DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and ftsh3

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_850129.1	Gene:	ftsh3 / 817456	AraportID:	AT2G29080	Length:	809	Species:	Arabidopsis thaliana

Alignment Length:	844	Identity:	327/844 - (38%)
Similarity:	466/844 - (55%)	Gaps:	110/844 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GLRHVRNALQRGGSQLIQLRSATGQPPRIGRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTP 68
            |:|.....|...|.:...:....|....|.|..:.| .||:.::.     ..::|:.|     .|
plant    24 GVRSAARLLTSPGLEAASVNEVEGGLGFIRRHFASL-ASRKGLVN-----NDLIGVFA-----NP 77

  Fly    69 KEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEE 133
            :      ||...|...|         |.:..|....|.|.:...::||
plant    78 R------LRRFFSDEAP---------KKKNYENYFPKDKQEPKSDQKS----------------- 110

  Fly   134 AASTPTSSSTIGEPGEDPNKNSNEN-DEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGS 197
                        |..|...||.||| .:...:.....::.|..:.:|.:.||.        ..|.
plant   111 ------------EHKEGSEKNENENVGDMFMNRFQNLLIPLLALAVFFSTFSF--------GSGE 155

  Fly   198 TRYVSWNEFVHHMLAVG----------EVKELIIR--PDMEMVTIILH-EGAVIKGRKVSSTI-F 248
            .:.:|:.||.:.:|..|          .|.::.:|  |..:..|.::| .|..|..::..... :
plant   156 QQQISFQEFKNKLLEPGLVDHIDVSNKSVAKVYVRSTPKDQQTTDVVHGNGNGIPAKRTGGQYKY 220

  Fly   249 HMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQT---DTTGRILMLLLVCALLMSIATRMKS 308
            :..:...:.|||||.:.::.||:  .:.|||||..:.   ....|....||:...|:..|.||
plant   221 YFNIGSVDSFEEKLEEAQEALGVDRHEYVPVTYVSEMVWYQEFMRFAPTLLLLGTLIYGARRM-- 283

  Fly   309 IKSPLSMDS---------FNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPE 364
             :..|.:..         || :|:|..|..|.....: :.|:||||..|||||:.|||.:||:|:
plant   284 -QGGLGVGGTGGKNGRGIFN-IGKATITRADKHSKNK-IYFKDVAGCDEAKQEIMEFVHFLKNPK 345

  Fly   365 KYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEG 429
            ||:.||||:|:||||:||||.||||||||.|.|:.|||||::||:|:||..|:|.:|||.||:|.
plant   346 KYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEA 410

  Fly   430 KKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADI 494
            ::.||.||:|||||||||.|.   ..|.|.:.|.|.|||||||||||..|..||::||.|||.||
plant   411 RQAAPSIIFIDEIDAIGRARG---RGGLGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDI 472

  Fly   495 LDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVC 559
            |||||||||||||.|.||.|.:..|.:||:.:|..:||:..|:.:|||||.|||||:||||||||
plant   473 LDKALLRPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEPSYYSQRLAALTPGFAGADIANVC 537

  Fly   560 NEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDI 624
            |||||.|||:....|:..:.|.|::|::||.||::..:|..||:.:||||||||:|||.|.:::.
plant   538 NEAALIAARHEGATVTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVGWFLEHAEP 602

  Fly   625 LLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVT 689
            |||||||||.:.|||||||.|:|..|.:||:|||..||.|||||||.::..:|:|||||||||||
plant   603 LLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGKISTGAQNDLEKVT 667

  Fly   690 KIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTE 754
            |:.|:|:..:|.:|.:|.:.....|:       |....||:|....::||.|.|..||.||:.|.
plant   668 KMTYAQVAVYGFSDKVGLLSFPPRDD-------GYDFSKPYSNKTGAIIDEEVRDWVAKAYERTV 725

  Fly   755 GILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVE-FEQSLKNLSTDTDAT 817
            .::..|:.|:.::||.|||||.|..|.:::::|..|:.  ..:|.:.: |:...:....|:.||
plant   726 ELVEEHKVKVAEIAELLLEKEVLHQDDLLKILGERPFK--SAEVTNYDRFKSGFEETEKDSAAT 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	24/120 (20%)
		FtsH_fam	333..787	CDD:273520	247/453 (55%)
		AAA	378..513	CDD:278434	88/134 (66%)
		Peptidase_M41	595..785	CDD:279742	91/189 (48%)
ftsh3	NP_850129.1	FtsH_ext	135..244	CDD:377663	24/116 (21%)
ftsh3	NP_850129.1	FtsH_fam	259..758	CDD:273520	261/513 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920