DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and YME1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_015349.1	Gene:	YME1 / 856135	SGDID:	S000006228	Length:	747	Species:	Saccharomyces cerevisiae

Alignment Length:	734	Identity:	223/734 - (30%)
Similarity:	367/734 - (50%)	Gaps:	85/734 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TEKH--EQPEKGSAKAKDDSSK-EKKSAVAAEDGDK----SSRAAGEEAASTPTSSSTIGEPGED 150
            :||:  |.|.|   |..|.|.| ..||.:::.|..:    |:.....:.|:...|.:.:....::
Yeast    49 SEKNSGEMPPK---KEADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQE 110

  Fly   151 PNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLL--------ITPRSERPEGSTRYVSWNEFV 207
            .||:....|.:                  .||:.||        :..|.|.|..::.......::
Yeast   111 ANKDLTSPDAQ------------------AAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYM 157

  Fly   208 HHMLAVGEVKEL-IIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRL-- 269
            ..:..:|...|. .:|.::...:   ..|||......||       ::.:.:......:...|
Yeast   158 EALQRIGRHSEADAVRQNLLTAS---SAGAVNPSLASSS-------SNQSGYHGNFPSMYSPLYG 212

  Fly   270 GIKDGVPVTYDRQTDT-TGRILMLLLVCALL-MSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPF 332
            ..|:.:.|.....|.| ..|.:..|||..:| .|.:...|.|....::...:::......:..
Yeast   213 SRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTLLKSSEVADKSVDVAK-- 275

  Fly   333 DGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATE 397
               ..|.|.||.|..||:.|::|.||:||.|.||:.||.|:|:|.||.||||.||||||:|.|.|
Yeast   276 ---TNVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGE 337

  Fly   398 AQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGE 462
            |.|.|..|:||||.|:..|:||.|:||||.:.:.|||.||:|||:||||.:|:..:      ...
Yeast   338 AGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPKD------QAY 396

  Fly   463 SEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHL 527
            ::|||||||||:||.:...|::::.:||..:.|||||.||||||:.:.:|||.:..|.:|.:.|:
Yeast   397 AKQTLNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHM 461

  Fly   528 SSVKLES--PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGT 590
            ..:.|..  .||.    :||.|||.|||::||:.|:||::|.:...:.|...:.|:|.::::.|.
Yeast   462 KKITLADNVDPTI----IARGTPGLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGA 522

  Fly   591 EKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHL-YSKE 654
            |:::..|:.|.||..|:||:|||::......:..|.|.||:|| ..|||.....|....: .:|.
Yeast   523 ERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKATILPR-GRALGITFQLPEMDKVDITKR 586

  Fly   655 ELFDKMCMALGGRAAENLVFNR--ITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETE 717
            |...::.:.:||:.||.|::.:  .|:|..:||:..|..|.:.:.::||:|.:||:.:.:..|:
Yeast   587 ECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENWES- 650

  Fly   718 GGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQV 782
                        :|..:..:.|||...::..:.:....:||....:|.:||:.|:|.||||..::
Yeast   651 ------------WSNKIRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEI 703

  Fly   783 VQLIGPPPYDLGKRQVESV 801
            .|:......|..|....:|
Yeast   704 EQVCKGEKLDKLKTSTNTV 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	17/115 (15%)
		FtsH_fam	333..787	CDD:273520	174/458 (38%)
		AAA	378..513	CDD:278434	70/134 (52%)
		Peptidase_M41	595..785	CDD:279742	54/192 (28%)
YME1	NP_015349.1	HflB	227..712	CDD:223541	183/513 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810