Protein Alignment per and per3

DIOPT Version :9

• Sequence 1: NP_001259194.1
• Gene: per / 31251
• FlyBaseID: FBgn0003068
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_571659.1
• Gene: per3 / 58107
• ZFINID: ZDB-GENE-000804-1
• Length: 1281
• Species: Danio rerio
• Alignment Length: 1368
• Identity: 277/1368 - (20%)
• Similarity: 458/1368 - (33%)
• Gaps: 342/1368 - (25%)

  Fly     4 GESTESTHNTKVSDSAYSNSCSNSQSQRSGS---------SKSRLSGSHSSGSSGYGGKPS---- 55
            ||...|:....:.......:.|......||:         ::.|: |..|||....||:.:
Zfish    10 GEQENSSPGPDIHTGQTDQTSSGQDPGTSGNISASGEEEEAEERI-GRRSSGCEESGGEQTHEDV 73

  Fly    56 ------TQASSSDMIIKRNKDKSR---------KKKKNKGAGQGAGQAQTLISASTSLEGRDEEK 105
                  |.:|.:|.|..|:....|         ....:.|:..|:|..::..||:.|........
Zfish    74 DMNSTHTSSSGNDSIHHRHHHHHRHHHHHHHHSSSNCSPGSTTGSGSTKSSKSATGSSSSSFHST 138

  Fly   106 PRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEE--DQSGSESEADRVEG-------V 161
            ..   |.|.||        .:.|.:|:..:.:..:|:.::.  .:..|.|:|..||.       |
Zfish   139 HH---TECGEQ--------TETGREHTHREMMHTVQEMKKRLPSEKRSRSKASTVEALHYALNCV 192

  Fly   162 AKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAA 226
            .:.:|...:                      :...:.|||   |:..:|....||.:.|.
Zfish   193 KQVQANSEY----------------------YNLLMSSGL---DERRDATVCTLEELEGF----- 227

  Fly   227 GTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQIT 291
             |.:...: ..|||..|.|:..|.|:|.:...:.||...|.......|::.::.:|...|.|.
Zfish   228 -TSEHTLK-NTDSFVVVFSLASGKVVYASEQASSVLHCKRKFLESAKFVEMLYHQDVNVFYSH-- 288

  Fly   292 TGIPIAESRGSVPKDA---------KSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLG---LTF 344
            |..|...|.......|         ||.||    |.||.|..     ...:.|.|||:.   |..
Zfish   289 TAQPRLPSWNLGTDSAAVLFECAQVKSFFC----RIRGGKDR-----DGDMRYSPFRITPYLLKV 344

  Fly   345 REAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAV 409
            :.:..|..|           ..:..|..|.|.|:.|...:.::.  |:..|:...:...||..||
Zfish   345 QGSSGEEEP-----------CCLALAERIISGYEAPRIPMDKRI--FSTTHSPGCVFLEVDDRAV 396

  Fly   410 SALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMK-KGQTAGASFCSKPYRFLIQNGCYVLLET 473
            ..||||||||||.|::...|.:|..:|...:..::| .||   ..|...|.||..|||.||.|::
Zfish   397 PLLGYLPQDLIGTSVLTCLHPDDRLLMLAMHRKIVKYAGQ---PPFEHSPIRFRCQNGDYVTLDS 458

  Fly   474 EWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRL---- 534
            .|:||:||||||:.|::|.|:|..||...:||.|    :.|..:.....:.:..:.::.:|
Zfish   459 SWSSFINPWSRKVAFIIGRHKVRTGPLNEDVFAA----RSKADQPVMCEDVKELQAMIHKLFLQP 519

  Fly   535 --------------------AETVSRPSDT---VKQEVSRRCQALASFMETLMDEVSRADLKLEL 576
                                ..:|:..||:   :.::..|....|..|... :::|.....:..|
Zfish   520 VHNNGSSGYGSLGSNGSHEHYISVASSSDSNGNLWEDSHRETMTLQQFCAD-VNKVKNWGQQAYL 583

  Fly   577 PHENELTVSERDSVMLG---EISPHHDY-------YDSKSSTETP--PSYNQLNYNENLLRFFNS 629
            ....:||.....:.:.|   ..|..||.       ...:.:.:.|  |||.|:|..::::|:..|
Zfish   584 ESRKKLTALGPATAVAGAGVHASSSHDLGIRDHLKQSLQKARKQPHIPSYQQINCVDSIIRYLES 648

  Fly   630 KPVTAPAELDPPKTEP---PEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTS 691
            ...:|...    |.|.   .....:..|....|.:..||.:..:.........|.:...|.|..:
Zfish   649 CATSALKR----KCESLSITTSSSSSTSEEDKPTAAAHENTDEAALDAARALDSQVSAGSATTAA 709

  Fly   692 IAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGT---------------GTGTGTGTGTGTGNGTN 741
            :.|...|.....|   ......:.|...:.:.|               ....|:..........:
Zfish   710 VVGAPLTDITIST---EAMSVVSVTSQCSYSSTIVHVPQPESEVTALEDAPMGSEPADSAPAPAS 771

  Fly   742 SGTGTGTASSSKGGSAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKML 806
            ....:|:||:|:   ..:..:.||:.:|:.|..:.|:..:.:.|       .:..:|...:....
Zfish   772 PAHDSGSASTSQ---EELLVLGLTKEVLSAHTQKEEQQFVDRFR-------HRIVQSPYSSYLQQ 826

  Fly   807 EYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSG 871
            :.|...|...||.......:..:||
Zfish   827 DNSSNAHSHHRGDVVRQPNKHKRPK---------------------------------------- 851

  Fly   872 TGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFS 936
                  ||. ::.:.....||......|..||..:...|| .||.|.||       ||...||.:
Zfish   852 ------PED-SSDSYECSQPGNYWSLPGPTAAPHSSWPSS-ESSQPPPS-------NIGFVPPMA 901

  Fly   937 VGI-TPPVHS-----THTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTDMPT 995
            |.: |||..:     ....|.|.......|.|        :||......|....:|...|...|
Zfish   902 VPMQTPPYFNIIGADQQPVMLQPDPGVQNLQP--------MTPMMVVLLPSFPMYPPNNGMYFP- 957

  Fly   996 TSQQAAAAAAQAMPLQ----YMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERP 1056
                  .||...:|..    ...|...|..:....|...:|...:..:|.         .|||..
Zfish   958 ------MAAPGVVPYNIGGFVPPGTPMPAEAPLQGHNLESAGVGVPAEPD---------SIPEPW 1007

  Fly  1057 LGS--QSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPS---------SQSASVKTEPG--- 1107
            .|.  .:|...::::::.:|...::......:|.|::.|..:         :::...::|.|
Zfish  1008 FGEDLDAAQPTALFSSSRSSSPIQLNLLQEELTKPSEAQTSTNADSLHEHHTKTDDARSECGHQD 1072

  Fly  1108 ---SSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFY 1169
               ||:.:.|...:|...|....:..|..:.:    |.....:.....|||.|....|||.||.|
Zfish  1073 AHSSSSEMLDQLLQEDARSGTGSNASGSGSGE----SGGSLGSGSGLGSNGTSTSHTGSSNSSKY 1133

  Fly  1170 SSFIKTTDGSESPPDTEKDPKHRKLKSMSTSE-------------SKIMEHPE----------ED 1211
            .:       |....||.:  |.||.......|             |.|.:.||          .|
Zfish  1134 FA-------SNDSSDTSR--KARKSAEAQERERSGFKKHVDDPLWSMIKQTPEPVMLTYQISSRD 1189

  Fly  1212 QTQ 1214
            |.|
Zfish  1190 QAQ 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	27/103 (26%)
		PAS	238..>300	CDD:238075	17/61 (28%)
		PAS	388..495	CDD:238075	45/107 (42%)
		PAS_11	391..495	CDD:291273	45/104 (43%)
per3	NP_571659.1	PAS	388..480	CDD:238075	43/94 (46%)
		PAS_3	388..476	CDD:285623	41/90 (46%)
		Period_C	1070..1266	CDD:288930	31/136 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592324
Domainoid	1	1.000	83	1.000	Domainoid score	I8273
eggNOG	1	0.900	-	-		E1_KOG3753
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4269
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11269
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3625
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.010