DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and CG6512

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	315/811 - (38%)
Similarity:	460/811 - (56%)	Gaps:	111/811 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAK---AKDDS 110
            |..|...::..:.:.:||..|              |||              ||..|   |...|
  Fly    44 LPTELSPLLRYVVKQIQLLCK--------------KPP--------------KGFEKYFEAGGKS 80

  Fly   111 SKEKKSAVAAEDGDK-----SSRAAGEE-AASTPT--------------------SSSTIGEPGE 149
            |.:.|.:|    |||     ||::|.|: :.|||.                    |:|:.|..|:
  Fly    81 SGQPKGSV----GDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDWNFGMFSNSSRGPAGK 141

  Fly   150 DPN--------KNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEF 206
            ..|        :|....|.: |.:|..|:..:..:..| |||           |...:.:||.||
  Fly   142 GGNSLGGRPLGENGGGGDRE-RWILLGAIGAVVLVGSF-AFF-----------EMGYKEISWKEF 193

  Fly   207 VHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI 271
            |:..|:.|.|::|.: .:.:.|.:.|.:.:     ...|.:....:...:.||..|...:...|.
  Fly   194 VNSYLSKGVVEKLEV-VNKKWVRVRLQQNS-----NSGSGVLWFNIGSVDSFERNLEAAQTEQGT 252

  Fly   272 K--DGVPVTYDRQTDT---TGRILMLLLVCALLMSI---ATRMKSIKSPLSMDSFNQMGRAKFTL 328
            :  :.|||.|..:.:.   ||.:..||::..|:..:   |..|...:.......|..:.::...|
  Fly   253 ESINFVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKL 317

  Fly   329 VDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKA 393
            .:|.:.|.|  |:||||..|||.|:.|||::||:|::|..||||:|:||:|.||||.||||||||
  Fly   318 TNPNEIGVG--FKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKA 380

  Fly   394 VATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQG 458
            .|.||.|||::::||||:||..|:|.:||||:|...:|.||||::||||||:||:|.|...   |
  Fly   381 TAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTF---G 442

  Fly   459 SSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIF 523
            ...|.|.|||||||||||..|...|::||:|||.|||||||:|||||||.|.:..|.:..|..||
  Fly   443 GHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIF 507

  Fly   524 EKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVG 588
            :.||.::|........|:::|.|||||:|||||||||||||.|||:::..:..|:.|.|:||::.
  Fly   508 KVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIA 572

  Fly   589 GTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSK 653
            |.||:::.|:..|::.:|:||:|||:.||.|.::|.||||:|:|| ...||:|||.|.:.:|.||
  Fly   573 GMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPR-GKGLGYAQYLPKDHYLLSK 636

  Fly   654 EELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEG 718
            |:|||:|||.||||.||.|.|||||||||:||:|:|.|||||:.:||||:.:|.:   ..|..:.
  Fly   637 EQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQV---SFDVGQA 698

  Fly   719 GGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVV 783
            |..:.|   ||:|.....:||||.|.::..|::.|..:||.|::.::|:||.||:.|.|..|.::
  Fly   699 GDPVFS---KPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRDDMI 760

  Fly   784 QLIGPPPYDLGKRQVESVEFEQSLKNLSTDT 814
            :|:||.|:   |.:....||.:...:...||
  Fly   761 ELLGPRPF---KEKSTYEEFVEGTGSFEEDT 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	21/106 (20%)
		FtsH_fam	333..787	CDD:273520	236/453 (52%)
		AAA	378..513	CDD:278434	83/134 (62%)
		Peptidase_M41	595..785	CDD:279742	89/189 (47%)
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	23/113 (20%)
		FtsH_fam	271..764	CDD:273520	246/504 (49%)
		AAA	365..496	CDD:278434	83/133 (62%)
		Peptidase_M41	580..762	CDD:279742	89/188 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I40
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.900