Protein Alignment Spg7 and PSMC3

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_002795.2
• Gene: PSMC3 / 5702
• HGNCID: 9549
• Length: 439
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 71/372 - (19%)
• Similarity: 119/372 - (31%)
• Gaps: 141/372 - (37%)

  Fly   119 MILLPMV--------PAIAAGNTVVIKPSELSE----NVAATFEK-LIPKYFESKYVTVVNGGI- 169
            ::||.::        |..:.|.|.::   .|.|    ::|...|: |.||.|         ||:
Human     4 VLLLSLIGFCWAQYDPHTSDGRTAIV---HLFEWRWVDIAKECERYLAPKGF---------GGVQ 56

  Fly   170 --PETTDLL--------KERFDHILY----------------TGCPPV-AKIIMTAAAKHLTPVT 207
              |...:::        .||:..|.|                |.|..| .:|.:.|...|:
Human    57 VSPPNENIVIHNPSRPWWERYQPISYKICTRSGNEDEFRDMVTRCNNVGVRIYVDAVINHM---- 117

  Fly   208 LELGGKCPVVVEDDADIDISAKRIAWGKWLNCGQTCLAPDYILVNSTVKPKLVAAIRKYVNEFYG 272
              .|...|.                 |....||      .|:..|:...|.:..:...:.:....
Human   118 --CGSGNPA-----------------GTSSTCG------SYLNPNNREFPAVPYSAWDFNDNKCN 157

  Fly   273 EDVKASKDYARMINQRHFDRISGLLDKTQGAVLIGGERDRADLYIPPTVLD-----VEKSDPFMH 332
            .::....|..::.|    .|:|||||       :..|:|    |:...|:|     ::.|:.|.:
Human   158 GEISNYNDAYQVRN----CRLSGLLD-------LALEKD----YVRTKVIDLGGEAIKGSEYFGN 207

  Fly   333 DEI----FGPVLPIITVQSFSESLEYIAD-----GEKPL-AAYIFTRNEAKVKRLLNETSSGG-- 385
            ..:    ||..|..:..:...|.:.|:.:     |..|. .|.:|..|..      |:...|.
Human   208 GRVTEFKFGAKLGTVIRKWNGEKMSYLKNWGEGWGLVPSDRALVFVDNHD------NQRGHGAGG 266

  Fly   386 -------------VTVNDVLMHITVDTLPFGGVGVSGMGRYRGKYGF 419
                         :.|..:|.|      |:|...|  |..||....|
Human   267 SSILTFWDARMYKMAVGFMLAH------PYGFTRV--MSSYRWNRNF 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	55/289 (19%)
PSMC3	NP_002795.2	PRK03992	39..432	CDD:179699	64/334 (19%)