DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spg7 and ppgn-1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_500191.3	Gene:	ppgn-1 / 177021	WormBaseID:	WBGene00021425	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	716	Identity:	339/716 - (47%)
Similarity:	488/716 - (68%)	Gaps:	29/716 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 PEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMR 163
            |::..|:.|::||:.:||.....:.:.|..:.|..  .|.:.:.:..|..|:...|..:||.: :
Worm    41 PQRRPARPKEESSEAEKSPPKRWEFEISWSSKGHR--ETKSDAKSASEGNENGGGNKGDNDPR-K 102

  Fly   164 SVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMV 228
            .::.|...|| .|.:|......:::|:......:.: :||:||::.:|..|:|..:||.|:.::.
Worm   103 QLMEKMKRWL-AISLFAYGILFILSPKGAAAVTADK-ISWSEFINELLPTGQVYRIIILPEKDVA 165

  Fly   229 TIILHE-GAV-IKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGVPVTYDRQTDTTGRI 289
            .:..:: ||. .:|.|::| ::.:.:....:||.::|..|..||:  :....:.| |:::...:.
Worm   166 YLYCYDTGAKNSRGEKLAS-MYRVGIPSVARFETEVRAAEAALGLPPEHWTQIEY-RRSENVAQW 228

  Fly   290 LMLLLVCALLMSIATRMKSIKSPLSM-DSFNQMGRAKFTLVDP--FDGGR--GVLFRDVAGLSEA 349
            ..::::..||:......:..|...:| |..:.|.:.|||::||  .:|.:  .:.|:||||.|||
Worm   229 FTIIVLGGLLLGGFVLFRKFKGSFNMSDMMSNMTKGKFTIIDPHSVEGKKQLKIKFKDVAGCSEA 293

  Fly   350 KQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMI 414
            |.|::|||||||:|.::.:||||:||||||.|||||||||||||:|.|:.|||:|||||||:|:|
Worm   294 KVEIREFVDYLKNPGRFTKLGAKLPRGALLTGPPGCGKTLLAKALAAESTVPFISMNGSEFVEVI 358

  Fly   415 GGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMG---QGSSGESEQTLNQLLVEMDG 476
            |||||:|:|.||||.:.||||||||||||||||:||.....|   .|.|||.|||||||||||||
Worm   359 GGLGASRIRGLFKEARSRAPCIIYIDEIDAIGRKRSEGAGAGGGFGGGSGEEEQTLNQLLVEMDG 423

  Fly   477 MATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQ 541
            |.:..||::||||||||:|||||||||||||||.|||||:.|||::||.::..:||:..|..:||
Worm   424 MGSGNGVVVLASTNRADVLDKALLRPGRFDRHISIDLPTVLERKDMFELYMRKIKLDHAPQEYSQ 488

  Fly   542 RLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIA 606
            |||.|||||:||||.|||||:|:.||.|....|:.|::|||::|::.|:||||.:|...||:|:|
Worm   489 RLAALTPGFTGADIMNVCNESAIRAASNKCHVVTHKDMEYALDRVLAGSEKRSRSLVEEEREVVA 553

  Fly   607 YHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAEN 671
            |||:|||||||||.::|.||||||:||||.|||||||:|.::||:||:||||:|||.||||.|||
Worm   554 YHEAGHALVGWMLEHTDALLKVTIIPRTSAALGFAQYSPRDKHLFSKDELFDRMCMMLGGRCAEN 618

  Fly   672 LVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMES 736
            |.|.|.|:|||:||:||||.||:|:|.:||:..:||:   ....|||...      ||:|:...|
Worm   619 LKFGRATSGAQDDLQKVTKSAYAQVKLYGMSSIVGPL---SFPNTEGFQI------KPYSKKFAS 674

  Fly   737 MIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESV 801
            ..|.||..:||.|.:.|..::..:.||||.:|:|||::|.|:|:.|.:|||.|.:. .|..::.|
Worm   675 TFDQEATLIVAKANEATTDLIKNNMDKLETIAQALLKREVLNYEDVKKLIGTPKFG-DKHVIDMV 738

  Fly   802 E 802
            |
Worm   739 E 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	26/108 (24%)
		FtsH_fam	333..787	CDD:273520	278/458 (61%)
		AAA	378..513	CDD:278434	103/137 (75%)
		Peptidase_M41	595..785	CDD:279742	101/189 (53%)
ppgn-1	NP_500191.3	FtsH_ext	111..212	CDD:377663	26/103 (25%)
ppgn-1	NP_500191.3	FtsH_fam	277..725	CDD:273520	277/456 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162575
Domainoid	1	1.000	207	1.000	Domainoid score	I1692
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31133
Inparanoid	1	1.050	623	1.000	Inparanoid score	I476
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48979
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0005483
OrthoInspector	1	1.000	-	-		oto18437
orthoMCL	1	0.900	-	-		OOG6_106460
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3185
SonicParanoid	1	1.000	-	-		X4433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.840