DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spg7 and Yme1l1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_038799.1	Gene:	Yme1l1 / 27377	MGIID:	1351651	Length:	715	Species:	Mus musculus

Alignment Length:	511	Identity:	197/511 - (38%)
Similarity:	304/511 - (59%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 RQTDTTGRILMLLLVCALLMSIATRMKS------IKSPLSMDSFNQMGRAKFTLVDPFDGGRGVL 339
            ::|:.:.|...|:|...||..|...:|:      .::...:||          .|||.. .:.|.
Mouse   226 QKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDS----------AVDPVQ-MKNVT 279

  Fly   340 FRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLS 404
            |..|.|:.|||||::|.|::||:|:|:..||.|:|:|.||:||||.||||||:|||.||.|||..
Mouse   280 FEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYY 344

  Fly   405 MNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQ 469
            .:||||.||..|:||:|:|:||:|.|..|||:|:|||:|::|.:|     :.......|.||:||
Mouse   345 ASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR-----IESPMHPYSRQTINQ 404

  Fly   470 LLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLES 534
            ||.||||....|||:::.:||..:.||.||:||||||..:.:..|.:..|.||.:.:|:.:|.:.
Mouse   405 LLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDK 469

  Fly   535 PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
              :...:.:||.|.|||||::.|:.|:|||.||.:.:..|:.|.||::.::::.|.|:||..:..
Mouse   470 --SVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN 532

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTP-SEQHLYSKEELFDKMCMA 663
            ..:.:.||||||||::.:...::..:.|.||:|| ...||.....| :::...::.:|..:|.::
Mouse   533 KNKTITAYHESGHAIIAYYTKDAMPINKATIMPR-GPTLGHVSLLPENDRWNETRAQLLAQMDVS 596

  Fly   664 LGGRAAENLVF--NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGG 726
            :|||.||.|:|  :.|||||.:|.:..||||...:.||||::.||.:...|.            |
Mouse   597 MGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDT------------G 649

  Fly   727 KKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQV 782
            |  .|...:|.|:.|.|.::..:|:..:.||.||..:.:.||||||..||||..::
Mouse   650 K--LSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEI 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011
		FtsH_fam	333..787	CDD:273520	184/453 (41%)
		AAA	378..513	CDD:278434	71/134 (53%)
		Peptidase_M41	595..785	CDD:279742	64/191 (34%)
Yme1l1	NP_038799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..54
		P-loop_NTPase	273..>337	CDD:304359	35/64 (55%)
		FtsH_fam	275..708	CDD:273520	184/451 (41%)
		AAA	317..448	CDD:278434	71/135 (53%)
		Peptidase_M41	528..706	CDD:279742	64/191 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810