DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and YME1L

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	804	Identity:	259/804 - (32%)
Similarity:	397/804 - (49%)	Gaps:	150/804 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VRNALQRGGSQLIQLRSATGQPPRIGRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKE-- 70
            :||.|.|..:      |..|...|..|...:  |.||.|..:.|:..:::..: |.:::|.:|
  Fly    57 LRNLLSRSSA------SIQGMVERAARLNGI--LDRRLVDDVLAKVTSMLPSM-RDVRVTLEESA 112

  Fly    71 -----VRLMHLR---SLSSTA-KPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKS 126
                 |:|.:.:   ||:..| ..||.::.|.    .|.......:...|:::.:.:.   |.|:
  Fly   113 TQIGRVQLQNYQFEVSLTGAAGSVPTGANVKV----IPTITPGLLRPLFSQQQLNQIR---GFKT 170

  Fly   127 SRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRS 191
            .|:...|....||.:|.:        ||:..|.                               .
  Fly   171 DRSIEAEQKRNPTMTSRL--------KNALANS-------------------------------P 196

  Fly   192 ERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPD------MEMVTIILHEGAVIKGRKVSSTIFHM 250
            :|.:|.|           .|...:::.|:.:.:      .|.:.|...||             ::
  Fly   197 QRLDGDT-----------PLQAEKLRRLLAKSEEHGFNKAESLKIAFAEG-------------YL 237

  Fly   251 AVADANKFEEKLRDVEKRLGIKDGVPVTYDRQTDTTGRILMLLLVCALLMSIATR-----MKSIK 310
            |.|::..            ..|.|..:.|.:...|   |:::::...:.:|..|.     .:||
  Fly   238 AAANSED------------SPKSGKTMKYLKTLQT---IVVIVVFLGIFLSFFTTSNGSVFRSI- 286

  Fly   311 SPLSMDSFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPR 375
                     |:|..  ..|||.:  ..|.|.||.|..|||||:||.|::||||||:..||.|:|:
  Fly   287 ---------QLGNQ--VEVDPEE--INVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPK 338

  Fly   376 GALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYID 440
            |.||:||||.||||||:|||.||:|||....|.||.|::.|.||.|||||||..|.||||:|:||
  Fly   339 GVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFID 403

  Fly   441 EIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRF 505
            |||::|.:|  |.|:   ....:.||:||||.||||.....||::|.:|||.|.||:||||||||
  Fly   404 EIDSVGAKR--TNSV---LHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRF 463

  Fly   506 DRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNT 570
            |..:::..|....||||...:|:.:..:....   ..|||.|.||:|||:.|:.|:|||.||.:.
  Fly   464 DVEVMVSTPDFTGRKEILSLYLTKILHDEIDL---DMLARGTSGFTGADLENMINQAALRAAIDG 525

  Fly   571 QMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTS 635
            ...||.|:||.|.::::.|.|:::.........:.||||.|||:|.:....|..|.||||:|| .
  Fly   526 AETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPR-G 589

  Fly   636 LALGFAQYTP-SEQHLYSKEELFDKMCMALGGRAAENLVF--NRITTGAQNDLEKVTKIAYSQIK 697
            .:||...|.| .|::..:|.:|...|...:||||||.|||  ::||:||.:||::.|.||...::
  Fly   590 PSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVR 654

  Fly   698 KFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRD 762
            .:||:|.:|   :|..:.::|.|...:.|....     ..:|.|.:.:::.:|:..:.||..|..
  Fly   655 DWGMSDKVG---LRTIEASKGLGTGDTLGPNTI-----EAVDAEIKRILSDSYERAKAILRKHTR 711

  Fly   763 KLEKLAEALLEKETLDYDQVVQLI 786
            :.:.||||||:.||||.|.:..::
  Fly   712 EHKALAEALLKYETLDADDIKAIL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	13/110 (12%)
		FtsH_fam	333..787	CDD:273520	198/457 (43%)
		AAA	378..513	CDD:278434	77/134 (57%)
		Peptidase_M41	595..785	CDD:279742	67/192 (35%)
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/516 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850