DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and spg7

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_001923118.1	Gene:	spg7 / 794740	ZFINID:	ZDB-GENE-030131-5391	Length:	788	Species:	Danio rerio

Alignment Length:	793	Identity:	376/793 - (47%)
Similarity:	507/793 - (63%)	Gaps:	96/793 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PRIGRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTE 94
            |.|.|.:.|....|..::..||:...::|              ..|..|.|:            .
Zfish    61 PLIPRLIGLEFHCRHNLLTTQAKLWKLLG--------------STHYFSTSN------------R 99

  Fly    95 KHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNEND 159
            |||..:.|..|..::..:|||   ..|..|:..|
Zfish   100 KHENKQGGKGKTPEEEEEEKK---RREQEDQMYR------------------------------- 130

  Fly   160 EKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPD 224
            |::|           |:::.....|||   .|....|..  :|||:||:.|||.|||..:.:.|:
Zfish   131 ERLR-----------TLFIIAVIMSLL---NSINTSGGN--ISWNDFVNEMLAKGEVSRVQVVPE 179

  Fly   225 MEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTTG 287
            .::|.|.||.||||.||...:.::.|.||:.:|||||||..|:.|.|  ||.:||||.| |...|
Zfish   180 SDIVEIYLHPGAVIFGRPRLALMYRMQVANIDKFEEKLRAAEEELNIDAKDRIPVTYKR-TGFFG 243

  Fly   288 RILMLLLVCALLMSIATRMKSIKSPLSMD----SFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSE 348
            ..|..|.:.|:.::|...:..:......|    :|||:..||||:||. ..|:||.|:||||:.|
Zfish   244 NALYALGMAAIGVAILWYIFRLAGMGGRDGGFSAFNQLKMAKFTIVDG-KSGKGVSFKDVAGMRE 307

  Fly   349 AKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEM 413
            ||.||||||||||:|::|.:||||||:|:||||||||||||||||||||||||||:|.||||:|:
Zfish   308 AKMEVKEFVDYLKNPDRYLQLGAKVPKGSLLLGPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEV 372

  Fly   414 IGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMA 478
            ||||||||||.||||.:.|||||:|||||||:|::||  .:|...|:.|.||||||||||||||.
Zfish   373 IGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRS--TNMSGFSNTEEEQTLNQLLVEMDGMG 435

  Fly   479 TKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRL 543
            |.:.|::|||||||||||.||:||||.||||.||||||.|||||||:||..:||..|...:|.||
Zfish   436 TTDHVIVLASTNRADILDNALMRPGRLDRHIFIDLPTLQERKEIFEQHLKILKLTQPADFYSLRL 500

  Fly   544 ARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYH 608
            |.||||||||||||:||||||||||.....:.:.:.||||||::.|:.|:|..||..|::|:|:|
Zfish   501 AELTPGFSGADIANICNEAALHAAREGFKSIDTFSFEYAVERVIAGSVKKSKILSKEEQRVVAFH 565

  Fly   609 ESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLV 673
            |||||||||:|.:::.::||:|.|||:.||||||..|.:|.|::||:||::|||||||||:|.:.
Zfish   566 ESGHALVGWLLEHTEAVMKVSIAPRTNAALGFAQILPRDQFLFTKEQLFERMCMALGGRASEAIT 630

  Fly   674 FNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMI 738
            ||::|||||:||.|||::|||.:|::||.|::|.:...|::...|      .|::|||:.::..:
Zfish   631 FNKVTTGAQDDLRKVTRVAYSMVKQYGMVDSVGQVSFPDSENQSG------IGRRPFSQGLQQQM 689

  Fly   739 DNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVES--- 800
            |.||:.::|.||:.||.:|..:||||..||.||||:|.::|:.:..|:||||:. .||.:..
Zfish   690 DLEAKMLIAKAYRHTEKLLLDNRDKLILLANALLEREVVNYNDIEALLGPPPFG-PKRMIAPQSW 753

  Fly   801 VEFEQSLKNLSTD 813
            ||.|:.|::...|
Zfish   754 VEAERDLQDTGED 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	43/106 (41%)
		FtsH_fam	333..787	CDD:273520	277/453 (61%)
		AAA	378..513	CDD:278434	102/134 (76%)
		Peptidase_M41	595..785	CDD:279742	92/189 (49%)
spg7	XP_001923118.1	FtsH_ext	136..233	CDD:284011	42/101 (42%)
		FtsH_fam	257..738	CDD:273520	288/489 (59%)
		AAA	337..470	CDD:278434	102/134 (76%)
		Peptidase_M41	552..736	CDD:279742	92/189 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587189
Domainoid	1	1.000	204	1.000	Domainoid score	I2903
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31133
Inparanoid	1	1.050	661	1.000	Inparanoid score	I741
OMA	1	1.010	-	-		QHG48979
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0005483
OrthoInspector	1	1.000	-	-		otm25610
orthoMCL	1	0.900	-	-		OOG6_106460
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3185
SonicParanoid	1	1.000	-	-		X4433
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800