DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and ftsh10

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_172231.2	Gene:	ftsh10 / 837265	AraportID:	AT1G07510	Length:	813	Species:	Arabidopsis thaliana

Alignment Length:	805	Identity:	330/805 - (40%)
Similarity:	461/805 - (57%)	Gaps:	105/805 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 AEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKK 115
            |.:.|..||.|..|.......||....| |.|.|.      |..::..| |.|.||..:..|.:
plant    60 ASFAARKGLEAGDLSRAFANPRLRRFFS-SQTPKK------KNYENYYP-KDSKKAPKNEQKSE- 115

  Fly   116 SAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNEN-DEKMRSVLTKAVLWLFTIYMF 179
                :.||.|                           ||.||| .:...:.....::.|..|.:.
plant   116 ----SRDGSK---------------------------KNENENAGDAFSNEYQNMLIPLMAIALI 149

  Fly   180 VAFFSLLITPRSERPEGS--TRYVSWNEFVHHMLAVG----------EVKELIIR--PDMEMVTI 230
            ::.|||          ||  .:.:|:.||.:.:|..|          ||.::.:|  |..:....
plant   150 LSTFSL----------GSREQQQISFQEFKNKLLEAGLVDHIDVSNKEVAKVYVRSSPKSQTTEE 204

  Fly   231 ILH---EGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIK--DGVPVTYDRQTDTTGRIL 290
            ::.   .|...|||. ....::..:.....|||||.:.::.:|:.  |.|||||..:|.....:|
plant   205 VVQGPGNGVPAKGRG-GQYKYYFNIGSVESFEEKLEEAQEAIGVNSHDFVPVTYVSETIWYQELL 268

  Fly   291 ----MLLLVCALLMSIATRMK----SIKSP---LSMDSFNQMGRAKFTLVDPFDGGRGVLFRDVA 344
                .||||..|:.. |.||:    .:..|   .....|| :|:|:.|..|. :....:.|:|||
plant   269 RFAPTLLLVATLIFG-ARRMQGGLGGLGGPGGKAGRGIFN-IGKAQITRADK-NSKNKIYFKDVA 330

  Fly   345 GLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSE 409
            |..|||||:.|||.:|::|:||:.||||:|:||||:||||.||||||||.|.|:.|||||::||:
plant   331 GCEEAKQEIMEFVHFLQNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESAVPFLSISGSD 395

  Fly   410 FIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRS-GTESMGQGSSGESEQTLNQLLVE 473
            |:||..|:|.:|||:||:|.::.||.||:|||||||||.|. |..|   |.:.|.|.||||||||
plant   396 FMEMFVGVGPSRVRNLFQEARQCAPSIIFIDEIDAIGRARGRGGFS---GGNDERESTLNQLLVE 457

  Fly   474 MDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTT 538
            |||..|..||::||.|||.|||||||||||||||.|.||.|.:..|.:||:.:|..:||:..|:.
plant   458 MDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFQIYLKKIKLDHEPSY 522

  Fly   539 FSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERK 603
            :|||||.|||||:|||||||||||||.|||:....|:..:.:.|::|::||.||::..:|..||:
plant   523 YSQRLAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFDSAIDRVIGGLEKKNRVISKLERR 587

  Fly   604 VIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRA 668
            .:||||||||:.||.|.:::.|||||||||.:.|||||||.|:|..|.:||:|||..||.|||||
plant   588 TVAYHESGHAVAGWFLEHAEPLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRA 652

  Fly   669 AENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPI-YVRDADETEGGGAMGSGGKKPFSR 732
            ||.::..||:||||||||||||:.|:|:..:|.:|.:|.: :.:..||.          .||:|.
plant   653 AEQVLIGRISTGAQNDLEKVTKMTYAQVAVYGFSDKIGLLSFPQREDEF----------SKPYSN 707

  Fly   733 AMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKR- 796
            ...:|||.|.|..|..||:.|..::..|::::.::||.|||||.|..|.:.:::|..|:..|:.
plant   708 RTGAMIDEEVREWVGKAYKRTVELIEEHKEQVAQIAELLLEKEVLHQDDLTKVLGERPFKSGETT 772

  Fly   797 ---QVESVEFEQSLKNLSTDTDATK 818
               :.:| .||:|.|....::...|
plant   773 NYDRFKS-GFEESEKESQKESVPVK 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	27/123 (22%)
		FtsH_fam	333..787	CDD:273520	245/455 (54%)
		AAA	378..513	CDD:278434	89/135 (66%)
		Peptidase_M41	595..785	CDD:279742	90/190 (47%)
ftsh10	NP_172231.2	FtsH_ext	139..254	CDD:284011	27/125 (22%)
		FtsH_fam	263..762	CDD:273520	261/514 (51%)
		P-loop_NTPase	311..>414	CDD:304359	60/103 (58%)
		AAA	364..496	CDD:278434	88/134 (66%)
		Peptidase_M41	579..760	CDD:279742	90/190 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920