DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and Afg3l2

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001128336.1	Gene:	Afg3l2 / 307350	RGDID:	1305259	Length:	802	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	340/830 - (40%)
Similarity:	467/830 - (56%)	Gaps:	100/830 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RGGSQLIQLRSATGQPPRIGRELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRS 78
            |||.:       .|.||.:... ..|...||..::...:|..:....:||..|  ::|...:.|.
  Rat    11 RGGCR-------RGLPPLLVPS-GCLGPGRRPCLRTLYQYATVQTANSRSSLL--RDVIAAYQRF 65

  Fly    79 LSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSST 143
            .|   :||..    .||:....|...||     .|.|.||    |:|.     |...|.|.||.
  Rat    66 CS---RPPKG----FEKYFPNGKNGKKA-----SESKEAV----GEKK-----ESQLSGPQSSG- 108

  Fly   144 IGEPGEDPNKNSNENDEKMRSVLTKA------------VLWLFTIYMFVAFFSLLITPRSERPEG 196
             |..|....:...:.|....|...|.            .||....:..|..:.|.        :.
  Rat   109 -GASGGGGKRRGKKEDSHWWSRFQKGDFPWDDKDFRMYFLWTALFWSGVMIYFLF--------KS 164

  Fly   197 STRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAV-IKGRKVSSTIFHMAVADANKFEE 260
            |.|.::|.:||::.|:.|.|..|.: .:...|.:....|.. :.|:.|   .|::...|.  ||.
  Rat   165 SGREITWKDFVNNYLSKGVVDRLEV-VNKRFVRVTFTPGKTPVDGQYV---WFNIGSVDT--FER 223

  Fly   261 KLRDVEKRLGI--KDGVPVTYDRQTDTTGRILML---LLVCALLMSIATRMKSI-KSPLSMDSFN 319
            .|..:::.|||  ::.|||.|..::|.:..:.||   |::..||.:|......| ::...|....
  Rat   224 NLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLF 288

  Fly   320 QMGR--AKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGP 382
            .:|.  || .|.|..|    |.|:||||..|||.|:.|||::||:|::||.||||:|:||:|.||
  Rat   289 SVGETTAK-VLKDEID----VKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGP 348

  Fly   383 PGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGR 447
            ||.||||||||.|.||.|||::::||||:||..|:|.|||||||...:|.||||::||||||:||
  Rat   349 PGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGR 413

  Fly   448 QRSGTESMGQGSSG---ESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHI 509
            :|      |:|:.|   |.|.|||||||||||..|...|::||.|||.||||.||||||||||.|
  Rat   414 KR------GRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQI 472

  Fly   510 LIDLPTLAERKEIFEKHLSSVKLES--PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQM 572
            .|..|.:..|..||:.||..:||:|  .....:::||.|||||||||:|||||||||.|||:...
  Rat   473 FIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSD 537

  Fly   573 EVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLA 637
            .::.|:.|.|:||::||.||::..|...|:|.:||||:|||:.||.|.::|.||||:|:|| ...
  Rat   538 AINEKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPR-GKG 601

  Fly   638 LGFAQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMN 702
            ||:|||.|.||:||:||:|.|:|||.||||.:|.:.|.|||||||:||.|||:.||:||.:||||
  Rat   602 LGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMN 666

  Fly   703 DTLGPI---YVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKL 764
            :.:|.|   ..|..|...         :||:|.|...|||:|.|.:::.||:.|..:||..:..:
  Rat   667 EKVGQISFDLPRQGDMVL---------EKPYSEATARMIDDEVRILISEAYKRTVALLTEKKADV 722

  Fly   765 EKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESVEFEQSLKNLSTDT 814
            ||:|..|||||.||.:.:|:|:||.|: ..|...|  ||.:...:|..||
  Rat   723 EKVALLLLEKEVLDKNDMVELLGPRPF-TEKSTYE--EFVEGTGSLDEDT 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	25/107 (23%)
		FtsH_fam	333..787	CDD:273520	248/461 (54%)
		AAA	378..513	CDD:278434	87/137 (64%)
		Peptidase_M41	595..785	CDD:279742	93/192 (48%)
Afg3l2	NP_001128336.1	FtsH_ext	145..241	CDD:284011	25/109 (23%)
		FtsH_fam	252..745	CDD:273520	261/513 (51%)
		AAA	344..475	CDD:278434	86/136 (63%)
		Peptidase_M41	561..743	CDD:279742	93/191 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820