DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment per and Per2

DIOPT Version :10

Sequence 1:NP_525056.2 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_113866.1 Gene:Per2 / 63840 RGDID:61945 Length:1257 Species:Rattus norvegicus


Alignment Length:1338 Identity:274/1338 - (20%)
Similarity:459/1338 - (34%) Gaps:377/1338 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 SGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQG-----------AGQAQTLIS 93
            |.|.:|.:...|....|||     :::.:.|.|.....|:....|           ..:.:.|:.
  Rat     8 SPSPTSPTQEPGEPQPTQA-----VLQEDVDMSSGSSGNENCSTGRDSQGSDCDDSGKELRMLVE 67

  Fly    94 ASTSLEGRD--------EEKPRPSGTGCVEQQ------------ICRELQDQQHGEDHSEPQA-- 136
            :|.:....|        |.:..||.:||..:|            ..|||:.....:..::.:|  
  Rat    68 SSNTHPSPDDTFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLRELKVHLPADKKAKGKAST 132

  Fly   137 ----------IEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGV 191
                      ::|::..||..|....||:                  .|.||.:  ||.      
  Rat   133 LATLKYALRSVKQVKANEEYYQLLMSSES------------------QPCSVDV--PSY------ 171

  Fly   192 GHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERV--KEDSFCCVISMHDGIVLYT 254
                                  .:|.:.|:         ..|.:  ..|.|...:|:..|.:||.
  Rat   172 ----------------------TMEQVEGI---------TSEYIVKNSDMFAVAVSLVSGKILYI 205

  Fly   255 TPSITDVLGYPRDMWLGRSFIDFVHLKDRATFAS----------QITTGIPIAESRGSVPKDAKS 309
            :..:..:....:|.:....|::|:...|.:.|.|          .:::|:   :|......:.||
  Rat   206 SNQVAPIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVSSGL---DSFTQECMEEKS 267

  Fly   310 TFC-VMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPI 373
            .|| |.:.::.          ...:.|:|||:.....:..|:.       ...:.:..::.|..:
  Rat   268 FFCRVSVGKHH----------ENEIRYQPFRMTPYLVKVQEQK-------GAASQLCCLLLAERV 315

  Fly   374 KSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKE 438
            .|.|:.|.  :..:...|...||...:...||..||..|||||||||...::...|..|..:|..
  Rat   316 HSGYEAPR--IPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLA 378

  Fly   439 TYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCN 503
            .::.::   |.:|..|...|.||..:||.|:.|:|.|:||:||||||:.|::|.|:|..||...:
  Rat   379 IHKKIL---QASGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNED 440

  Fly   504 VFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETV-----------------------SRPSDTV 545
            ||.|:|..:.|....:....|   |.|.:.|.:.|                       :..||:.
  Rat   441 VFAASPCPEEKTPHPSVQELT---EQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSN 502

  Fly   546 KQE-----------VSRRCQALASFMETL--MDEVSRADLKLELPHE-NELTVSERDSVMLGEIS 596
            .||           .|.:.|:.:.|....  ..|.|.|:::...|.: ..:|..||||  .|...
  Rat   503 GQEESHWRRSGIFKTSGKSQSKSHFSPESGGQKEASVAEMQSSPPAQVRSVTTMERDS--SGASL 565

  Fly   597 PHHDYYDSKSSTETPP-SYNQLNYNENLLRFFNS--KPVTAPAELDPPKTEPPEPRGTCVSGASG 658
            |...:.:..:....|| ||.|::..::::|:..|  :..|...:.:.|...|         ....
  Rat   566 PKASFPEELTYKSQPPCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANIP---------SRKA 621

  Fly   659 PMSP-VHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGT 722
            .:|| :|.|.....|.....|..:.|:||:..                  .|......:.|...:
  Rat   622 TVSPGLHSGEAARSSKVTSHTEVSAHLSSLAL------------------PGKAESVVSLTSQCS 668

  Fly   723 GTGTGTGTG---------TGTGTGNGTNS-GTGTGTASSSKGGSAAIPPVTLTESLLNKHNDEME 777
            .:.|....|         |.....:|..| ....|..|..||   ::..:.||:.:|..|....|
  Rat   669 YSSTIVHVGDKKPQPELETVEDVASGPESQDDAAGGLSQEKG---SLQKLGLTKEVLAAHTQREE 730

  Fly   778 KFMLKKHRESRGRTG-----------EKSKKSANDTLKMLEYSGPGHGIKR--GGSHSWE--GEA 827
            :..|::.||. .|.|           |:|:..|:|           .|::.  |...||:  |:.
  Rat   731 QGFLQRFREV-SRLGALQAHCQNYLQERSRAPASD-----------RGLRNASGIESSWKKTGKN 783

  Fly   828 NKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPG 892
            .|.|.:.....|:.:        :.|:||..|....:.|...:    |.:|    :.||.:..|.
  Rat   784 RKLKSKRVKTRDSSE--------STGSGGPVSHRPPLVGLNAT----AWSP----SDTSQSSCPS 832

  Fly   893 ----------------GAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQ-NINLWP-PFSVGI 939
                            ..|.....|...|..|::..|.:.|   ..|..|| ...:.| ||:..:
  Rat   833 APFPAPVPAYPLPVFPAPGIVSTPGTVVAPPAAAHTGFTMP---VVPMGTQPEFAVQPLPFAAPL 894

  Fly   940 TP---------PVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSP---RMHKHPHKGGTD 992
            .|         |.......:.|:.|.|...||....:.:.:||.|....|   .|.:.|    ..
  Rat   895 APVMAFMLPSYPFPPATPNLPQAFFPSQPHFPAHPTLASEITPASQAEFPSRTSMLRQP----CA 955

  Fly   993 MPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPL 1057
            .|.|......|..:|            .|.||.:..::             |...|.||:.|.|.
  Rat   956 CPVTPPAGTVALGRA------------SPPLFQSRGSS-------------PLQLNLLQLEEAPE 995

  Fly  1058 GSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPD 1122
            .|..|......|.|.||......|                  ||...:|.:....|:|...:..|
  Rat   996 SSTGAAGTLGTTGTAASGLDCTSG------------------ASRDRQPKAPPTCSEPSDTQNSD 1042

  Fly  1123 S-SPIPSVMGDYNSDPPCSSSNPANNKK----YTDSNGNSD---DMD----GSSFSSFYSSFIKT 1175
            : |....::.....:..||::..|.::.    .:||.|:|.   |..    |||.:|..|.:..:
  Rat  1043 AISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGCDTSRSGAGSSDTSHTSKYFGS 1107

  Fly  1176 TDGSESPPDTEKDPKHRKLKSMSTSESK-----IMEHP 1208
            .|.||:        .|:......|.||:     :::.|
  Rat  1108 IDSSEN--------NHKAKMITDTEESEQFIKYVLQDP 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
perNP_525056.2 PAS 238..333 CDD:395786 19/105 (18%)
PAS 388..495 CDD:238075 42/106 (40%)
Per2NP_113866.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 11/55 (20%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:O54943 109..118 3/8 (38%)
LXXLL 306..310 0/3 (0%)
PAS_3 344..428 CDD:430001 37/86 (43%)
PRK10263 <445..>982 CDD:236669 119/631 (19%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:O54943 460..469 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..567 18/97 (19%)
Important for protein stability. /evidence=ECO:0000269|PubMed:18782782 478..482 0/3 (0%)
CSNK1E binding domain. /evidence=ECO:0000250|UniProtKB:O54943 510..709 42/227 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 678..706 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..833 21/102 (21%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:11533252 778..794 3/15 (20%)
PHA03247 <790..1038 CDD:223021 61/313 (19%)
Interaction with PPARG. /evidence=ECO:0000250|UniProtKB:O54943 882..1067 45/231 (19%)
Nuclear export signal 3. /evidence=ECO:0000250|UniProtKB:O54943 983..990 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 993..1044 14/68 (21%)
Period_C 1040..1210 CDD:463464 23/106 (22%)
LXXLL 1051..1055 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1108 10/37 (27%)
CRY binding domain. /evidence=ECO:0000269|PubMed:11533252 1157..1257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257
Blue background indicates that the domain is not in the aligned region.

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