Protein Alignment Spg7 and Afg3l1

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_473411.2
• Gene: Afg3l1 / 114896
• MGIID: 1928277
• Length: 789
• Species: Mus musculus
• Alignment Length: 793
• Identity: 327/793 - (41%)
• Similarity: 442/793 - (55%)
• Gaps: 114/793 - (14%)

  Fly    57 VGLIARSLQLTPKEVRLMHLRSLSST--AKPPTASDGKTEKHEQPEKGSAKAKDDSS----KEKK 115
            :|..::.|.|..|      |.|.|..  :|||..    .||..:.:|....|...:|    ||.|
Mouse    49 LGRCSQQLALQGK------LTSFSPRLYSKPPRG----FEKFFKNKKNRKSASPGNSVPPKKEPK 103

  Fly   116 SAVAAEDGDKSSRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRSVLTKAVLWLFTIYMFV 180
            :  |...||..:|  |.:....|.....  :.||.|     .:|:..||:   |||.......|:
Mouse   104 N--AGPGGDGGNR--GGKGDDFPWWKRM--QKGEFP-----WDDKDFRSL---AVLGAGVAAGFL 154

  Fly   181 AFFSLLITPRSERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSS 245
            .|:.        |..|  :.::|..||.:.||.|.|..|.: .:.:.|.:|...|.      .|.
Mouse   155 YFYF--------RDPG--KEITWKHFVQYYLARGLVDRLEV-VNKQFVRVIPVPGT------TSE 202

  Fly   246 TIFHMAVADANKFEEKLRDVEKRLGIK--DGVPVTYDRQTDTTGRILMLLLVCALLMSI---ATR 305
            ......:...:.||..|...:..|||:  :...|.|..::|  |..|..|:...:|:||   |.|
Mouse   203 RFVWFNIGSVDTFERNLESAQWELGIEPTNQAAVVYTTESD--GSFLRSLVPTLVLVSILLYAMR 265

  Fly   306 MKSIKSPLSMDSFNQMGRAKFTLVDPFDGGRG-------------------VLFRDVAGLSEAKQ 351
                :.|        ||..:        ||||                   |.|.||||..|||.
Mouse   266 ----RGP--------MGTGR--------GGRGGGLFSVGETTAKILKNNIDVRFADVAGCEEAKL 310

  Fly   352 EVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGG 416
            |:.|||::||:|::||.||||:|:||:|.||||.||||||||.|.||.|||:::|||||:||..|
Mouse   311 EIMEFVNFLKNPKQYQDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVG 375

  Fly   417 LGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSG---ESEQTLNQLLVEMDGMA 478
            :|.|||||:|...:|.||||::|||||||||:|      |:|..|   |.|.||||:||||||..
Mouse   376 VGPARVRDMFAMARKHAPCILFIDEIDAIGRKR------GRGHLGGQSEQENTLNQMLVEMDGFN 434

  Fly   479 TKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLES--PPTTFSQ 541
            :...|::||.|||.||||.||.|||||||.|.|..|.:..|..||:.||..:||:.  .....|:
Mouse   435 SSTNVVVLAGTNRPDILDPALTRPGRFDRQIYIGPPDIKGRSSIFKVHLRPLKLDGSLSKDALSR 499

  Fly   542 RLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSLAERKVIA 606
            :||.|||||:||||:||||||||.|||:....|..::.|.|:||::||.||::..|..:|:..:|
Mouse   500 KLAALTPGFTGADISNVCNEAALIAARHLSPSVQERHFEQAIERVIGGLEKKTQVLQPSEKTTVA 564

  Fly   607 YHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKEELFDKMCMALGGRAAEN 671
            |||:|||:|||.|.::|.||||:|:|| ...||:|||.|.||.||::|:|||:|||.||||.||.
Mouse   565 YHEAGHAVVGWFLEHADPLLKVSIIPR-GKGLGYAQYLPREQFLYTREQLFDRMCMMLGGRVAEQ 628

  Fly   672 LVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGGKKPFSRAMES 736
            |.|.:||||||:||.|||:.||:||.:|||::.||.:   ..|....|..|   .:||:|.|...
Mouse   629 LFFGQITTGAQDDLRKVTQSAYAQIVQFGMSEKLGQV---SFDFPRQGETM---VEKPYSEATAQ 687

  Fly   737 MIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQVVQLIGPPPYDLGKRQVESV 801
            :||.|.|.:|.|||..|..:||..|:::||:...|||||.|:...:::|:||.|: ..|...|
Mouse   688 LIDEEVRCLVRSAYNRTLELLTQCREQVEKVGRRLLEKEVLEKADMIELLGPRPF-AEKSTYE-- 749

  Fly   802 EFEQSLKNLSTDT 814
            ||.:...:|..||
Mouse   750 EFVEGTGSLEEDT 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	284/638 (45%)
Afg3l1	NP_473411.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..121		11/43 (26%)
		HflB	149..739	CDD:440233	284/641 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	749..789		6/16 (38%)