DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and afg3l1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_005163264.1	Gene:	afg3l1 / 570430	ZFINID:	ZDB-GENE-121214-51	Length:	751	Species:	Danio rerio

Alignment Length:	638	Identity:	278/638 - (43%)
Similarity:	387/638 - (60%)	Gaps:	73/638 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 VSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDV 265
            ::|.:|||..|..|.|:.|.: .:.:.|.:||...|  ...:.|...|::...|.  ||..|...
Zfish   123 ITWKDFVHRYLDRGLVERLEV-VNKQFVRVILERDA--DANEGSYVWFNIGSVDT--FERNLEAA 182

  Fly   266 EKRLGIKDG--VPVTYDRQTDTTGRILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTL 328
            ...||::..  ..|.|..::|  |..||..:...||                     :|...|||
Zfish   183 HYELGLEPSHRAAVVYTSESD--GSFLMSFIPTLLL---------------------IGFLLFTL 224

  Fly   329 -VDPFDGGRG----------------------VLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLG 370
             ..|..||.|                      |.|:||||..|||.|:.|||::||:|::||.||
Zfish   225 RRGPMGGGMGGRRGGLFGMSESTAKMMKDSIEVKFKDVAGCEEAKVEIMEFVNFLKNPQQYQDLG 289

  Fly   371 AKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPC 435
            ||:|:||:|.||||.||||||||.|.||.|||:::|||||:||..|:|.|||||:|...:|.|||
Zfish   290 AKIPKGAVLSGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDMFALARKNAPC 354

  Fly   436 IIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALL 500
            |::||||||:|::|.|...   |.:.|.|.|||||||||||..:...|::||.|||.|:||.||:
Zfish   355 ILFIDEIDAVGKKRGGGNF---GGNSEQENTLNQLLVEMDGFNSSTNVVVLAGTNRPDVLDPALM 416

  Fly   501 RPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPT----TFSQRLARLTPGFSGADIANVCNE 561
            |||||||.|.:..|.:..|..||:.||..:||:  |:    ..::::|..||||:||||||||||
Zfish   417 RPGRFDRQIYLGPPDIKGRASIFKVHLRPLKLD--PSVDRDAIARKMAAATPGFTGADIANVCNE 479

  Fly   562 AALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILL 626
            |||.|||.....||.|:.|.|::|::||.||::..|...|:|.:||||:|||:|||.|.::|.||
Zfish   480 AALIAARYLNESVSVKHFEQAIDRVIGGLEKKTQVLQPTEKKTVAYHEAGHAVVGWFLQHADPLL 544

  Fly   627 KVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKI 691
            ||:|:|| ...||:|||.|.||:||::|:|||:|||.||||.||.:.||:|||||.:||:|||:.
Zfish   545 KVSIIPR-GKGLGYAQYLPKEQYLYTREQLFDRMCMMLGGRVAEQVFFNKITTGAHDDLKKVTQS 608

  Fly   692 AYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGI 756
            ||:||.:|||::.:|.:   ..|....|..:   .:||:|.|...:||.|.|.:|..||:.|..:
Zfish   609 AYAQIVQFGMSERVGQV---SFDLPRQGETV---LEKPYSEATAELIDEEVRDLVDRAYRRTLEL 667

  Fly   757 LTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVE----FEQ 805
            :|..|::::.:.:.|||||.||...:::|:|..|::......|.||    ||:
Zfish   668 VTEKREQVDMVGKRLLEKEVLDKADMLELLGARPFEEKSTYEEFVEGTGSFEE 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	20/76 (26%)
		FtsH_fam	333..787	CDD:273520	238/479 (50%)
		AAA	378..513	CDD:278434	81/134 (60%)
		Peptidase_M41	595..785	CDD:279742	88/189 (47%)
afg3l1	XP_005163264.1	FtsH_ext	100..191	CDD:284011	20/72 (28%)
		FtsH_fam	206..698	CDD:273520	247/524 (47%)
		AAA	298..428	CDD:278434	81/132 (61%)
		Peptidase_M41	514..696	CDD:279742	88/188 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820