Protein Alignment Spg7 and Afg3l1

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001101926.3
• Gene: Afg3l1 / 361436
• RGDID: 1309722
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 800
• Identity: 327/800 - (40%)
• Similarity: 446/800 - (55%)
• Gaps: 121/800 - (15%)

  Fly    55 AIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVA 119
            |:.|.:.|..|....:.||... |.|..:|||              ||..|    ..|.||:..:
  Rat    44 ALQGRLGRCSQQLALQGRLTSF-SPSLYSKPP--------------KGFEK----FFKNKKNRKS 89

  Fly   120 AEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSN-------------ENDEKMRSVLTKAVL 171
            |..|  :|.|..:|    |.:|...|:.|....|..:             .:|:..||:   |||
  Rat    90 ASPG--NSVAPNKE----PKNSGPGGDGGHRGGKGDDFTWWKRMQKGEFPWDDKDFRSL---AVL 145

  Fly   172 WLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGA 236
            .......|:.|:.        |..|  :.::|..||.:.||.|.|..|.: .:.:.|.:|...|.
  Rat   146 GAGVASGFLYFYF--------RDPG--KEITWKHFVQYYLARGLVDRLEV-VNKQFVRVIPVPGT 199

  Fly   237 VIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIK--DGVPVTYDRQTDTTGRILMLLLVCALL 299
                  .|.......:...:.||..|...:..||::  :.|.|.|..::|  |.:|..|:...:|
  Rat   200 ------TSEKFVWFNIGSVDTFERNLESAQWELGVEPTNQVSVVYTTESD--GSLLRSLVPTLVL 256

  Fly   300 MSIAT-RMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------------VLFRDVA 344
            :.|.. .||  :.|        ||..:        ||||                   |.|.|||
  Rat   257 VGILLYAMK--RGP--------MGTGR--------GGRGGGLFSVGETTAKILKNNIDVRFADVA 303

  Fly   345 GLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSE 409
            |..|||.|:.|||::||:|::||.||||:|:||:|.||||.||||||||.|.||:|||:::||||
  Rat   304 GCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAMLTGPPGTGKTLLAKATAGEAKVPFITVNGSE 368

  Fly   410 FIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSG---ESEQTLNQLL 471
            |:||..|:|.|||||:|...:|.||||::|||||||||:|      |:|..|   |.|.||||:|
  Rat   369 FLEMFVGVGPARVRDMFAMARKHAPCILFIDEIDAIGRKR------GRGHLGGQSEQENTLNQML 427

  Fly   472 VEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPP 536
            |||||..:...|::||.|||.||||.||.|||||||.|.|..|.:..|..||:.||..:||:...
  Rat   428 VEMDGFNSTTNVVVLAGTNRPDILDPALTRPGRFDRQIYIGPPDIKGRSSIFKVHLRPLKLDESL 492

  Fly   537 T--TFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
            |  ..|::||.|||||:||||:||||||||.|||:....|..::.|.|:||::||.||::..|..
  Rat   493 TRDALSRKLAALTPGFTGADISNVCNEAALIAARHLSPSVQERHFEQAIERVIGGLEKKTQVLQP 557

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMAL 664
            :|:..:||||:|||:|||.|.::|.||||:|:|| ...||:|||.|.||:||::|:|||:|||.|
  Rat   558 SEKTTVAYHEAGHAVVGWFLEHADPLLKVSIIPR-GKGLGYAQYLPREQYLYTREQLFDRMCMML 621

  Fly   665 GGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKP 729
            |||.||.|.|.:||||||:||.|||:.||:||.:|||::.||.:   ..|....|..|   .:||
  Rat   622 GGRVAEQLFFGQITTGAQDDLRKVTQSAYAQIVQFGMSEKLGQV---SFDFPRQGETM---VEKP 680

  Fly   730 FSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLG 794
            :|.|...:||.|.|.:|.|||..|..:||..|:::||:...|||||.|:...:::|:||.|: ..
  Rat   681 YSEATAQLIDEEVRCLVRSAYNRTLELLTQCREQVEKVGRRLLEKEVLEKADMIELLGPRPF-AE 744

  Fly   795 KRQVESVEFEQSLKNLSTDT 814
            |...|  ||.:...:|..||
  Rat   745 KSTYE--EFVEGTGSLEEDT 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	284/636 (45%)
Afg3l1	NP_001101926.3	HflB	145..739	CDD:440233	285/643 (44%)