Protein Alignment Spg7 and YME1L

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_061509678.1
• Gene: YME1L / 1279395
• VectorBaseID: AGAMI1_003770
• Length: 764
• Species: Anopheles gambiae
• Alignment Length: 813
• Identity: 264/813 - (32%)
• Similarity: 394/813 - (48%)
• Gaps: 167/813 - (20%)

  Fly    73 LMHLRSLSSTAKPPTASDGKTEKH---------EQPEKG----SAKAKDDSSKEKKSAVAA--ED 122
            |.||..::     |..|....:||         :||::|    |..|:.|.....|.::..  .|
Mosquito    12 LFHLSQIT-----PRHSSIAFKKHHRHHQHHQQQQPQQGREAVSQLAQQDFVPRLKQSLVTFYTD 71

  Fly   123 GDKSSRAAGEEAASTPTSSSTIGEPGE-----------DPNKNSNENDEKMRSVLTKAVLWLFTI 176
            ..:||      ...:|..::....|.|           :.|...:.:..::...:.::..|
Mosquito    72 AFRSS------VEPSPAGAAPAQVPSEELYRLKLPRRLERNLLKHFSQVELLGSIKESTPW---- 126

  Fly   177 YMFVAFFSLLITPRSE--RPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTI--ILHEGAV 237
                   ||.:||:.:  :.:.....||::         ||..:.|:|..:...|.  .:.:...
Mosquito   127 -------SLNVTPKVKHGKCDAIAETVSFS---------GESVQKIVRSLLAQPTSWNTVQQRGF 175

  Fly   238 IKGRKVSSTI-----FHMAVADA---------NKFEEKLRDVEKRLGIKDGVPVTYDRQT---DT 285
            ...|.:|:.:     .:..:.||         :|::                ||.|..||   ..
Mosquito   176 KTVRSISAELKRNPALYTRMKDALGNPAPPISHKYD----------------PVAYSAQTIAPSA 224

  Fly   286 TGRILMLLLVCALLMSIATRMK----------SIKSPLSMDSFNQMGRA----KF---------- 326
            .|..|..||....::|...|.:          :..:|   |..|:.|:|    ||
Mosquito   225 HGEPLNKLLADDPMLSDEQRQRLKIAFAEGYLTASNP---DQQNRSGKAMKYLKFFQQLLIIVVF 286

  Fly   327 ------------------------TLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQ 367
                                    ..|||.|  ..|.|.||.|..|||||:||.|::||:|.|:.
Mosquito   287 IGIFISMFASPNGSVFSRIQIGNQVEVDPED--ITVTFEDVKGCDEAKQELKEVVEFLKNPGKFS 349

  Fly   368 RLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKR 432
            .||.|:|:|.||:||||.||||||:|||.||.|||....|.||.|::.|.||.|||||||..|:|
Mosquito   350 NLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKER 414

  Fly   433 APCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDK 497
            |||:|:|||||::|.:|  |.|:   ....:.||:||||.||||....|||::|.:|||.|.||:
Mosquito   415 APCVIFIDEIDSVGAKR--TNSV---LHPYANQTINQLLSEMDGFQQNEGVIVLGATNRRDDLDQ 474

  Fly   498 ALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEA 562
            |||||||||..:::..|....||||...:|.  |:.|......| |||.|.||:||||.|:.|:|
Mosquito   475 ALLRPGRFDVEVVVPTPDFTGRKEILTYYLG--KILSREINIDQ-LARGTTGFTGADIENMVNQA 536

  Fly   563 ALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLK 627
            ||.||.:....||.|:||.|.::::.|.|::|........|:.||||.|||:|.:....|..|.|
Mosquito   537 ALRAAIDGAETVSMKHLENARDKVLMGPERKSRLPDEEANKITAYHEGGHAIVAYYTKESHPLHK 601

  Fly   628 VTIVPRTSLALGFAQYTP-SEQHLYSKEELFDKMCMALGGRAAENLVF--NRITTGAQNDLEKVT 689
            |||:|| ..:||...|.| .|::..:|::|...|...:||||||.|:|  ::||:||.:||::.|
Mosquito   602 VTIMPR-GPSLGHTAYIPEKERYHVTKQQLLAMMDTMMGGRAAEELIFGADKITSGASSDLKQAT 665

  Fly   690 KIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTE 754
            .||...:|::||::.:|   :|..:     |..|.|..:..|.:....:|||.:.::..:|:..:
Mosquito   666 SIAAHMVKEWGMSERVG---LRTIE-----GPKGFGQNEVLSPSTIESVDNEIKKLLNESYERAK 722

  Fly   755 GILTTHRDKLEKLAEALLEKETLDYDQVVQLIG 787
            .||..|..:.:.||||||:.||||.:.:..::|
Mosquito   723 AILKQHAKEHKALAEALLKYETLDAEDIKAIMG 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	242/682 (35%)
YME1L	XP_061509678.1	None