DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and FTSH6

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_568311.2	Gene:	FTSH6 / 831377	AraportID:	AT5G15250	Length:	688	Species:	Arabidopsis thaliana

Alignment Length:	718	Identity:	255/718 - (35%)
Similarity:	401/718 - (55%)	Gaps:	74/718 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SSRAAGEEAASTPTSSSTIGEPGEDP---NKNSNENDEKMRSVL-----TKA-VLWLFTIYMFV- 180
            ||.|.....::.||.|.. .:..:.|   :|:|:.:...:::.:     ||. :|.|.|...|.
plant     6 SSSALSFPLSNIPTCSKK-SQQFQKPASLSKSSHTHKPSLKTQILHHKFTKRNLLSLTTALGFTS 69

  Fly   181 AFFSLLITPRSERP----EGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGR 241
            |..::|..|....|    |.::..:|::.|:.| |...|||::.:..:..:..:.:....|.|.:
plant    70 ALGTVLAHPAKAEPEAPIEATSNRMSYSRFLQH-LKENEVKKVDLIENGTVAIVEISNPVVGKIQ 133

  Fly   242 KVSSTIFHMAVADANKFEEKLRDVEKRLGIKDGVPVTYDRQTDTTGRILM---------LLLVCA 297
            :|...:..:.|....:.:||..|....       |:..:     .|..|:         |:|:.:
plant   134 RVRVNLPGLPVDLVREMKEKNVDFAAH-------PMNVN-----WGAFLLNFLGNLGFPLILLVS 186

  Fly   298 LLMSIATRMKSIKSPLSMDSFNQMGR--AKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYL 360
            ||::.::|    ::|...:....:||  |||.:    :...|:.|.||||:.||||:.:|.|::|
plant   187 LLLTSSSR----RNPAGPNLPFGLGRSKAKFQM----EPNTGITFEDVAGVDEAKQDFEEIVEFL 243

  Fly   361 KSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDL 425
            |:|||:..||||:|:|.||.||||.||||||||:|.||.|||.|::|||||||..|:||:|.|||
plant   244 KTPEKFSALGAKIPKGVLLTGPPGTGKTLLAKAIAGEAGVPFFSLSGSEFIEMFVGVGASRARDL 308

  Fly   426 FKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTN 490
            |.:.|..:|||::||||||:||.| || .:| |.:.|.||||||:|.||||.|...||:::|:||
plant   309 FNKAKANSPCIVFIDEIDAVGRMR-GT-GIG-GGNDEREQTLNQILTEMDGFAGNTGVIVIAATN 370

  Fly   491 RADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADI 555
            |.:|||.||||||||||.:.:.||.:..|:||.:.|..|.||:...:.  ..:|..||||||||:
plant   371 RPEILDSALLRPGRFDRQVSVGLPDIRGREEILKVHSRSKKLDKDVSL--SVIAMRTPGFSGADL 433

  Fly   556 ANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLP 620
            ||:.||||:.|.|..:.:::...::.:::|:|.|.| .:..:....:.::||||.|||:...:..
plant   434 ANLMNEAAILAGRRGKDKITLTEIDDSIDRIVAGME-GTKMIDGKSKAIVAYHEVGHAICATLTE 497

  Fly   621 NSDILLKVTIVPRTSLALGFAQYTPSEQ-HLYSKEELFDKMCMALGGRAAENLVFN--RITTGAQ 682
            ..|.:.|||:||| ..|.|...:.|.|. .|.||::||.::...|||||||:::|.  .|||||.
plant   498 GHDPVQKVTLVPR-GQARGLTWFLPGEDPTLVSKQQLFARIVGGLGGRAAEDVIFGEPEITTGAA 561

  Fly   683 NDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVA 747
            .||::||:||...:..|||:: :||..:.|....:....:....:...|..:...||:..:.::.
plant   562 GDLQQVTEIARQMVTMFGMSE-IGPWALTDPAVKQNDVVLRMLARNSMSEKLAEDIDSCVKKIIG 625

  Fly   748 SAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVEFEQSLKNLST 812
            .||:..:..:..:|:.::||.:.|||||||..|:...::.                |.:.:.|:|
plant   626 DAYEVAKKHVRNNREAIDKLVDVLLEKETLTGDEFRAILS----------------EYTDQPLNT 674

  Fly   813 DTD 815
            |.|
plant   675 DGD 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	23/109 (21%)
		FtsH_fam	333..787	CDD:273520	202/456 (44%)
		AAA	378..513	CDD:278434	85/134 (63%)
		Peptidase_M41	595..785	CDD:279742	64/192 (33%)
FTSH6	NP_568311.2	FtsH_ext	<88..161	CDD:284011	15/80 (19%)
		ftsH	91..671	CDD:214386	231/624 (37%)
		AAA	260..393	CDD:278434	85/135 (63%)
		Peptidase_M41	472..663	CDD:279742	64/192 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	61	1.000	Domainoid score	I3815
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820