Protein Alignment Spg7 and SPG7

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001350779.1
• Gene: SPG7 / 6687
• HGNCID: 11237
• Length: 809
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 374/747 - (50%)
• Similarity: 492/747 - (65%)
• Gaps: 81/747 - (10%)

  Fly    33 GRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHE 97
            ||.|..|||     ..|...::.|.||:.:. .|....|||..|  |..|....|:...:..|.:
Human    57 GRALQSLQL-----RLLTPTFEGINGLLLKQ-HLVQNPVRLWQL--LGGTFYFNTSRLKQKNKEK 113

  Fly    98 QPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKM 162
            ...||.|..:|:..:.::     |..|:..|                               |::
Human   114 DKSKGKAPEEDEEERRRR-----ERDDQMYR-------------------------------ERL 142

  Fly   163 RSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEM 227
            |::|..||:        ::..:.|.|        |...:|||:|||.|||.|||:.:.:.|:.::
Human   143 RTLLVIAVV--------MSLLNALST--------SGGSISWNDFVHEMLAKGEVQRVQVVPESDV 191

  Fly   228 VTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTTGRIL 290
            |.:.||.|||:.||...:.::.|.||:.:|||||||..|..|.|  ||.:||:|.| |...|..|
Human   192 VEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKR-TGFFGNAL 255

  Fly   291 MLLLVCALLMSIATRMKSIKSPLSMD----SFNQMGRAKFTLVDPFDG--GRGVLFRDVAGLSEA 349
            ..:.:.|:.::|...:..:......:    :|||:..|:||:|   ||  |:||.|:||||:.||
Human   256 YSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIV---DGKMGKGVSFKDVAGMHEA 317

  Fly   350 KQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMI 414
            |.||:||||||||||::.:||||||:||||||||||||||||||||||||||||:|.|.||:|:|
Human   318 KLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVI 382

  Fly   415 GGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMAT 479
            |||||||||.||||.:.|||||:|||||||:|::||.|  |...|:.|.||||||||||||||.|
Human   383 GGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT--MSGFSNTEEEQTLNQLLVEMDGMGT 445

  Fly   480 KEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLA 544
            .:.|::|||||||||||.||:||||.|||:.||||||.||:||||:||.|:||....|.:|||||
Human   446 TDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLA 510

  Fly   545 RLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHE 609
            .||||||||||||:||||||||||.....|.:.|.||||||::.||.|:|..||..|:||:|:||
Human   511 ELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHE 575

  Fly   610 SGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVF 674
            ||||||||||.:::.::||:|.|||:.||||||..|.:|||::||:||::|||||||||:|.|.|
Human   576 SGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSF 640

  Fly   675 NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMID 739
            |.:|:|||:||.|||:||||.:|:|||...:|||...:|.|    |.||. |::|||:.::.|:|
Human   641 NEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQE----GLMGI-GRRPFSQGLQQMMD 700

  Fly   740 NEARHVVASAYQTTEGILTTHRDKLEKLAEAL 771
            :|||.:||.||:.||.:|..:.|||:  |.||
Human   701 HEARLLVAKAYRHTEKVLQDNLDKLQ--ARAL 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	343/602 (57%)
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..133		5/29 (17%)
		HflB	147..730	CDD:440233	343/611 (56%)