DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spg7 and YME1L1

DIOPT Version :9

Sequence 1:	NP_570017.1	Gene:	Spg7 / 31253	FlyBaseID:	FBgn0024992	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens

Alignment Length:	511	Identity:	197/511 - (38%)
Similarity:	304/511 - (59%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 RQTDTTGRILMLLLVCALLMSIATRMKS------IKSPLSMDSFNQMGRAKFTLVDPFDGGRGVL 339
            ::|:.:.|...|:|...||..|...:|:      .::...:||          .|||.. .:.|.
Human   284 QKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDS----------AVDPVQ-MKNVT 337

  Fly   340 FRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQVPFLS 404
            |..|.|:.|||||::|.|::||:|:|:..||.|:|:|.||:||||.||||||:|||.||.|||..
Human   338 FEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYY 402

  Fly   405 MNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESEQTLNQ 469
            .:||||.||..|:||:|:|:||:|.|..|||:|:|||:|::|.:|     :.......|.||:||
Human   403 ASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR-----IESPMHPYSRQTINQ 462

  Fly   470 LLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHLSSVKLES 534
            ||.||||....|||:::.:||..:.||.||:||||||..:.:..|.:..|.||.:.:|:.:|.:.
Human   463 LLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQ 527

  Fly   535 PPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLVGGTEKRSHALSL 599
              :...:.:||.|.|||||::.|:.|:|||.||.:.:..|:.|.||::.::::.|.|:||..:..
Human   528 --SVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN 590

  Fly   600 AERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGFAQYTP-SEQHLYSKEELFDKMCMA 663
            ..:.:.||||||||::.:...::..:.|.||:|| ...||.....| :::...::.:|..:|.::
Human   591 KNKTITAYHESGHAIIAYYTKDAMPINKATIMPR-GPTLGHVSLLPENDRWNETRAQLLAQMDVS 654

  Fly   664 LGGRAAENLVF--NRITTGAQNDLEKVTKIAYSQIKKFGMNDTLGPIYVRDADETEGGGAMGSGG 726
            :|||.||.|:|  :.|||||.:|.:..||||...:.||||::.||.:...|.            |
Human   655 MGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDT------------G 707

  Fly   727 KKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEALLEKETLDYDQV 782
            |  .|...:|.|:.|.|.::..:|:..:.||.||..:.:.||||||..||||..::
Human   708 K--LSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEI 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	FtsH_ext	171..276	CDD:284011
		FtsH_fam	333..787	CDD:273520	184/453 (41%)
		AAA	378..513	CDD:278434	71/134 (53%)
		Peptidase_M41	595..785	CDD:279742	64/191 (34%)
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	35/64 (55%)
		FtsH_fam	333..766	CDD:273520	184/451 (41%)
		AAA	375..506	CDD:278434	71/135 (53%)
		Peptidase_M41	586..764	CDD:279742	64/191 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820