Protein Alignment Spg7 and spg-7

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_491165.2
• Gene: spg-7 / 171915
• WormBaseID: WBGene00004978
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 814
• Identity: 315/814 - (38%)
• Similarity: 446/814 - (54%)
• Gaps: 101/814 - (12%)

  Fly    62 RSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAV-------- 118
            |..:.|||::|    .|:.|..|...:........      ||.||||.|..|:..|
 Worm     3 RLYRKTPKQLR----NSVESCFKSVNSRQFSVSSF------SAVAKDDKSVLKQQEVLHLLAKDQ 57

  Fly   119 -----------------AAEDGD------KSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDE 160
                             |::..|      |.:....:|::|:.....:.|..||| |...|:...
 Worm    58 RFEERFFNQVQQTIRYFASKPNDLKKFFRKEASTDNKESSSSSDKKDSKGNKGED-NNPFNQFPG 121

  Fly   161 KMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDM 225
            ..:.:.....: |..:|.|:.:             .|.|.:||.||....|..|.|:.|.: .|.
 Worm   122 GWQQIAVSVGI-LLALYAFMDY-------------QSYREISWKEFYSDFLEAGLVERLEV-VDK 171

  Fly   226 EMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRL--GIKDGVPVTYDRQTDTTGR 288
            ..|.|:...|      |.:....:..:...:.||..|...:..|  .....:||.|..:.:....
 Worm   172 RWVRIVSSSG------KYAGQTCYFNIGSVDSFERSLGAAQHHLQYDADRQIPVLYKSEFNFKRE 230

  Fly   289 ILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------VLF 340
            |..|:.|...|:......:.:|..   .:....|||....:....||.|             |.|
 Worm   231 IPNLISVAFPLLFGYYIYRMLKGG---GAAGGAGRAGGGGLGGMFGGFGQSTARVINREDIKVKF 292

  Fly   341 RDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSM 405
            .||||..|||.|:.|||::||:|::|:.||||:|:||:|.||||.||||||||.|.||.|||:::
 Worm   293 ADVAGCEEAKIEIMEFVNFLKNPQQYKDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITV 357

  Fly   406 NGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQL 470
            :||||:||..|:|.|||||:|...:|.:|||::||||||:||:|.|  ..|.|...|.|.|||||
 Worm   358 SGSEFLEMFVGVGPARVRDMFSMARKNSPCILFIDEIDAVGRKRGG--KGGMGGHSEQENTLNQL 420

  Fly   471 LVEMDGMATKE-GVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLES 534
            ||||||..|.| .|:::|:|||.||||.||||||||||.|.:.:|.:..|..||..||..::...
 Worm   421 LVEMDGFTTDESSVIVIAATNRVDILDSALLRPGRFDRQIYVPVPDIKGRASIFRVHLGPLRTSL 485

  Fly   535 PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
            ..|..|::||..|||||||||:||||||||.|||:...|:|:|:.|.|:||:|.|.||::..|..
 Worm   486 DKTVLSRKLAAHTPGFSGADISNVCNEAALIAARDANHEISNKHFEQAIERVVAGMEKKTQVLQK 550

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMAL 664
            .|:|.:||||:|||:.||.|.::|.||||:|:|| ...||:|||.|.||:||||::|.|:|||.|
 Worm   551 EEKKTVAYHEAGHAIAGWFLQHADPLLKVSIIPR-GKGLGYAQYLPKEQYLYSKDQLLDRMCMTL 614

  Fly   665 GGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKP 729
            |||.||.:.|.|||||||:||:|||::||||:.||||::.:||:    :.||...|.|..  .||
 Worm   615 GGRVAEEIFFGRITTGAQDDLQKVTQMAYSQVVKFGMSEKVGPL----SFETPAPGEMAF--DKP 673

  Fly   730 FSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPY--- 791
            :|.|...:||.|.|.:|.:|.:.|..:|...|..:|::|..|||||.|:.:.:::|:|..|:
 Worm   674 YSEATAQLIDQEVRDLVMNALRRTRDLLLEKRSDIERVALRLLEKEILNREDMIELVGKRPFVEK 738

  Fly   792 DLGKRQV-------ESVEFEQSLKNLSTDTDATK 818
            :..:..|       |:||..:.|:|.:.:::..|
 Worm   739 NTYEEMVSGTGGLDENVELPKGLENWNKESEKKK 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	276/625 (44%)
spg-7	NP_491165.2	HflB	126..732	CDD:440233	278/638 (44%)