DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and spg-7

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_491165.2	Gene:	spg-7 / 171915	WormBaseID:	WBGene00004978	Length:	782	Species:	Caenorhabditis elegans

Alignment Length:	814	Identity:	315/814 - (38%)
Similarity:	446/814 - (54%)	Gaps:	101/814 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RSLQLTPKEVRLMHLRSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAV-------- 118
            |..:.|||::|    .|:.|..|...:........      ||.||||.|..|:..|
Worm     3 RLYRKTPKQLR----NSVESCFKSVNSRQFSVSSF------SAVAKDDKSVLKQQEVLHLLAKDQ 57

  Fly   119 -----------------AAEDGD------KSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDE 160
                             |::..|      |.:....:|::|:.....:.|..||| |...|:...
Worm    58 RFEERFFNQVQQTIRYFASKPNDLKKFFRKEASTDNKESSSSSDKKDSKGNKGED-NNPFNQFPG 121

  Fly   161 KMRSVLTKAVLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDM 225
            ..:.:.....: |..:|.|:.:             .|.|.:||.||....|..|.|:.|.: .|.
Worm   122 GWQQIAVSVGI-LLALYAFMDY-------------QSYREISWKEFYSDFLEAGLVERLEV-VDK 171

  Fly   226 EMVTIILHEGAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRL--GIKDGVPVTYDRQTDTTGR 288
            ..|.|:...|      |.:....:..:...:.||..|...:..|  .....:||.|..:.:....
Worm   172 RWVRIVSSSG------KYAGQTCYFNIGSVDSFERSLGAAQHHLQYDADRQIPVLYKSEFNFKRE 230

  Fly   289 ILMLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------VLF 340
            |..|:.|...|:......:.:|..   .:....|||....:....||.|             |.|
Worm   231 IPNLISVAFPLLFGYYIYRMLKGG---GAAGGAGRAGGGGLGGMFGGFGQSTARVINREDIKVKF 292

  Fly   341 RDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSM 405
            .||||..|||.|:.|||::||:|::|:.||||:|:||:|.||||.||||||||.|.||.|||:::
Worm   293 ADVAGCEEAKIEIMEFVNFLKNPQQYKDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITV 357

  Fly   406 NGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQL 470
            :||||:||..|:|.|||||:|...:|.:|||::||||||:||:|.|  ..|.|...|.|.|||||
Worm   358 SGSEFLEMFVGVGPARVRDMFSMARKNSPCILFIDEIDAVGRKRGG--KGGMGGHSEQENTLNQL 420

  Fly   471 LVEMDGMATKE-GVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLES 534
            ||||||..|.| .|:::|:|||.||||.||||||||||.|.:.:|.:..|..||..||..::...
Worm   421 LVEMDGFTTDESSVIVIAATNRVDILDSALLRPGRFDRQIYVPVPDIKGRASIFRVHLGPLRTSL 485

  Fly   535 PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
            ..|..|::||..|||||||||:||||||||.|||:...|:|:|:.|.|:||:|.|.||::..|..
Worm   486 DKTVLSRKLAAHTPGFSGADISNVCNEAALIAARDANHEISNKHFEQAIERVVAGMEKKTQVLQK 550

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMAL 664
            .|:|.:||||:|||:.||.|.::|.||||:|:|| ...||:|||.|.||:||||::|.|:|||.|
Worm   551 EEKKTVAYHEAGHAIAGWFLQHADPLLKVSIIPR-GKGLGYAQYLPKEQYLYSKDQLLDRMCMTL 614

  Fly   665 GGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKP 729
            |||.||.:.|.|||||||:||:|||::||||:.||||::.:||:    :.||...|.|..  .||
Worm   615 GGRVAEEIFFGRITTGAQDDLQKVTQMAYSQVVKFGMSEKVGPL----SFETPAPGEMAF--DKP 673

  Fly   730 FSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPY--- 791
            :|.|...:||.|.|.:|.:|.:.|..:|...|..:|::|..|||||.|:.:.:::|:|..|:
Worm   674 YSEATAQLIDQEVRDLVMNALRRTRDLLLEKRSDIERVALRLLEKEILNREDMIELVGKRPFVEK 738

  Fly   792 DLGKRQV-------ESVEFEQSLKNLSTDTDATK 818
            :..:..|       |:||..:.|:|.:.:::..|
Worm   739 NTYEEMVSGTGGLDENVELPKGLENWNKESEKKK 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	22/106 (21%)
		FtsH_fam	333..787	CDD:273520	245/467 (52%)
		AAA	378..513	CDD:278434	84/135 (62%)
		Peptidase_M41	595..785	CDD:279742	92/189 (49%)
spg-7	NP_491165.2	FtsH_ext	123..218	CDD:310823	22/115 (19%)
spg-7	NP_491165.2	TIP49	278..731	CDD:332389	242/461 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820