Protein Alignment Spg7 and Spg7

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001386039.1
• Gene: Spg7 / 353231
• RGDID: 727940
• Length: 781
• Species: Rattus norvegicus
• Alignment Length: 778
• Identity: 378/778 - (48%)
• Similarity: 517/778 - (66%)
• Gaps: 81/778 - (10%)

  Fly    20 IQLRSATGQPPRIGRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAK 84
            |.|.:|.|..|:     |||      :..|...::.:.||:.:. .:.|..:||..|.  .||..
  Rat    50 IGLAAAGGHTPQ-----SLL------LRILTPSFEGVSGLLLKR-HIVPSAIRLWQLS--GSTLY 100

  Fly    85 PPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGE 149
            ..|:  |..:|::..:|...||.:|..:|::   ..|..|:..|
  Rat   101 FNTS--GLKQKNKDDDKPKGKAPEDDEEERR---RKEREDQMYR--------------------- 139

  Fly   150 DPNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVG 214
                      |::|:        ||.|.:.::..:.|.|        |...:||.:||:.|||.|
  Rat   140 ----------ERLRT--------LFIIAIVMSLLNSLST--------SGGSISWADFVNEMLAKG 178

  Fly   215 EVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPV 277
            ||:.:.:.|:.::|.:.||.|||:.||...:.::.|.||:.:|||||||..|..|.|  ||.:||
  Rat   179 EVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIESKDRIPV 243

  Fly   278 TYDRQTDTTGRILMLLLVCALLMSIATRMKSIKSPLSMD----SFNQMGRAKFTLVDPFDGGRGV 338
            :|.| |...|..|..|.:.|:.::|...:..:......:    :|||:..|:||:||. ..|:||
  Rat   244 SYKR-TGFFGNALYALGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG-KTGKGV 306

  Fly   339 LFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFL 403
            .|:||||:.|||.||:||||||||||::.:||||||:||||||||||||||||||||||||||||
  Rat   307 SFQDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFL 371

  Fly   404 SMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLN 468
            :|.|.||:|:||||||||||.||||.:.|||||:|||||||:|::||  .||...|:.|.|||||
  Rat   372 AMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRS--TSMSGFSNTEEEQTLN 434

  Fly   469 QLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLE 533
            |||||||||.|.:.|::||||||||:||.||:||||.|||:.||||||.||:||||:||..:||.
  Rat   435 QLLVEMDGMGTADHVIVLASTNRADVLDNALMRPGRLDRHVFIDLPTLQERREIFEQHLKGLKLT 499

  Fly   534 SPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALS 598
            .|.:.:|||||.||||||||||||:||||||||||.....|.:.|.||||||::.||.|:|..||
  Rat   500 QPSSFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTFNFEYAVERVIAGTAKKSKILS 564

  Fly   599 LAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMA 663
            ..|::|:|:||||||||||:|.:::.::||:|.|||:.||||:|..|.:|:|::||:||::||||
  Rat   565 KEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQMLPRDQYLFTKEQLFERMCMA 629

  Fly   664 LGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKK 728
            |||||||.:.|:|:|:|||:||.|||:||||.:|:|||..::||:...:|.|    |.:|. |::
  Rat   630 LGGRAAEAISFSRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPVSFPEAQE----GLVGI-GRR 689

  Fly   729 PFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPY 791
            |||:.::.|:|:|||.:||.||:.||.:|..:.|||:.||.||||||.::|:.:..||||||:
  Rat   690 PFSQGLQQMMDHEARLLVARAYRHTEKVLLDNLDKLQALANALLEKEVINYEDIEALIGPPPH 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	341/615 (55%)
Spg7	NP_001386039.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..134		7/28 (25%)
		HflB	147..749	CDD:440233	317/607 (52%)
		Interaction with PPIF. /evidence=ECO:0000250|UniProtKB:Q9UQ90	701..781		37/79 (47%)