DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and Afg3l1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001101926.3	Gene:	Afg3l1 / 361436	RGDID:	1309722	Length:	789	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	327/800 - (40%)
Similarity:	446/800 - (55%)	Gaps:	121/800 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVA 119
            |:.|.:.|..|....:.||... |.|..:|||              ||..|    ..|.||:..:
  Rat    44 ALQGRLGRCSQQLALQGRLTSF-SPSLYSKPP--------------KGFEK----FFKNKKNRKS 89

  Fly   120 AEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSN-------------ENDEKMRSVLTKAVL 171
            |..|  :|.|..:|    |.:|...|:.|....|..:             .:|:..||:   |||
  Rat    90 ASPG--NSVAPNKE----PKNSGPGGDGGHRGGKGDDFTWWKRMQKGEFPWDDKDFRSL---AVL 145

  Fly   172 WLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGA 236
            .......|:.|:.        |..|  :.::|..||.:.||.|.|..|.: .:.:.|.:|...|.
  Rat   146 GAGVASGFLYFYF--------RDPG--KEITWKHFVQYYLARGLVDRLEV-VNKQFVRVIPVPGT 199

  Fly   237 VIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIK--DGVPVTYDRQTDTTGRILMLLLVCALL 299
                  .|.......:...:.||..|...:..||::  :.|.|.|..::|  |.:|..|:...:|
  Rat   200 ------TSEKFVWFNIGSVDTFERNLESAQWELGVEPTNQVSVVYTTESD--GSLLRSLVPTLVL 256

  Fly   300 MSIAT-RMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------------VLFRDVA 344
            :.|.. .||  :.|        ||..:        ||||                   |.|.|||
  Rat   257 VGILLYAMK--RGP--------MGTGR--------GGRGGGLFSVGETTAKILKNNIDVRFADVA 303

  Fly   345 GLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSE 409
            |..|||.|:.|||::||:|::||.||||:|:||:|.||||.||||||||.|.||:|||:::||||
  Rat   304 GCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAMLTGPPGTGKTLLAKATAGEAKVPFITVNGSE 368

  Fly   410 FIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSG---ESEQTLNQLL 471
            |:||..|:|.|||||:|...:|.||||::|||||||||:|      |:|..|   |.|.||||:|
  Rat   369 FLEMFVGVGPARVRDMFAMARKHAPCILFIDEIDAIGRKR------GRGHLGGQSEQENTLNQML 427

  Fly   472 VEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPP 536
            |||||..:...|::||.|||.||||.||.|||||||.|.|..|.:..|..||:.||..:||:...
  Rat   428 VEMDGFNSTTNVVVLAGTNRPDILDPALTRPGRFDRQIYIGPPDIKGRSSIFKVHLRPLKLDESL 492

  Fly   537 T--TFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
            |  ..|::||.|||||:||||:||||||||.|||:....|..::.|.|:||::||.||::..|..
  Rat   493 TRDALSRKLAALTPGFTGADISNVCNEAALIAARHLSPSVQERHFEQAIERVIGGLEKKTQVLQP 557

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMAL 664
            :|:..:||||:|||:|||.|.::|.||||:|:|| ...||:|||.|.||:||::|:|||:|||.|
  Rat   558 SEKTTVAYHEAGHAVVGWFLEHADPLLKVSIIPR-GKGLGYAQYLPREQYLYTREQLFDRMCMML 621

  Fly   665 GGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKP 729
            |||.||.|.|.:||||||:||.|||:.||:||.:|||::.||.:   ..|....|..|   .:||
  Rat   622 GGRVAEQLFFGQITTGAQDDLRKVTQSAYAQIVQFGMSEKLGQV---SFDFPRQGETM---VEKP 680

  Fly   730 FSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLG 794
            :|.|...:||.|.|.:|.|||..|..:||..|:::||:...|||||.|:...:::|:||.|: ..
  Rat   681 YSEATAQLIDEEVRCLVRSAYNRTLELLTQCREQVEKVGRRLLEKEVLEKADMIELLGPRPF-AE 744

  Fly   795 KRQVESVEFEQSLKNLSTDT 814
            |...|  ||.:...:|..||
  Rat   745 KSTYE--EFVEGTGSLEEDT 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	22/106 (21%)
		FtsH_fam	333..787	CDD:273520	249/477 (52%)
		AAA	378..513	CDD:278434	85/137 (62%)
		Peptidase_M41	595..785	CDD:279742	93/189 (49%)
Afg3l1	NP_001101926.3	FtsH_ext	143..233	CDD:284011	24/106 (23%)
		FtsH_fam	247..738	CDD:273520	258/521 (50%)
		AAA	337..468	CDD:278434	84/136 (62%)
		Peptidase_M41	554..736	CDD:279742	93/188 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820