DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and FTSH11

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_568787.1	Gene:	FTSH11 / 835398	AraportID:	AT5G53170	Length:	806	Species:	Arabidopsis thaliana

Alignment Length:	787	Identity:	251/787 - (31%)
Similarity:	381/787 - (48%)	Gaps:	144/787 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 AKDDSSKEKKSAVAAEDGDKSSRAAGE-EAASTPTSSSTI--------GEPGEDPN-----KNSN 156
            |.|.....|.||....|..:|:|...: |.:...|:...:        ||..|..|     |..:
plant    68 ASDSDFIPKDSAFEVTDSAESNRLVSDTEVSELETNDRFVGGEETKSGGEEAEVSNGVTEGKEED 132

  Fly   157 ENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELII 221
            :...|.|.|:....||             ....|:........::||..|...   ...:::||.
plant   133 QKKSKFRIVVLMMALW-------------AAIKRAIEKVMEWEWLSWWPFSRQ---EKRLEKLIA 181

  Fly   222 RPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKR------------LGIKDG 274
            ..|..      .:.|.::|..::....|:..|...:||::...|:.|            ..|.:.
plant   182 EADAN------PKDAALQGALLAELNKHIPEAVVQRFEQREHTVDSRGVAEYIRALVITNAISEY 240

  Fly   275 VPVTYDRQTDTTGRILMLL--------------------------------------------LV 295
            :|   |.||.....:..||                                            ||
plant   241 LP---DEQTGKPSSLPALLQELKHRASGNMDESFVNPGISEKQPLHVTMVNPKVSNKSRFAQELV 302

  Fly   296 CALLMSIATRMKSIKSPLSMDSF-------NQMGRAKFTLVDPFDGGRGV-------LFRDVAGL 346
            ..:|.::|..:..|....::..:       ...|....:...|.:..:.:       .|:||.|.
plant   303 STILFTVAVGLVWIMGAAALQKYIGSLGGIGTSGVGSSSSYSPKELNKEITPEKNVKTFKDVKGC 367

  Fly   347 SEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFI 411
            .:||||::|.|:|||:|.|:.|||.|:|:|.||.|.||.||||||||:|.||.|||....||||.
plant   368 DDAKQELEEVVEYLKNPSKFTRLGGKLPKGILLTGAPGTGKTLLAKAIAGEAGVPFFYRAGSEFE 432

  Fly   412 EMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDG 476
            ||..|:||.|||.||:..||:|||||:||||||:|..|...|       |.:::||:||||||||
plant   433 EMFVGVGARRVRSLFQAAKKKAPCIIFIDEIDAVGSTRKQWE-------GHTKKTLHQLLVEMDG 490

  Fly   477 MATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQ 541
            ....||::::|:||..||||.||.|||||||||::..|.:..|:||.|.:|....:......  :
plant   491 FEQNEGIIVMAATNLPDILDPALTRPGRFDRHIVVPSPDVRGREEILELYLQGKPMSEDVDV--K 553

  Fly   542 RLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIA 606
            .:||.||||:|||:||:.|.||:.||.....::||:.||:|.:|:|.|||:::..:|...:|:.|
plant   554 AIARGTPGFNGADLANLVNIAAIKAAVEGAEKLSSEQLEFAKDRIVMGTERKTMFVSEDSKKLTA 618

  Fly   607 YHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPS-EQHLYSKEELFDKMCMALGGRAAE 670
            |||||||:|......:..:.|.||:||.| |||.....|| ::...||.:|..::.:.:|||.||
plant   619 YHESGHAIVALNTKGAHPIHKATIMPRGS-ALGMVTQLPSNDETSVSKRQLLARLDVCMGGRVAE 682

  Fly   671 NLVF--NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRA 733
            .|:|  :.|||||.:||.:.|::|...:...||::.:||:::::...::
plant   683 ELIFGLDHITTGASSDLSQATELAQYMVSSCGMSEAIGPVHIKERPSSD---------------- 731

  Fly   734 MESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQV 798
            |:|.||.|...::..||:..:.:|..|..:|..||.||||.|||..:.:.:::.|      |::.
plant   732 MQSRIDAEVVKLLREAYERVKSLLKRHEKQLHTLANALLEYETLTAEDIKRILLP------KQEG 790

  Fly   799 ESVEFEQ 805
            |..|.:|
plant   791 EKFEEQQ 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	18/116 (16%)
		FtsH_fam	333..787	CDD:273520	197/463 (43%)
		AAA	378..513	CDD:278434	80/134 (60%)
		Peptidase_M41	595..785	CDD:279742	64/192 (33%)
FTSH11	NP_568787.1	FtsH_fam	355..784	CDD:273520	197/454 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820