Protein Alignment Spg7 and RPT4

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_014902.3
• Gene: RPT4 / 854433
• SGDID: S000005785
• Length: 437
• Species: Saccharomyces cerevisiae
• Alignment Length: 489
• Identity: 144/489 - (29%)
• Similarity: 227/489 - (46%)
• Gaps: 90/489 - (18%)

  Fly   120 AEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFS 184
            :|:.|......||.:....|..|...:| |.|.:....::|:
Yeast     2 SEEQDPLLAGLGETSGDNHTQQSHEQQP-EQPQETEEHHEEE----------------------- 42

  Fly   185 LLITPRSERPEGSTRYVSWNEFVHHMLA--------------VGEVKELIIRPD-----MEMVTI 230
                |....||......:.|:|...:|.              :.::::|..:.:     ::.:..
Yeast    43 ----PSRVDPEQEAHNKALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKALQSIGQ 103

  Fly   231 ILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIKDGVPVTYDRQTDTTGRILMLLLV 295
            ::  |.|:|  ::|...:.:..:...::...:|:...|..:|.||.||.|..|.|..|||
Yeast   104 LI--GEVMK--ELSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRIL----- 159

  Fly   296 CALLMSIATRMKSIKSPL--SMDSFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVD 358
                       .....||  :|.||.|   .:.|    |||        :.||:|..:|::|.::
Yeast   160 -----------PRETDPLVYNMTSFEQ---GEIT----FDG--------IGGLTEQIRELREVIE 198

  Fly   359 Y-LKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARV 422
            . ||:||.:||:|.|.|:|.||.||||.||||||||||......|:....|..::...|..|..:
Yeast   199 LPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASGIVDKYIGESARII 263

  Fly   423 RDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLA 487
            |::|...|:..||||::||:||||.:|.   |.|..:..|.::||.:||.:|||........::.
Yeast   264 REMFAYAKEHEPCIIFMDEVDAIGGRRF---SEGTSADREIQRTLMELLTQMDGFDNLGQTKIIM 325

  Fly   488 STNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSG 552
            :|||.|.||.|||||||.||.:.|.||..|.|.|||:.|.:.|| ::....| :...:::.||:|
Yeast   326 ATNRPDTLDPALLRPGRLDRKVEIPLPNEAGRLEIFKIHTAKVK-KTGEFDF-EAAVKMSDGFNG 388

  Fly   553 ADIANVCNEAALHAARNTQMEVSSKNLEYAVERL 586
            |||.|...||...|.|:.:..::..:|..||.::
Yeast   389 ADIRNCATEAGFFAIRDDRDHINPDDLMKAVRKV 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	134/431 (31%)
RPT4	NP_014902.3	PRK03992	66..433	CDD:179699	128/397 (32%)