DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and SPG7

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001350779.1	Gene:	SPG7 / 6687	HGNCID:	11237	Length:	809	Species:	Homo sapiens

Alignment Length:	747	Identity:	374/747 - (50%)
Similarity:	492/747 - (65%)	Gaps:	81/747 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHE 97
            ||.|..|||     ..|...::.|.||:.:. .|....|||..|  |..|....|:...:..|.:
Human    57 GRALQSLQL-----RLLTPTFEGINGLLLKQ-HLVQNPVRLWQL--LGGTFYFNTSRLKQKNKEK 113

  Fly    98 QPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKM 162
            ...||.|..:|:..:.::     |..|:..|                               |::
Human   114 DKSKGKAPEEDEEERRRR-----ERDDQMYR-------------------------------ERL 142

  Fly   163 RSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEM 227
            |::|..||:        ::..:.|.|        |...:|||:|||.|||.|||:.:.:.|:.::
Human   143 RTLLVIAVV--------MSLLNALST--------SGGSISWNDFVHEMLAKGEVQRVQVVPESDV 191

  Fly   228 VTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTTGRIL 290
            |.:.||.|||:.||...:.::.|.||:.:|||||||..|..|.|  ||.:||:|.| |...|..|
Human   192 VEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKR-TGFFGNAL 255

  Fly   291 MLLLVCALLMSIATRMKSIKSPLSMD----SFNQMGRAKFTLVDPFDG--GRGVLFRDVAGLSEA 349
            ..:.:.|:.::|...:..:......:    :|||:..|:||:|   ||  |:||.|:||||:.||
Human   256 YSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIV---DGKMGKGVSFKDVAGMHEA 317

  Fly   350 KQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMI 414
            |.||:||||||||||::.:||||||:||||||||||||||||||||||||||||:|.|.||:|:|
Human   318 KLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVI 382

  Fly   415 GGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMAT 479
            |||||||||.||||.:.|||||:|||||||:|::||.|  |...|:.|.||||||||||||||.|
Human   383 GGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT--MSGFSNTEEEQTLNQLLVEMDGMGT 445

  Fly   480 KEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLA 544
            .:.|::|||||||||||.||:||||.|||:.||||||.||:||||:||.|:||....|.:|||||
Human   446 TDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLA 510

  Fly   545 RLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHE 609
            .||||||||||||:||||||||||.....|.:.|.||||||::.||.|:|..||..|:||:|:||
Human   511 ELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHE 575

  Fly   610 SGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVF 674
            ||||||||||.:::.::||:|.|||:.||||||..|.:|||::||:||::|||||||||:|.|.|
Human   576 SGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSF 640

  Fly   675 NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMID 739
            |.:|:|||:||.|||:||||.:|:|||...:|||...:|.|    |.||. |::|||:.::.|:|
Human   641 NEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQE----GLMGI-GRRPFSQGLQQMMD 700

  Fly   740 NEARHVVASAYQTTEGILTTHRDKLEKLAEAL 771
            :|||.:||.||:.||.:|..:.|||:  |.||
Human   701 HEARLLVAKAYRHTEKVLQDNLDKLQ--ARAL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	39/106 (37%)
		FtsH_fam	333..787	CDD:273520	288/441 (65%)
		AAA	378..513	CDD:278434	101/134 (75%)
		Peptidase_M41	595..785	CDD:279742	98/177 (55%)
SPG7	NP_001350779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..133		5/29 (17%)
		FtsH_ext	145..242	CDD:310823	42/112 (38%)
		TIP49	265..729	CDD:332389	294/475 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2789
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31133
Inparanoid	1	1.050	671	1.000	Inparanoid score	I742
Isobase	1	0.950	-	0	Normalized mean entropy	S812
OMA	1	1.010	-	-		QHG48979
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0005483
OrthoInspector	1	1.000	-	-		oto89312
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3185
SonicParanoid	1	1.000	-	-		X4433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.060