DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and YTA12

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_013807.1	Gene:	YTA12 / 855114	SGDID:	S000004695	Length:	825	Species:	Saccharomyces cerevisiae

Alignment Length:	850	Identity:	306/850 - (36%)
Similarity:	455/850 - (53%)	Gaps:	104/850 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GLRHVR---------NALQ--RGGSQLIQLRSATGQPPRIGRELSL---LQLSRRQVMQ------ 48
            ||.|::         |.||  :.|::    .....:..::.:|:..   ::..|:||.:
Yeast    25 GLTHIKSLHTQYRLLNRLQENKSGNK----NEDNNEDAKLNKEIPTDEEVEAIRKQVEKYIEQTK 85

  Fly    49 ---LQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDS 110
               :.|.:|.....|..|::           |...:..|..:....:..|.::.|.|.:|||.:.
Yeast    86 NNTIPANWKEQKRKIDESIR-----------RLEDAVLKQESNRIQEERKEKEEENGPSKAKSNR 139

  Fly   111 SKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRSVLTKAVLWLFT 175
            :||:    ...:|:.|...  ......|.....:.:|....:||.|                ||.
Yeast   140 TKEQ----GYFEGNNSRNI--PPPPPPPPPKPPLNDPSNPVSKNVN----------------LFQ 182

  Fly   176 I---YMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAV 237
            |   :..::|...|:....|:.|     ::|.:|...:||.|.|.:||: .:..||.::|::...
Yeast   183 IGLTFFLLSFLLDLLNSLEEQSE-----ITWQDFREKLLAKGYVAKLIV-VNKSMVKVMLNDNGK 241

  Fly   238 IKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI-KD-GVPVTYDRQTDTTGRILMLLLVCALLM 300
            .:........::..:...:.||.||:..:..|.| || .:||.|.::.:....:..:|....::.
Yeast   242 NQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAMFQILPTVLMIA 306

  Fly   301 SI--ATRMKSIKSPLSMDSFNQMGRAKF----TLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDY 359
            .|  .||..:..:..|......:.|:|.    |..|.     .:.|:||||..|||:|:.|||.:
Yeast   307 GIIWLTRRSAQAAGGSRGGIFGLSRSKAKKFNTETDV-----KIKFKDVAGCDEAKEEIMEFVSF 366

  Fly   360 LKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRD 424
            ||.|.:|:::|||:||||:|.||||.||||||||.|.||.|||..::||||:||..|:|||||||
Yeast   367 LKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRD 431

  Fly   425 LFKEGKKRAPCIIYIDEIDAIGRQR-SGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLAS 488
            |||..::.||.|::||||||||:.| .|..|   |::.|.|.||||:||||||....:.|::||.
Yeast   432 LFKTARENAPSIVFIDEIDAIGKARQKGNFS---GANDERENTLNQMLVEMDGFTPADHVVVLAG 493

  Fly   489 TNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGA 553
            |||.|||||||||||||||||.||.|.|..||.||..||..:||.........|||.||||||||
Yeast   494 TNRPDILDKALLRPGRFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGA 558

  Fly   554 DIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWM 618
            |||||||||||.|||:.:..|...:.|.|:||::||.|::|..||..|:||:||||:|||:.||.
Yeast   559 DIANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWY 623

  Fly   619 LPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQN 683
            |..:|.||||:|:||...|||:|||.|.:..|.::::|.|:|.|:||||.:|.|.|..:|:||.:
Yeast   624 LKYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSVTSGASD 688

  Fly   684 DLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVAS 748
            |.:|||.:|.:.:.:.||:|.:|.:..:..|:        |...||||.....:||:|...:|..
Yeast   689 DFKKVTSMATAMVTELGMSDKIGWVNYQKRDD--------SDLTKPFSDETGDIIDSEVYRIVQE 745

  Fly   749 AYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYD---------LGKRQVESVEFE 804
            .:.....:|....:.:||:|:.||:||.|..:.::.|:|..|:.         |...:.|.:..|
Yeast   746 CHDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERNDAFDKYLNDYETEKIRKE 810

  Fly   805 QSLKN 809
            :. ||
Yeast   811 EE-KN 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	26/109 (24%)
		FtsH_fam	333..787	CDD:273520	229/454 (50%)
		AAA	378..513	CDD:278434	87/135 (64%)
		Peptidase_M41	595..785	CDD:279742	73/189 (39%)
YTA12	NP_013807.1	FtsH_ext	<205..282	CDD:377663	20/82 (24%)
YTA12	NP_013807.1	FtsH_fam	290..784	CDD:273520	238/509 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910