)
eif2b2	NP_998068.1	IF-2B	37..337	CDD:279362	152/316 (48%)
		GCD2	38..348	CDD:224105	160/326 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581741
Domainoid	1	1.000	263	1.000	Domainoid score	I1891
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6507
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2739
OMA	1	1.010	-	-		QHG54382
OrthoDB	1	1.010	-	-		D396237at33208
OrthoFinder	1	1.000	-	-		FOG0005038
OrthoInspector	1	1.000	-	-		oto40916
orthoMCL	1	0.900	-	-		OOG6_102470
Panther	1	1.100	-	-	LDO	PTHR45859
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R372
SonicParanoid	1	1.000	-	-		X4090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800