Protein Alignment Spg7 and yta12

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_596797.1
• Gene: yta12 / 2541079
• PomBaseID: SPBC543.09
• Length: 773
• Species: Schizosaccharomyces pombe
• Alignment Length: 807
• Identity: 305/807 - (37%)
• Similarity: 434/807 - (53%)
• Gaps: 132/807 - (16%)

  Fly    35 ELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQP 99
            :.|||.||:|....|:                                     .:.|..|||:.|
pombe    49 QFSLLSLSQRSFQSLK-------------------------------------INKGIPEKHKIP 76

  Fly   100 EKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNK------NSNEN 158
             ..|:|....:||..::..:..:.|.:.|..|::    ...|...|..|.||.|      |.|
pombe    77 -LISSKQFSVTSKRSQNGSSGSNSDANGRKNGQK----NDDSKKKGLNGNDPKKVFEIALNGN-- 134

  Fly   159 DEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRP 223
                  .:...:|..:.:|..::            |..:.:.::|.:|....|..|.|:.|:: .
pombe   135 ------TILGGILVAYILYNVLS------------PNANMQEITWQDFRQQFLDKGLVERLVV-V 180

  Fly   224 DMEMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTT 286
            :..||.:|| .|.|..|    |..::.::...:.|:.||.|.:::|||  .:.|||.|..:..
pombe   181 NRNMVRVIL-RGGVASG----SGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVPVAYHDEVS-- 238

  Fly   287 GRILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------- 337
                    |.|.|:|.|..:..|.|.:.: |....|.|        .||:|
pombe   239 --------VLATLLSFAPTLLIIGSVIYL-SRRASGAA--------GGGQGGIFGIGKSRAKMFN 286

  Fly   338 ------VLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVAT 396
                  :.|.||||:.|||:|:.|||.:||:|:.|:|||||:||||:|.||||.||||||||.|.
pombe   287 HETDIKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAG 351

  Fly   397 EAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQ-GSS 460
            ||.|||||::||||:||..|:|.:||||||...:|.|||||:||||||||:.|.   ..|| ||:
pombe   352 EANVPFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARG---RGGQFGSN 413

  Fly   461 GESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEK 525
            .|.|.|||||||||||..:.|.:::.|.|||.|:||.||||||||||.|.||.|.:..|::||:.
pombe   414 DERESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKV 478

  Fly   526 HLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGT 590
            ||..:|........::|||.||.||:||||.|||||.||.|||:...||...:.|.|:||:..|.
pombe   479 HLKHIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGL 543

  Fly   591 EKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEE 655
            ||:|..||..|:..:|:||:|||:.||.:...|.||||:|:||.. |||:|.|.|.:|:|.|:.:
pombe   544 EKKSRVLSPEEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQ-ALGYASYLPKDQYLMSRGQ 607

  Fly   656 LFDKMCMALGGRAAENLVF--NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPI-YVRDADETE 717
            :.|:|.|||.||.:|.:.|  .:||:||.:|.:|||::|.:.:.::||:.|:|.| |..|..||.
pombe   608 ILDQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETV 672

  Fly   718 GGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQV 782
                     :||||.|...|||.|.|.:|..||:.|:.:|..|:..||.:|:.||:||.:.|::|
pombe   673 ---------QKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEV 728

  Fly   783 VQLIGPPPYDLGKRQVESVEFEQSLKN 809
            ..::||.||......:..:..:...||
pombe   729 ETILGPRPYAYKHLNISELMRQSEYKN 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	270/635 (43%)
yta12	NP_596797.1	HflB	140..734	CDD:440233	272/643 (42%)