Protein Alignment Lint-O and PHC2

DIOPT Version :10

• Sequence 1: NP_570018.1
• Gene: Lint-O / 31254
• FlyBaseID: FBgn0024993
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_001372041.1
• Gene: PHC2 / 1912
• HGNCID: 3183
• Length: 881
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 102/510 - (20%)
• Similarity: 167/510 - (32%)
• Gaps: 204/510 - (40%)

  Fly     6 DEDKEESPVQPTTHNSSAGSNGHDAKSPVVTTAPAATCSVSVSDASGAGASVRTTGRVKKPKQVY 70
            |:.||.:|.:.:...:.:|.:.|  :..:||..|             .|..|.|:..: :|...:
Human   493 DDWKEVAPGEKSVPETRSGPSPH--QQAIVTAMP-------------GGLPVPTSPNI-QPSPAH 541

  Fly    71 DPSDNYV---------SRASSNRNSLSSVPAT---SNVQSPP----------------------- 100
            :.....|         ...|.|.||.||:..|   :....||
Human   542 ETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAE 606

  Fly   101 ----------------------VKEATDSQDSTTSPVSEQQQQQLQQA----AQLRNFDTCQKCG 139
                                  :.|....||.||:..||.::..||::    |.|:.  .|:.||
Human   607 PFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEGAPLKL--KCELCG 669

  Fly   140 KSEPKRGSGHKSNFLTCKGCMQKWHFPCLPITFHNQSTARKKFKCDKCRYCRLCNVRGPGLSICS 204
            :                             :.|      ..|||..| |:|.:...:...:. |:
Human   670 R-----------------------------VDF------AYKFKRSK-RFCSMACAKRYNVG-CT 697

  Fly   205 LCVDAYHPDCNDPTLKQSKAVEANPNWRCFRCEACNIGGSTSASSEEQTG--------ARKSTAS 261
            ..|..:|.|.:    |..||..|..|.|  |....::...|..:.::.||        |.:.|.|
Human   698 KRVGLFHSDRS----KLQKAGAATHNRR--RASKASLPPLTKDTKKQPTGTVPLSVTAALQLTHS 756

  Fly   262 REDQA---------QPVVPRKSNAGRKKRVQSEPTGQEKAAKIEKLAKRRQPLKTEKKKEYKKEE 317
            :||.:         :|:.|..:::...:|.|    ||.
Human   757 QEDSSRCSDNSSYEEPLSPISASSSTSRRRQ----GQR--------------------------- 790

  Fly   318 DEEPAQIKVKVEKVEPVDMETEQIENNDLPGPEQESLSLRLTPITAVERRSHPVSTWSVEQVVQF 382
                             |:|...:...||.|.....|.            |.| :.|:||.|.:|
Human   791 -----------------DLELPDMHMRDLVGMGHHFLP------------SEP-TKWNVEDVYEF 825

  Fly   383 VAKRYP---KEANVFRYQDIDGASLLLLNRHDVMNGFGLKLGPALRVFELVMSLQ 434
            : :..|   :.|..||.|:|||.:||||....:|:...:||||||:::..:..|:
Human   826 I-RSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLK 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lint-O	NP_570018.1	PHD	134..187	CDD:214584	7/52 (13%)
		PHD	189..236	CDD:214584	11/46 (24%)
		SAM_Atherin-like	371..438	CDD:188982	25/67 (37%)
PHC2	NP_001372041.1	PHA03247	<116..571	CDD:223021	20/93 (22%)
		PHC2_SAM_assoc	693..812	CDD:465202	31/185 (17%)
		SAM_Ph1,2,3	812..880	CDD:188976	27/70 (39%)