DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and yta12

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_596797.1	Gene:	yta12 / 2541079	PomBaseID:	SPBC543.09	Length:	773	Species:	Schizosaccharomyces pombe

Alignment Length:	807	Identity:	305/807 - (37%)
Similarity:	434/807 - (53%)	Gaps:	132/807 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQP 99
            :.|||.||:|....|:                                     .:.|..|||:.|
pombe    49 QFSLLSLSQRSFQSLK-------------------------------------INKGIPEKHKIP 76

  Fly   100 EKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNK------NSNEN 158
             ..|:|....:||..::..:..:.|.:.|..|::    ...|...|..|.||.|      |.|
pombe    77 -LISSKQFSVTSKRSQNGSSGSNSDANGRKNGQK----NDDSKKKGLNGNDPKKVFEIALNGN-- 134

  Fly   159 DEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRP 223
                  .:...:|..:.:|..::            |..:.:.::|.:|....|..|.|:.|:: .
pombe   135 ------TILGGILVAYILYNVLS------------PNANMQEITWQDFRQQFLDKGLVERLVV-V 180

  Fly   224 DMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTT 286
            :..||.:|| .|.|..|    |..::.::...:.|:.||.|.:::|||  .:.|||.|..:..
pombe   181 NRNMVRVIL-RGGVASG----SGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVPVAYHDEVS-- 238

  Fly   287 GRILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------- 337
                    |.|.|:|.|..:..|.|.:.: |....|.|        .||:|
pombe   239 --------VLATLLSFAPTLLIIGSVIYL-SRRASGAA--------GGGQGGIFGIGKSRAKMFN 286

  Fly   338 ------VLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVAT 396
                  :.|.||||:.|||:|:.|||.:||:|:.|:|||||:||||:|.||||.||||||||.|.
pombe   287 HETDIKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAG 351

  Fly   397 EAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQ-GSS 460
            ||.|||||::||||:||..|:|.:||||||...:|.|||||:||||||||:.|.   ..|| ||:
pombe   352 EANVPFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARG---RGGQFGSN 413

  Fly   461 GESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEK 525
            .|.|.|||||||||||..:.|.:::.|.|||.|:||.||||||||||.|.||.|.:..|::||:.
pombe   414 DERESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKV 478

  Fly   526 HLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGT 590
            ||..:|........::|||.||.||:||||.|||||.||.|||:...||...:.|.|:||:..|.
pombe   479 HLKHIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGL 543

  Fly   591 EKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEE 655
            ||:|..||..|:..:|:||:|||:.||.:...|.||||:|:||.. |||:|.|.|.:|:|.|:.:
pombe   544 EKKSRVLSPEEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQ-ALGYASYLPKDQYLMSRGQ 607

  Fly   656 LFDKMCMALGGRAAENLVF--NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPI-YVRDADETE 717
            :.|:|.|||.||.:|.:.|  .:||:||.:|.:|||::|.:.:.::||:.|:|.| |..|..||.
pombe   608 ILDQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETV 672

  Fly   718 GGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQV 782
                     :||||.|...|||.|.|.:|..||:.|:.:|..|:..||.:|:.||:||.:.|::|
pombe   673 ---------QKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEV 728

  Fly   783 VQLIGPPPYDLGKRQVESVEFEQSLKN 809
            ..::||.||......:..:..:...||
pombe   729 ETILGPRPYAYKHLNISELMRQSEYKN 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	24/106 (23%)
		FtsH_fam	333..787	CDD:273520	234/477 (49%)
		AAA	378..513	CDD:278434	87/135 (64%)
		Peptidase_M41	595..785	CDD:279742	80/192 (42%)
yta12	NP_596797.1	FtsH_ext	136..230	CDD:284011	24/111 (22%)
		FtsH_fam	238..733	CDD:273520	244/526 (46%)
		AAA	333..466	CDD:278434	87/135 (64%)
		Peptidase_M41	548..731	CDD:279742	80/192 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910