Protein Alignment Spg7 and spg7

DIOPT Version :10

• Sequence 1: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_002933705.2
• Gene: spg7 / 100485977
• XenbaseID: XB-GENE-6034036
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 805
• Identity: 376/805 - (46%)
• Similarity: 517/805 - (64%)
• Gaps: 103/805 - (12%)

  Fly    16 GSQLIQLRSATGQPPRIG-----RELSLLQLSRRQVMQLQAEYKAIVGLIARSLQLTP-----KE 70
            |..|:.||..     |:|     |::...:.|..:::|         .|:.|:  |||     :|
 Frog     2 GILLLALRGL-----RLGSAGCWRKVPRAECSESRILQ---------NLLCRN--LTPGSHGMRE 50

  Fly    71 VRL-MHL--------RSLSSTAKPPTASDGKTEKHEQPEKGSAKAKDDSSKEKKSAVAAEDGDKS 126
            ..: .||        |.|.......|:..|..|...:..||....:|:..|:::     |..|:.
 Frog    51 YLIKRHLIQDPLRIWRILGGINYFSTSGRGNKENQNEGSKGKTPHEDEEEKKRR-----EREDQM 110

  Fly   127 SRAAGEEAASTPTSSSTIGEPGEDPNKNSNENDEKMRSVLTKAVLWLFTIYMFVAFFSLLITPRS 191
            .|                               |::|           |:::.....|||.:..|
 Frog   111 YR-------------------------------ERLR-----------TLFIIAVIMSLLNSLSS 133

  Fly   192 ERPEGSTRYVSWNEFVHHMLAVGEVKELIIRPDMEMVTIILHEGAVIKGRKVSSTIFHMAVADAN 256
                 |...:|||:||:.|||.|||..:.:.|:.::|.|.|:.|||:.||...:.::.|.||:.:
 Frog   134 -----SGGNISWNDFVNEMLAKGEVMRVQVVPESDIVEIYLYPGAVVFGRPRLALMYRMQVANID 193

  Fly   257 KFEEKLRDVEK--RLGIKDGVPVTYDRQTDTTGRILMLLLVCALLMSIATRMKSIKSPL----SM 315
            |||||||..|:  ::.:||.:||:|.| |...|..|..|.:.|:.::|...:..:....    :.
 Frog   194 KFEEKLRAAEEELKINVKDRIPVSYKR-TGFFGNALYALGMAAVGVAILWYIFRLAGMAGREGAF 257

  Fly   316 DSFNQMGRAKFTLVDPFDGGRGVLFRDVAGLSEAKQEVKEFVDYLKSPEKYQRLGAKVPRGALLL 380
            .:|||:..|:||:||. ..|:|:.|:||||:.|||.||||||||||||::|.:||||||:|||||
 Frog   258 SAFNQLKMARFTIVDG-KSGKGISFKDVAGMHEAKLEVKEFVDYLKSPDRYLQLGAKVPKGALLL 321

  Fly   381 GPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAI 445
            |||||||||||||||||||||||:|.||||:|:||||||||||.||||.:.|||||:|||||||:
 Frog   322 GPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEVIGGLGAARVRSLFKEARTRAPCIVYIDEIDAV 386

  Fly   446 GRQRSGTESMGQGSSGESEQTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHIL 510
            |::||  .:|...|:.|.||||||||||||||.|.:.|::|||||||||||.||:||||.||||.
 Frog   387 GKKRS--TNMSSFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDNALMRPGRLDRHIF 449

  Fly   511 IDLPTLAERKEIFEKHLSSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVS 575
            ||||||.||:||||:||.|:||..|.:.:|||||.||||||||||||:||||||||||.....:.
 Frog   450 IDLPTLQERREIFEQHLKSLKLTQPGSFYSQRLAELTPGFSGADIANICNEAALHAAREGYQSID 514

  Fly   576 SKNLEYAVERLVGGTEKRSHALSLAERKVIAYHESGHALVGWMLPNSDILLKVTIVPRTSLALGF 640
            :.|.||||||::.||.|:|..:|..||:|:|:||||||||||:|.:::.::||:|.|||:.||||
 Frog   515 TFNFEYAVERVIAGTAKKSKIMSKEERRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGF 579

  Fly   641 AQYTPSEQHLYSKEELFDKMCMALGGRAAENLVFNRITTGAQNDLEKVTKIAYSQIKKFGMNDTL 705
            ||..|.||:||:||:|.::||||||||.:|.:.||::|||||:||.|||:|||:.:|::||..::
 Frog   580 AQILPREQYLYTKEQLLERMCMALGGRVSEAITFNKVTTGAQDDLRKVTRIAYAMVKQYGMVPSI 644

  Fly   706 GPIYVRDADETEGGGAMGSGGKKPFSRAMESMIDNEARHVVASAYQTTEGILTTHRDKLEKLAEA 770
            |.:...|::.|.|      .|::|||:.::.|:|.||:.:|::||:.||.:|..:||||..|..|
 Frog   645 GQVSFPDSESTPG------IGRRPFSQGLQEMMDREAQLLVSTAYRRTEKLLLDNRDKLILLTNA 703

  Fly   771 LLEKETLDYDQVVQLIGPPPYDLGK 795
            |||:|.::||.:..||||||:...|
 Frog   704 LLEREVINYDDIEHLIGPPPFGAKK 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spg7	NP_570017.1	HflB	178..788	CDD:440233	339/615 (55%)
spg7	XP_002933705.2	HflB	118..721	CDD:440233	339/617 (55%)