Protein Alignment Spg7 and afg3l1

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001015906.1
• Gene: afg3l1 / 548660
• XenbaseID: XB-GENE-1014910
• Length: 778
• Species: Xenopus tropicalis
• Alignment Length: 829
• Identity: 338/829 - (40%)
• Similarity: 469/829 - (56%)
• Gaps: 127/829 - (15%)

  Fly    32 IGRELS--LLQLSRRQVMQLQAEY----------KAIVGLIARSLQLTPKEVRLMHLRSLSST-A 83
            |||.:|  :.::|||  :::::.|          ::|...|.:|.:..|         .|||. .
 Frog     5 IGRLVSAGVFEVSRR--LRVRSLYGRAVLRECAGRSITTHICQSWRWNP---------CLSSVFC 58

  Fly    84 KPPTASDGKTEKHEQPEKGSAKAK-DDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGE- 146
            |||...:...:|:|: :.||.||. :.:...|:.......|..::|..|.:..|........|:
 Frog    59 KPPKGFEKYFQKNEK-DSGSGKASPEGTGNAKEEETKKTSGGHNNRRDGNKEESAWWRRLQKGDF 122

  Fly   147 PGEDPNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHML 211
            |.:|       .|.:..::|...:...|      .||.|       |..|  |.::|.||||..|
 Frog   123 PWDD-------KDFRNLAILAAGIASGF------LFFYL-------RDPG--REINWKEFVHLYL 165

  Fly   212 AVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIKDG-- 274
            |.|.|..|.: .:.:.|.:|...|.      .|.......:...:.||..|.:.:..|||:..
 Frog   166 ARGVVDRLEV-VNKQFVRVIPTAGT------TSEKYVWFNIGSVDSFERNLENAQDELGIEPAQR 223

  Fly   275 VPVTYDRQTDTTGRILM-----LLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDG 334
            |.|.|..::|  |..||     ||||..||.|:..              ..||        |..|
 Frog   224 VSVIYSSESD--GSFLMSLIPTLLLVGFLLFSLRR--------------GAMG--------PGRG 264

  Fly   335 GRG-------------------VLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLL 380
            |||                   |.|:||||..|||.|:.|||::||:|::||.||||:||||:|.
 Frog   265 GRGGGLFGVGETTAKMLKGNIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPRGAMLT 329

  Fly   381 GPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAI 445
            ||||.||||||||.|.||.|||:::|||||:||..|:|.|||||:|...:|.||||::||||||:
 Frog   330 GPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDMFAMARKNAPCILFIDEIDAV 394

  Fly   446 GRQRSGTESMGQGSSG---ESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDR 507
            ||:|      |:|:.|   |.|.|||||||||||..:...|::||.|||.||||.||:|||||||
 Frog   395 GRKR------GRGNFGGQSEQENTLNQLLVEMDGFNSSTNVVILAGTNRPDILDPALMRPGRFDR 453

  Fly   508 HILIDLPTLAERKEIFEKHLSSVKLESPPT--TFSQRLARLTPGFSGADIANVCNEAALHAARNT 570
            .|.|..|.:..|..||:.||..:||:...:  ..|::||.|||||:|||||||||||||.|||..
 Frog   454 QIYIGPPDIKGRASIFKVHLRPLKLDESVSKEALSRKLAALTPGFTGADIANVCNEAALIAARYL 518

  Fly   571 QMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTS 635
            :..|..|:...|:||::||.||::..|...|:|.:||||:|||:|||.|.::|.||||:|:|| .
 Frog   519 KDYVVEKHFVQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVVGWYLQHADPLLKVSIIPR-G 582

  Fly   636 LALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFG 700
            ..||:|||.|.||:||::|:|||:|||.||||.:|.|.|:|||||||:||:|||:.||:||.:||
 Frog   583 KGLGYAQYLPKEQYLYTREQLFDRMCMMLGGRVSEQLFFSRITTGAQDDLKKVTQSAYAQIVQFG 647

  Fly   701 MNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLE 765
            |::.||.:   ..|....|..:   .:||:|.|...:||.|||:::.|||:.|..:||..:|::|
 Frog   648 MSEKLGQV---SFDLPRQGEML---AEKPYSEATAELIDQEARNLINSAYERTLELLTRCKDQVE 706

  Fly   766 KLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVEFEQSLKNLSTDT 814
            |:|:.|||||.|:...:::|:|..|:. .|...|  ||.:...:|..||
 Frog   707 KVAKRLLEKEVLEKSDMIELLGARPFP-EKSSYE--EFVEGTGSLEEDT 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	294/640 (46%)
afg3l1	NP_001015906.1	HflB	135..729	CDD:440233	296/652 (45%)