Protein Alignment Spg7 and ftsH

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_417645.1
• Gene: ftsH / 947690
• ECOCYCID: EG11506
• Length: 644
• Species: Escherichia coli
• Alignment Length: 670
• Identity: 241/670 - (35%)
• Similarity: 375/670 - (55%)
• Gaps: 74/670 - (11%)

  Fly   170 VLWLFTIYMFVAFFSLLITPRSERP-EGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILH 233
            :|||....:.::.|      :|..| |.:.|.|.::.|:.      ||....:|.
E. coli     6 ILWLVIAVVLMSVF------QSFGPSESNGRKVDYSTFLQ------EVNNDQVRE---------- 48

  Fly   234 EGAVIKGRKVSSTIFHMAVADANKF-------EEKLRD--VEKRLGIKDGVPVTYDRQTDTTGRI 289
              |.|.||:::.|     ..|:|::       :.||.|  :.|.:.:....|    .:......|
E. coli    49 --ARINGREINVT-----KKDSNRYTTYIPVQDPKLLDNLLTKNVKVVGEPP----EEPSLLASI 102

  Fly   290 LM----LLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAK 350
            .:    :||:..:.:....:|:......:| ||.: .:|:....|...    ..|.||||..|||
E. coli   103 FISWFPMLLLIGVWIFFMRQMQGGGGKGAM-SFGK-SKARMLTEDQIK----TTFADVAGCDEAK 161

  Fly   351 QEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIG 415
            :||.|.|:||:.|.::|:||.|:|:|.|::||||.||||||||:|.||:|||.:::||:|:||..
E. coli   162 EEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFV 226

  Fly   416 GLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATK 480
            |:||:||||:|::.||.|||||:||||||:||||..  .:| |...|.||||||:||||||....
E. coli   227 GVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGA--GLG-GGHDEREQTLNQMLVEMDGFEGN 288

  Fly   481 EGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLAR 545
            ||::::|:|||.|:||.||||||||||.:::.||.:..|::|.:.|:..|.|  .|...:..:||
E. coli   289 EGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPL--APDIDAAIIAR 351

  Fly   546 LTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHES 610
            .||||||||:||:.|||||.|||..:..||....|.|.::::.|.|:||..::.|:::..||||:
E. coli   352 GTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEA 416

  Fly   611 GHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHL-YSKEELFDKMCMALGGRAAENLVF 674
            |||::|.::|..|.:.||||:|| ..|||...:.|....: .|:::|..::....|||.||.:::
E. coli   417 GHAIIGRLVPEHDPVHKVTIIPR-GRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY 480

  Fly   675 --NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGP-IYVRDADETEGGGAMGSGGKKPFSRAMES 736
              ..::|||.||::..|.:|.:.:.::|.::.||| :|..:..|...|.::...  |..|.....
E. coli   481 GPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKA--KHMSDETAR 543

  Fly   737 MIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESV 801
            :||.|.:.::...|.....:||.:.|.|..:.:||::.||:|..|:..|       :.:|.|...
E. coli   544 IIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDL-------MARRDVRPP 601

  Fly   802 E--FEQSLKNLSTDTDATKA 819
            .  .|....|.|.|..:.||
E. coli   602 AGWEEPGASNNSGDNGSPKA 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	230/627 (37%)
ftsH	NP_417645.1	hflB	1..644	CDD:182683	241/670 (36%)