DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment per and PER3

DIOPT Version :10

Sequence 1:NP_525056.2 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_001276791.1 Gene:PER3 / 8863 HGNCID:8847 Length:1210 Species:Homo sapiens


Alignment Length:1289 Identity:269/1289 - (20%)
Similarity:432/1289 - (33%) Gaps:344/1289 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 EKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQ 168
            |.|.|...|..::.:..|..::...|.|.:.:..:....|:::....||.....|:.:.|...::
Human     5 EAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFPSE 69

  Fly   169 SFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGE 233
            ....||.|.      ::.......|:...:|...:. .:....|....||..:...|....:...
Human    70 RRNKPSTLD------ALNYALRCVHSVQANSEFFQI-LSQNGAPQADVSMYSLEELATIASEHTS 127

  Fly   234 RVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAE 298
            : ..|:|..|.|...|.:::.:.....:|...:|:.....|:|.:..:|...|.:.        .
Human   128 K-NTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAH--------T 183

  Fly   299 SRGSVP---------------KDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAP 348
            :|..:|               ...|..||    |.||.:.........|....|:.:.:.....|
Human   184 ARAQLPFWNNWTQRAAARYECAPVKPFFC----RIRGGEDRKQEKCHSPFRIIPYLIHVHHPAQP 244

  Fly   349 E-EARPDNYMVSNGTNMLLVICAT---PIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAV 409
            | |:.|              .|.|   .|.|.|:.|...::::.  |...||...:...||..||
Human   245 ELESEP--------------CCLTVVEKIHSGYEAPRIPVNKRI--FTTTHTPGCVFLEVDEKAV 293

  Fly   410 SALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAG-ASFCSKPYRFLIQNGCYVLLET 473
            ..||||||||||.||:.:.|.||.|:|...::.|:|   .|| ..|...|.||..|||.|::|::
Human   294 PLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK---YAGHPPFEHSPIRFCTQNGDYIILDS 355

  Fly   474 EWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETV 538
            .|:|||||||||:.|::|.|:|...|...:||    ..|:|...:.....|.::|.|.|.|.:.|
Human   356 SWSSFVNPWSRKISFIIGRHKVRTSPLNEDVF----ATKIKKMNDNDKDITELQEQIYKLLLQPV 416

  Fly   539 S----------RPSDTVKQEVSRRCQALASFMET---LMDEVSRADLKLELPHEN---------- 580
            .          ..|.:.:|.||     :||..|.   .::|.....:.|:..:.:          
Human   417 HVSVSSGYGSLGSSGSQEQLVS-----IASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQ 476

  Fly   581 ----ELTVSERDSVMLGEISPH------------------HDYYDSKS----------STETPPS 613
                .:|.|....|......|:                  |....:.|          :.|..||
Human   477 LYIESMTKSSFKPVTGTRTEPNGGGESANGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPS 541

  Fly   614 YNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTT 678
            |.|:|..::::|:..|..:             |..:..|:|..:...|...|......:......
Human   542 YQQINCIDSVIRYLKSYNI-------------PALKRKCISCTNTTSSSSEEDKQNHKADDVQAL 593

  Fly   679 ASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSG 743
            .:.:.:.::..:.:. |.|....||.|......|..                             
Human   594 QAGLQIPAIPKSEMP-TNGRSIDTGGGAPQILSTAM----------------------------- 628

  Fly   744 TGTGTASSSKGGSAAI----PPVT-----------------------------LTESLLNKHNDE 775
            ...|:..|..|.|:.|    ||.|                             ||.::|:.|..:
Human   629 LSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGLTAAVLSAHTQK 693

  Fly   776 MEKFMLKKHRESRGRTGEKSKKSANDTLKMLE--YSGPGHGIKRGGSHSWEGEANKPKQQLTLGT 838
            .|:..:.|.||                 |:|.  ||          |:..:...:|.|.....| 
Human   694 EEQNYVDKFRE-----------------KILSSPYS----------SYLQQESRSKAKYSYFQG- 730

  Fly   839 DAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAA 903
            |:......|||...|......                 .||...:::|.||:....|....|...
Human   731 DSTSKQTRSAGCRKGKHKRKK-----------------LPEPPDSSSSNTGSGPRRGAHQNAQPC 778

  Fly   904 AAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGL-------- 960
            ..:.|||...||...|.:....:|...|.|.|.:   |...|.....|....:..||        
Human   779 CPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPL---PAATSPGREYAAPGTAPEGLHGLPLSEG 840

  Fly   961 ------FPTFYYIPASLT------PTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYM 1013
                  || |.|:...:|      |..|..||.....|..|.|.....|...::|         |
Human   841 LQPYPAFP-FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSA---------M 895

  Fly  1014 AGVMYPHPSLFYT-------------HPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNK 1065
            :..:.|.||:...             ||...:.::.       |...|.|| .|.|..|:|. ::
Human   896 SPTLDPPPSVTSQRREEEKWEAQSEGHPFITSRSSS-------PLQLNLLQ-EEMPRPSESP-DQ 951

  Fly  1066 SVYTTTPASMTKKVPGAFHSVTTPAQV----------QRPSSQSASV----------KTEPGSSA 1110
            ....|.|.:..:.|.|...|.::||..          :.||..:||.          .:.|.:||
Human   952 MRRNTCPQTEYQCVTGNNGSESSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASA 1016

  Fly  1111 --AVSDPCKK-EVPDSSPI-----PSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSF-- 1165
              ..|.|.|. ..|.:|.:     ||....:.:....|:.:|.:.......:..|...|.|.:  
Human  1017 LSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLT 1081

  Fly  1166 SSFYSSFIKTTDGSESP--------PDTEKDPKHRKLKSMSTSESKIMEH--PE 1209
            ||.|||.| :.:|.:|.        |:..::|..|.::  .|.|..:|.:  ||
Human  1082 SSVYSSKI-SQNGQQSQDVQKKETFPNVAEEPIWRMIR--QTPERILMTYQVPE 1132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
perNP_525056.2 PAS 238..333 CDD:395786 19/109 (17%)
PAS 388..495 CDD:238075 50/107 (47%)
PER3NP_001276791.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 8/44 (18%)
Nuclear export signal 1. /evidence=ECO:0000250 55..64 1/8 (13%)
PAS 285..377 CDD:238075 47/94 (50%)
Nuclear export signal 3. /evidence=ECO:0000250 404..413 3/8 (38%)
CSNK1E binding domain. /evidence=ECO:0000250 563..768 44/279 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..796 19/88 (22%)
Nuclear localization signal. /evidence=ECO:0000250 737..753 4/32 (13%)
Atrophin-1 752..>1063 CDD:460830 73/332 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 889..931 7/50 (14%)
Nuclear export signal 2. /evidence=ECO:0000250 933..940 3/7 (43%)
5 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]- [EKR]-[NST]-P 974..1063 18/88 (20%)
Period_C <1083..1185 CDD:463464 15/53 (28%)
CRY binding domain. /evidence=ECO:0000250 1132..1210 1/1 (100%)

Return to query results.
Submit another query.