DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment per and PER3

DIOPT Version :9

Sequence 1:	NP_001259194.1	Gene:	per / 31251	FlyBaseID:	FBgn0003068	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001276791.1	Gene:	PER3 / 8863	HGNCID:	8847	Length:	1210	Species:	Homo sapiens

Alignment Length:	1289	Identity:	269/1289 - (20%)
Similarity:	432/1289 - (33%)	Gaps:	344/1289 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 EKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQ 168
            |.|.|...|..::.:..|..::...|.|.:.:..:....|:::....||.....|:.:.|...::
Human     5 EAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFPSE 69

  Fly   169 SFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGE 233
            ....||.|.      ::.......|:...:|...:. .:....|....||..:...|....:...
Human    70 RRNKPSTLD------ALNYALRCVHSVQANSEFFQI-LSQNGAPQADVSMYSLEELATIASEHTS 127

  Fly   234 RVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAE 298
            : ..|:|..|.|...|.:::.:.....:|...:|:.....|:|.:..:|...|.:.        .
Human   128 K-NTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFYAH--------T 183

  Fly   299 SRGSVP---------------KDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAP 348
            :|..:|               ...|..||    |.||.:.........|....|:.:.:.....|
Human   184 ARAQLPFWNNWTQRAAARYECAPVKPFFC----RIRGGEDRKQEKCHSPFRIIPYLIHVHHPAQP 244

  Fly   349 E-EARPDNYMVSNGTNMLLVICAT---PIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAV 409
            | |:.|              .|.|   .|.|.|:.|...::::.  |...||...:...||..||
Human   245 ELESEP--------------CCLTVVEKIHSGYEAPRIPVNKRI--FTTTHTPGCVFLEVDEKAV 293

  Fly   410 SALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAG-ASFCSKPYRFLIQNGCYVLLET 473
            ..||||||||||.||:.:.|.||.|:|...::.|:|   .|| ..|...|.||..|||.|::|::
Human   294 PLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK---YAGHPPFEHSPIRFCTQNGDYIILDS 355

  Fly   474 EWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETV 538
            .|:|||||||||:.|::|.|:|...|...:||    ..|:|...:.....|.::|.|.|.|.:.|
Human   356 SWSSFVNPWSRKISFIIGRHKVRTSPLNEDVF----ATKIKKMNDNDKDITELQEQIYKLLLQPV 416

  Fly   539 S----------RPSDTVKQEVSRRCQALASFMET---LMDEVSRADLKLELPHEN---------- 580
            .          ..|.:.:|.||     :||..|.   .::|.....:.|:..:.:
Human   417 HVSVSSGYGSLGSSGSQEQLVS-----IASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQ 476

  Fly   581 ----ELTVSERDSVMLGEISPH------------------HDYYDSKS----------STETPPS 613
                .:|.|....|......|:                  |....:.|          :.|..||
Human   477 LYIESMTKSSFKPVTGTRTEPNGGGESANGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPS 541

  Fly   614 YNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTT 678
            |.|:|..::::|:..|..:             |..:..|:|..:...|...|......:......
Human   542 YQQINCIDSVIRYLKSYNI-------------PALKRKCISCTNTTSSSSEEDKQNHKADDVQAL 593

  Fly   679 ASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSG 743
            .:.:.:.::..:.:. |.|....||.|......|..
Human   594 QAGLQIPAIPKSEMP-TNGRSIDTGGGAPQILSTAM----------------------------- 628

  Fly   744 TGTGTASSSKGGSAAI----PPVT-----------------------------LTESLLNKHNDE 775
            ...|:..|..|.|:.|    ||.|                             ||.::|:.|..:
Human   629 LSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGLTAAVLSAHTQK 693

  Fly   776 MEKFMLKKHRESRGRTGEKSKKSANDTLKMLE--YSGPGHGIKRGGSHSWEGEANKPKQQLTLGT 838
            .|:..:.|.||                 |:|.  ||          |:..:...:|.|.....|
Human   694 EEQNYVDKFRE-----------------KILSSPYS----------SYLQQESRSKAKYSYFQG- 730

  Fly   839 DAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAA 903
            |:......|||...|......                 .||...:::|.||:....|....|...
Human   731 DSTSKQTRSAGCRKGKHKRKK-----------------LPEPPDSSSSNTGSGPRRGAHQNAQPC 778

  Fly   904 AAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGL-------- 960
            ..:.|||...||...|.:....:|...|.|.|.:   |...|.....|....:..||
Human   779 CPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPL---PAATSPGREYAAPGTAPEGLHGLPLSEG 840

  Fly   961 ------FPTFYYIPASLT------PTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYM 1013
                  || |.|:...:|      |..|..||.....|..|.|.....|...::|         |
Human   841 LQPYPAFP-FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSA---------M 895

  Fly  1014 AGVMYPHPSLFYT-------------HPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNK 1065
            :..:.|.||:...             ||...:.::.       |...|.|| .|.|..|:|. ::
Human   896 SPTLDPPPSVTSQRREEEKWEAQSEGHPFITSRSSS-------PLQLNLLQ-EEMPRPSESP-DQ 951

  Fly  1066 SVYTTTPASMTKKVPGAFHSVTTPAQV----------QRPSSQSASV----------KTEPGSSA 1110
            ....|.|.:..:.|.|...|.::||..          :.||..:||.          .:.|.:||
Human   952 MRRNTCPQTEYQCVTGNNGSESSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASA 1016

  Fly  1111 --AVSDPCKK-EVPDSSPI-----PSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSF-- 1165
              ..|.|.|. ..|.:|.:     ||....:.:....|:.:|.:.......:..|...|.|.:
Human  1017 LSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLT 1081

  Fly  1166 SSFYSSFIKTTDGSESP--------PDTEKDPKHRKLKSMSTSESKIMEH--PE 1209
            ||.|||.| :.:|.:|.        |:..::|..|.::  .|.|..:|.:  ||
Human  1082 SSVYSSKI-SQNGQQSQDVQKKETFPNVAEEPIWRMIR--QTPERILMTYQVPE 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	19/109 (17%)
		PAS	238..>300	CDD:238075	11/61 (18%)
		PAS	388..495	CDD:238075	50/107 (47%)
		PAS_11	391..495	CDD:291273	50/104 (48%)
PER3	NP_001276791.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		8/44 (18%)
		Nuclear export signal 1. /evidence=ECO:0000250	55..64		1/8 (13%)
		PAS	285..377	CDD:238075	47/94 (50%)
		Nuclear export signal 3. /evidence=ECO:0000250	404..413		3/8 (38%)
		CSNK1E binding domain. /evidence=ECO:0000250	563..768		44/279 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..796		19/88 (22%)
		Nuclear localization signal. /evidence=ECO:0000250	737..753		4/32 (13%)
		Herpes_BLLF1	<756..1066	CDD:282904	71/331 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..931		7/50 (14%)
		Nuclear export signal 2. /evidence=ECO:0000250	933..940		3/7 (43%)
		5 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]- [EKR]-[NST]-P	974..1063		18/88 (20%)
		Period_C	<1083..1198	CDD:403366	15/53 (28%)
		CRY binding domain. /evidence=ECO:0000250	1132..1210		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156700
Domainoid	1	1.000	93	1.000	Domainoid score	I7545
eggNOG	1	0.900	-	-		E1_KOG3753
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41094
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3625
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.920