Protein Alignment Spg7 and afg3l1

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_005163264.1
• Gene: afg3l1 / 570430
• ZFINID: ZDB-GENE-121214-51
• Length: 751
• Species: Danio rerio
• Alignment Length: 638
• Identity: 278/638 - (43%)
• Similarity: 387/638 - (60%)
• Gaps: 73/638 - (11%)

  Fly   201 VSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDV 265
            ::|.:|||..|..|.|:.|.: .:.:.|.:||...|  ...:.|...|::...|.  ||..|...
Zfish   123 ITWKDFVHRYLDRGLVERLEV-VNKQFVRVILERDA--DANEGSYVWFNIGSVDT--FERNLEAA 182

  Fly   266 EKRLGIKDG--VPVTYDRQTDTTGRILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTL 328
            ...||::..  ..|.|..::|  |..||..:...||                     :|...|||
Zfish   183 HYELGLEPSHRAAVVYTSESD--GSFLMSFIPTLLL---------------------IGFLLFTL 224

  Fly   329 -VDPFDGGRG----------------------VLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLG 370
             ..|..||.|                      |.|:||||..|||.|:.|||::||:|::||.||
Zfish   225 RRGPMGGGMGGRRGGLFGMSESTAKMMKDSIEVKFKDVAGCEEAKVEIMEFVNFLKNPQQYQDLG 289

  Fly   371 AKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPC 435
            ||:|:||:|.||||.||||||||.|.||.|||:::|||||:||..|:|.|||||:|...:|.|||
Zfish   290 AKIPKGAVLSGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDMFALARKNAPC 354

  Fly   436 IIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALL 500
            |::||||||:|::|.|...   |.:.|.|.|||||||||||..:...|::||.|||.|:||.||:
Zfish   355 ILFIDEIDAVGKKRGGGNF---GGNSEQENTLNQLLVEMDGFNSSTNVVVLAGTNRPDVLDPALM 416

  Fly   501 RPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPT----TFSQRLARLTPGFSGADIANVCNE 561
            |||||||.|.:..|.:..|..||:.||..:||:  |:    ..::::|..||||:||||||||||
Zfish   417 RPGRFDRQIYLGPPDIKGRASIFKVHLRPLKLD--PSVDRDAIARKMAAATPGFTGADIANVCNE 479

  Fly   562 AALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILL 626
            |||.|||.....||.|:.|.|::|::||.||::..|...|:|.:||||:|||:|||.|.::|.||
Zfish   480 AALIAARYLNESVSVKHFEQAIDRVIGGLEKKTQVLQPTEKKTVAYHEAGHAVVGWFLQHADPLL 544

  Fly   627 KVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKI 691
            ||:|:|| ...||:|||.|.||:||::|:|||:|||.||||.||.:.||:|||||.:||:|||:.
Zfish   545 KVSIIPR-GKGLGYAQYLPKEQYLYTREQLFDRMCMMLGGRVAEQVFFNKITTGAHDDLKKVTQS 608

  Fly   692 AYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGI 756
            ||:||.:|||::.:|.:   ..|....|..:   .:||:|.|...:||.|.|.:|..||:.|..:
Zfish   609 AYAQIVQFGMSERVGQV---SFDLPRQGETV---LEKPYSEATAELIDEEVRDLVDRAYRRTLEL 667

  Fly   757 LTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVE----FEQ 805
            :|..|::::.:.:.|||||.||...:::|:|..|::......|.||    ||:
Zfish   668 VTEKREQVDMVGKRLLEKEVLDKADMLELLGARPFEEKSTYEEFVEGTGSFEE 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	271/615 (44%)
afg3l1	XP_005163264.1	HflB	107..699	CDD:440233	271/615 (44%)