Protein Alignment Spg7 and ymel-1

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001366715.1
• Gene: ymel-1 / 176460
• WormBaseID: WBGene00010842
• Length: 723
• Species: Caenorhabditis elegans
• Alignment Length: 789
• Identity: 263/789 - (33%)
• Similarity: 395/789 - (50%)
• Gaps: 115/789 - (14%)

  Fly    38 LLQLSRRQVMQLQAEYKAIVGLIARSLQLTPKEVRLMH--LRSLSS-TAKPPTASDGKTEKHEQP 99
            ||:.||..:.:...:.:|    .|.||.      |:.|  .|..|| |:.|.|.:.......:..
 Worm    18 LLRNSRNGINRKPLDIEA----TAASLS------RVYHQVWRQFSSDTSSPVTINQMNNILRDST 72

  Fly   100 EKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRS 164
            .......|.:.|.....||.......||.........|...:..:|..|:       ...::::|
 Worm    73 LSRRIARKSEISLNYDDAVVRIIPASSSFYIQRRGFRTRKQTFGVGNAGK-------PTQDEVKS 130

  Fly   165 VLTKAVLWLFTIYMFVAFFSLLITPRSER-PEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMV 228
            .||              :||.|:..:.:: .||...  .||::      ..::|:|   |:.:..
 Worm   131 PLT--------------YFSELLAGKKQKTSEGGVE--KWNQY------ESDLKKL---PENQQR 170

  Fly   229 TIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIKDGVPVTYDRQTDTTGRILMLL 293
            |   :....:||      :....|:.|.               |||      ::::|..|..:.|
 Worm   171 T---YTDGFVKG------LLSNGVSGAG---------------KDG------KKSNTLTRFYIFL 205

  Fly   294 LVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFT---LVDPFDGGRGVLFRDVAGLSEAKQEVKE 355
            :.|.....:..|::.....      .|:|...|:   .|:|.|  ..|.|.||.|:.|||.||:|
 Worm   206 VFCIFFGYLTGRIRVRVGD------RQIGSLFFSNPQEVNPED--VQVTFDDVRGMDEAKLEVEE 262

  Fly   356 FVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAA 420
            .|||||.||||.|||.::|:|.||:||||.||||||:|:|.||||||....||||.|::.|.||.
 Worm   263 IVDYLKDPEKYSRLGGRLPKGVLLVGPPGTGKTLLARAIAGEAQVPFFHTAGSEFDEVLVGQGAR 327

  Fly   421 RVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLM 485
            ||||||.:.|.||||||:|||||::|.:|     :.......:.||:||||.||||....||:::
 Worm   328 RVRDLFDKAKARAPCIIFIDEIDSVGSKR-----VSNSIHPYANQTINQLLSEMDGFTRNEGIIV 387

  Fly   486 LASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGF 550
            :|:|||.|.||||||||||||..:.:..|.||.|.:||..:||  |:........:.||:.:.||
 Worm   388 IAATNRVDDLDKALLRPGRFDVRVTVPKPDLAGRVDIFNFYLS--KIVHSGGIDPKVLAKGSTGF 450

  Fly   551 SGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAE-RKVIAYHESGHAL 614
            :||||.|:.|:|||.||.:..:||:...|:.|.:|::.|..:....:...| .:..||||:||.|
 Worm   451 TGADIENMVNQAALKAATDNAVEVTMAYLDEARDRVLMGPARTGGRIPDEEANRNTAYHEAGHTL 515

  Fly   615 VGWMLPNSDILLKVTIVPRTSLALGFAQYTP-SEQHLYSKEELFDKMCMALGGRAAENLVF--NR 676
            |.....::..|.||||:|| ..:||.....| .:.:..:|.::...:.:.:|||.||.|:|  ::
 Worm   516 VSLYTKDATPLHKVTIIPR-GQSLGHTAMLPEKDSYQLTKAQMLATLDVMMGGRVAEELIFGDDK 579

  Fly   677 ITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMES--MID 739
            :||||.:||.|.|::|...:|.|||:|.:|   :||....:...|:    .|....|.::  :||
 Worm   580 VTTGAADDLSKATQLAVQMVKVFGMSDKVG---LRDFTAQDNESAL----VKVSDLAPQTAELID 637

  Fly   740 NEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIG------PPPYDLGKRQV 798
            .|...|:..:|:..:.||.|.:.:.:.|||||||.|||..|:|.::|.      |.|..: |:..
 Worm   638 AEINRVLQESYKRAKVILETKKKEHQLLAEALLEYETLSADEVKRVISGQKIKRPTPAAV-KKSN 701

  Fly   799 ESVEFEQSL 807
            |:...:.||
 Worm   702 ETKRNQPSL 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	229/625 (37%)
ymel-1	NP_001366715.1	HflB	170..686	CDD:440233	219/568 (39%)