DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spg7 and bcs1l

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_957476.2	Gene:	bcs1l / 394157	ZFINID:	ZDB-GENE-040426-938	Length:	420	Species:	Danio rerio

Alignment Length:	311	Identity:	79/311 - (25%)
Similarity:	130/311 - (41%)	Gaps:	85/311 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 RMKSIKSPLSMD----------SFNQMGRAKFTLVDPF----------DGGRGVLFRDV------ 343
            |::.::....||          :|..:||.:.|..:..          :.||.|::..:
Zfish   114 RVERVREKQMMDLHTGTPWESVTFTALGRDRQTFFNILQEARELALKQEEGRTVMYTAMGAEWRP 178

  Fly   344 ----------------AGLSE-AKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLA 391
                            :|::| ...:||||:.   :|:.|...|....||.||.|||||||:...
Zfish   179 FGFPRRRRPLSSVVLESGVAERIVDDVKEFIG---NPKWYTDRGIPYRRGYLLYGPPGCGKSSFI 240

  Fly   392 KAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDA--IGRQRSGTES 454
            .|:|.|.......|:.|:     ..|...|:..|.....:::  ||.::::||  :.|:...||:
Zfish   241 TALAGELGYSICLMSLSD-----RSLSDDRLNHLLSVAPQQS--IILLEDVDAAFVSRELLPTEN 298

  Fly   455 ----MGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPT 515
                .|.|     ..|.:.||..:||:|:.|..::..:||..:.||.||:||||      :||
Zfish   299 PLAYQGMG-----RLTFSGLLNALDGVASSEARIVFMTTNFIERLDPALVRPGR------VDL-- 350

  Fly   516 LAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHA 566
                 :.:..|.|..:|       :|...|..|..|.|: |:..:|.||.|
Zfish   351 -----KQYVGHCSHWQL-------TQMFRRFYPQESAAE-ADHFSEQALAA 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011
		FtsH_fam	333..787	CDD:273520	72/263 (27%)
		AAA	378..513	CDD:278434	43/140 (31%)
		Peptidase_M41	595..785	CDD:279742
bcs1l	NP_957476.2	BCS1_N	24..176	CDD:214980	10/61 (16%)
		AAA	223..355	CDD:214640	47/156 (30%)
		AAA	226..355	CDD:278434	45/153 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810