DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and VAR2

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001323509.1	Gene:	VAR2 / 817646	AraportID:	AT2G30950	Length:	699	Species:	Arabidopsis thaliana

Alignment Length:	520	Identity:	221/520 - (42%)
Similarity:	324/520 - (62%)	Gaps:	49/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 SPLSMDSFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPR 375
            :||   .|.| .:|||.:    :...||.|.||||:.||||:..|.|::||.||::..:|||:|:
plant   209 NPL---QFGQ-SKAKFQM----EPNTGVTFDDVAGVDEAKQDFMEVVEFLKKPERFTAVGAKIPK 265

  Fly   376 GALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYID 440
            |.||:||||.||||||||:|.||.|||.|::||||:||..|:||:|||||||:.|:.||||:::|
plant   266 GVLLIGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKENAPCIVFVD 330

  Fly   441 EIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRF 505
            ||||:|||| || .:| |.:.|.||||||||.||||.....||:::|:||||||||.||||||||
plant   331 EIDAVGRQR-GT-GIG-GGNDEREQTLNQLLTEMDGFEGNTGVIVVAATNRADILDSALLRPGRF 392

  Fly   506 DRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNT 570
            ||.:.:|:|.:..|.:|.:.|..:.|.::..:.  :.:|..||||||||:||:.||||:.|.|..
plant   393 DRQVSVDVPDVKGRTDILKVHAGNKKFDNDVSL--EIIAMRTPGFSGADLANLLNEAAILAGRRA 455

  Fly   571 QMEVSSKNLEYAVERLVGG------TEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVT 629
            :..:|||.::.:::|:|.|      |:.:|.:|       :||||.|||:.|.:.|..|.:.|||
plant   456 RTSISSKEIDDSIDRIVAGMEGTVMTDGKSKSL-------VAYHEVGHAVCGTLTPGHDAVQKVT 513

  Fly   630 IVPRTSLALGFAQYTPSEQ-HLYSKEELFDKMCMALGGRAAENLVF--NRITTGAQNDLEKVTKI 691
            ::|| ..|.|...:.||:. .|.||::||.::...|||||||.::|  :.:||||..||:::|.:
plant   514 LIPR-GQARGLTWFIPSDDPTLISKQQLFARIVGGLGGRAAEEIIFGDSEVTTGAVGDLQQITGL 577

  Fly   692 AYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGI 756
            |...:..|||:| :||..:.|: ..:....|....:...|..:...||:..:.:..|||:.....
plant   578 ARQMVTTFGMSD-IGPWSLMDS-SAQSDVIMRMMARNSMSEKLAEDIDSAVKKLSDSAYEIALSH 640

  Fly   757 LTTHRDKLEKLAEALLEKETLDYDQVVQLIGP----PPYDLGKRQVESVEFEQSLKNLSTDTDAT 817
            :..:|:.::||.|.||||||:..|:...::..    ||             |..:.:.:|.|.|:
plant   641 IKNNREAMDKLVEVLLEKETIGGDEFRAILSEFTEIPP-------------ENRVPSSTTTTPAS 692

Fly 818 817
plant 693 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011
		FtsH_fam	333..787	CDD:273520	208/462 (45%)
		AAA	378..513	CDD:278434	89/134 (66%)
		Peptidase_M41	595..785	CDD:279742	66/192 (34%)
VAR2	NP_001323509.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820