DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spg7 and AFG3L2

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_006787.2	Gene:	AFG3L2 / 10939	HGNCID:	315	Length:	797	Species:	Homo sapiens

Alignment Length:	748	Identity:	320/748 - (42%)
Similarity:	442/748 - (59%)	Gaps:	76/748 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 QPEKGSAKAKDDSSKEKKSAVAAEDGDKSSRAAGEEAASTP--TSSSTIGEPGEDPNKNSNENDE 160
            :|.||..|...:....||::...|       ..||:..|.|  |:.|:.|..|....:...::|.
Human    68 RPPKGFEKYFPNGKNGKKASEPKE-------VMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDS 125

  Fly   161 KMRSVLTKA------------VLWLFTIYMFVAFFSLLITPRSERPEGSTRYVSWNEFVHHMLAV 213
            ...|...|.            .||....:..|.|:.||        :.|.|.::|.:||::.|:.
Human   126 HWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLL--------KRSGREITWKDFVNNYLSK 182

  Fly   214 GEVKELIIRPDMEMVTIILHEGAV-IKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGI--KDGV 275
            |.|..|.: .:...|.:....|.. :.|:.|   .|::...|.  ||..|..:::.|||  ::.|
Human   183 GVVDRLEV-VNKRFVRVTFTPGKTPVDGQYV---WFNIGSVDT--FERNLETLQQELGIEGENRV 241

  Fly   276 PVTYDRQTDTTGRILML---LLVCALLMSIATRMKSI-KSPLSMDSFNQMGR--AKFTLVDPFDG 334
            ||.|..::|.:..:.||   |::..||.:|......| ::...|.....:|.  || .|.|..|
Human   242 PVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAK-VLKDEID- 304

  Fly   335 GRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQ 399
               |.|:||||..|||.|:.|||::||:|::||.||||:|:||:|.||||.||||||||.|.||.
Human   305 ---VKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 366

  Fly   400 VPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSG--- 461
            |||::::||||:||..|:|.|||||||...:|.||||::||||||:||:|      |:|:.|
Human   367 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKR------GRGNFGGQS 425

  Fly   462 ESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKH 526
            |.|.|||||||||||..|...|::||.|||.||||.||||||||||.|.|..|.:..|..||:.|
Human   426 EQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVH 490

  Fly   527 LSSVKLES--PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGG 589
            |..:||:|  .....:::||.|||||||||:|||||||||.|||:....::.|:.|.|:||::||
Human   491 LRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGG 555

  Fly   590 TEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTPSEQHLYSKE 654
            .||::..|...|:|.:||||:|||:.||.|.::|.||||:|:|| ...||:|||.|.||:||:||
Human   556 LEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPR-GKGLGYAQYLPKEQYLYTKE 619

  Fly   655 ELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPI---YVRDADET 716
            :|.|:|||.||||.:|.:.|.|||||||:||.|||:.||:||.:||||:.:|.|   ..|..|..
Human   620 QLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMV 684

  Fly   717 EGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQ 781
            .         :||:|.|...:||:|.|.::..||:.|..:||..:..:||:|..|||||.||.:.
Human   685 L---------EKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKND 740

  Fly   782 VVQLIGPPPYDLGKRQVESVEFEQSLKNLSTDT 814
            :|:|:||.|: ..|...|  ||.:...:|..||
Human   741 MVELLGPRPF-AEKSTYE--EFVEGTGSLDEDT 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011	27/107 (25%)
		FtsH_fam	333..787	CDD:273520	247/461 (54%)
		AAA	378..513	CDD:278434	87/137 (64%)
		Peptidase_M41	595..785	CDD:279742	92/192 (48%)
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..126		12/56 (21%)
		FtsH_ext	146..242	CDD:310823	27/109 (25%)
		TIP49	253..746	CDD:332389	260/513 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..797		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820