DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment per and Per2

DIOPT Version :9

Sequence 1:	NP_001259194.1	Gene:	per / 31251	FlyBaseID:	FBgn0003068	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_113866.1	Gene:	Per2 / 63840	RGDID:	61945	Length:	1257	Species:	Rattus norvegicus

Alignment Length:	1338	Identity:	274/1338 - (20%)
Similarity:	459/1338 - (34%)	Gaps:	377/1338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQG-----------AGQAQTLIS 93
            |.|.:|.:...|....|||     :::.:.|.|.....|:....|           ..:.:.|:.
  Rat     8 SPSPTSPTQEPGEPQPTQA-----VLQEDVDMSSGSSGNENCSTGRDSQGSDCDDSGKELRMLVE 67

  Fly    94 ASTSLEGRD--------EEKPRPSGTGCVEQQ------------ICRELQDQQHGEDHSEPQA-- 136
            :|.:....|        |.:..||.:||..:|            ..|||:.....:..::.:|
  Rat    68 SSNTHPSPDDTFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLRELKVHLPADKKAKGKAST 132

  Fly   137 ----------IEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGV 191
                      ::|::..||..|....||:                  .|.||.:  ||.
  Rat   133 LATLKYALRSVKQVKANEEYYQLLMSSES------------------QPCSVDV--PSY------ 171

  Fly   192 GHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERV--KEDSFCCVISMHDGIVLYT 254
                                  .:|.:.|:         ..|.:  ..|.|...:|:..|.:||.
  Rat   172 ----------------------TMEQVEGI---------TSEYIVKNSDMFAVAVSLVSGKILYI 205

  Fly   255 TPSITDVLGYPRDMWLGRSFIDFVHLKDRATFAS----------QITTGIPIAESRGSVPKDAKS 309
            :..:..:....:|.:....|::|:...|.:.|.|          .:::|:   :|......:.||
  Rat   206 SNQVAPIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVSSGL---DSFTQECMEEKS 267

  Fly   310 TFC-VMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPI 373
            .|| |.:.::.          ...:.|:|||:.....:..|:.       ...:.:..::.|..:
  Rat   268 FFCRVSVGKHH----------ENEIRYQPFRMTPYLVKVQEQK-------GAASQLCCLLLAERV 315

  Fly   374 KSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKE 438
            .|.|:.|.  :..:...|...||...:...||..||..|||||||||...::...|..|..:|..
  Rat   316 HSGYEAPR--IPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLA 378

  Fly   439 TYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCN 503
            .::.::   |.:|..|...|.||..:||.|:.|:|.|:||:||||||:.|::|.|:|..||...:
  Rat   379 IHKKIL---QASGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNED 440

  Fly   504 VFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETV-----------------------SRPSDTV 545
            ||.|:|..:.|....:....|   |.|.:.|.:.|                       :..||:.
  Rat   441 VFAASPCPEEKTPHPSVQELT---EQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSN 502

  Fly   546 KQE-----------VSRRCQALASFMETL--MDEVSRADLKLELPHE-NELTVSERDSVMLGEIS 596
            .||           .|.:.|:.:.|....  ..|.|.|:::...|.: ..:|..||||  .|...
  Rat   503 GQEESHWRRSGIFKTSGKSQSKSHFSPESGGQKEASVAEMQSSPPAQVRSVTTMERDS--SGASL 565

  Fly   597 PHHDYYDSKSSTETPP-SYNQLNYNENLLRFFNS--KPVTAPAELDPPKTEPPEPRGTCVSGASG 658
            |...:.:..:....|| ||.|::..::::|:..|  :..|...:.:.|...|         ....
  Rat   566 PKASFPEELTYKSQPPCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANIP---------SRKA 621

  Fly   659 PMSP-VHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGT 722
            .:|| :|.|.....|.....|..:.|:||:..                  .|......:.|...:
  Rat   622 TVSPGLHSGEAARSSKVTSHTEVSAHLSSLAL------------------PGKAESVVSLTSQCS 668

  Fly   723 GTGTGTGTG---------TGTGTGNGTNS-GTGTGTASSSKGGSAAIPPVTLTESLLNKHNDEME 777
            .:.|....|         |.....:|..| ....|..|..||   ::..:.||:.:|..|....|
  Rat   669 YSSTIVHVGDKKPQPELETVEDVASGPESQDDAAGGLSQEKG---SLQKLGLTKEVLAAHTQREE 730

  Fly   778 KFMLKKHRESRGRTG-----------EKSKKSANDTLKMLEYSGPGHGIKR--GGSHSWE--GEA 827
            :..|::.||. .|.|           |:|:..|:|           .|::.  |...||:  |:.
  Rat   731 QGFLQRFREV-SRLGALQAHCQNYLQERSRAPASD-----------RGLRNASGIESSWKKTGKN 783

  Fly   828 NKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPG 892
            .|.|.:.....|:.:        :.|:||..|....:.|...:    |.:|    :.||.:..|.
  Rat   784 RKLKSKRVKTRDSSE--------STGSGGPVSHRPPLVGLNAT----AWSP----SDTSQSSCPS 832

  Fly   893 ----------------GAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQ-NINLWP-PFSVGI 939
                            ..|.....|...|..|::..|.:.|   ..|..|| ...:.| ||:..:
  Rat   833 APFPAPVPAYPLPVFPAPGIVSTPGTVVAPPAAAHTGFTMP---VVPMGTQPEFAVQPLPFAAPL 894

  Fly   940 TP---------PVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSP---RMHKHPHKGGTD 992
            .|         |.......:.|:.|.|...||....:.:.:||.|....|   .|.:.|    ..
  Rat   895 APVMAFMLPSYPFPPATPNLPQAFFPSQPHFPAHPTLASEITPASQAEFPSRTSMLRQP----CA 955

  Fly   993 MPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPL 1057
            .|.|......|..:|            .|.||.:..::             |...|.||:.|.|.
  Rat   956 CPVTPPAGTVALGRA------------SPPLFQSRGSS-------------PLQLNLLQLEEAPE 995

  Fly  1058 GSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPD 1122
            .|..|......|.|.||......|                  ||...:|.:....|:|...:..|
  Rat   996 SSTGAAGTLGTTGTAASGLDCTSG------------------ASRDRQPKAPPTCSEPSDTQNSD 1042

  Fly  1123 S-SPIPSVMGDYNSDPPCSSSNPANNKK----YTDSNGNSD---DMD----GSSFSSFYSSFIKT 1175
            : |....::.....:..||::..|.::.    .:||.|:|.   |..    |||.:|..|.:..:
  Rat  1043 AISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGCDTSRSGAGSSDTSHTSKYFGS 1107

  Fly  1176 TDGSESPPDTEKDPKHRKLKSMSTSESK-----IMEHP 1208
            .|.||:        .|:......|.||:     :::.|
  Rat  1108 IDSSEN--------NHKAKMITDTEESEQFIKYVLQDP 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	19/105 (18%)
		PAS	238..>300	CDD:238075	13/71 (18%)
		PAS	388..495	CDD:238075	42/106 (40%)
		PAS_11	391..495	CDD:291273	42/103 (41%)
Per2	NP_113866.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		11/55 (20%)
		Nuclear export signal 1. /evidence=ECO:0000250\|UniProtKB:O54943	109..118		3/8 (38%)
		LXXLL	306..310		0/3 (0%)
		PAS	331..432	CDD:238075	42/103 (41%)
		PAS_3	344..428	CDD:285623	37/86 (43%)
		Nuclear export signal 2. /evidence=ECO:0000250\|UniProtKB:O54943	460..469		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..567		18/97 (19%)
		Important for protein stability	478..482		0/3 (0%)
		CSNK1E binding domain	555..763		48/240 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	678..706		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..833		21/102 (21%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11533252	778..794		3/15 (20%)
		Interaction with PPARG. /evidence=ECO:0000250\|UniProtKB:O54943	882..1067		45/231 (19%)
		Nuclear export signal 3. /evidence=ECO:0000250\|UniProtKB:O54943	983..990		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1044		14/68 (21%)
		Period_C	1040..1234	CDD:288930	23/106 (22%)
		LXXLL	1051..1055		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1070..1108		10/37 (27%)
		CRY binding domain. /evidence=ECO:0000269\|PubMed:11533252	1157..1257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1226..1257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350616
Domainoid	1	1.000	89	1.000	Domainoid score	I7651
eggNOG	1	0.900	-	-		E1_KOG3753
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I3978
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45233
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11269
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980