DRSC/TRiP Functional Genomics Resources

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Protein Alignment per and PER1

DIOPT Version :9

Sequence 1:NP_001259194.1 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_002607.2 Gene:PER1 / 5187 HGNCID:8845 Length:1290 Species:Homo sapiens


Alignment Length:1394 Identity:286/1394 - (20%)
Similarity:443/1394 - (31%) Gaps:476/1394 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNK 79
            ::|...:||        :|||.:..:|..|.|:|......|:..:..|..:....:.|:......
Human    41 LADDTDANS--------NGSSGNESNGHESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQS 97

  Fly    80 GAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICR-----ELQDQQHGEDHSEPQAIEQ 139
            .:...:..|.:|:|||:       |:..||.:||..:|..|     ||.           .|:.:
Human    98 PSPPSSSIAYSLLSASS-------EQDNPSTSGCSSEQSARARTQKELM-----------TALRE 144

  Fly   140 LQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLA-- 202
            |:..                                     :||...|.|..|..|.|...||  
Human   145 LKLR-------------------------------------LPPERRGKGRSGTLATLQYALACV 172

  Fly   203 -------KFDKTWEAGPGKLESMTGVGAAAAGTGQRGERV-------KEDSFCCVISMHDGIVLY 253
                   ::.:.|....|:..||.    .:..|.:..|.:       .:|:|...:|...|.::|
Human   173 KQVQANQEYYQQWSLEEGEPCSMD----MSTYTLEELEHITSEYTLQNQDTFSVAVSFLTGRIVY 233

  Fly   254 TTPSITDVLGYPRDMWLGRSFIDFVHLKDRATF-ASQITTGIP---IAESRGSVPKD---AKSTF 311
            .:.....:|...||::.|..|.:.:..:|...| .|...:.:|   ...|.||..:|   .||.|
Human   234 ISEQAAVLLRCKRDVFRGTRFSELLAPQDVGVFYGSTAPSRLPTWGTGASAGSGLRDFTQEKSVF 298

  Fly   312 CVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNG--TNMLLVICATPIK 374
            |    |.||......|     ..|:||||      .|...:   ..||:|  .....::.|..|.
Human   299 C----RIRGGPDRDPG-----PRYQPFRL------TPYVTK---IRVSDGAPAQPCCLLIAERIH 345

  Fly   375 SSYKV----PDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSV 435
            |.|:.    ||:.:      |..|||.:.:...||..|...||||||||:|..::.|.|.||..:
Human   346 SGYEAPRIPPDKRI------FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPEDRPL 404

  Fly   436 MKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPK 500
            |...::.::   |.||..|...|.||..:||.||.::|.|..||:|||||:.||:|.|:|...|.
Human   405 MLAIHKKIL---QLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSRKVAFVLGRHKVRTAPL 466

  Fly   501 QCNVF-----EAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDT---------------- 544
            ..:||     ..||:....|.|        :.|.|.:.|.:.|..||.|                
Human   467 NEDVFTPPAPSPAPSLDTDIQE--------LSEQIHRLLLQPVHSPSPTGLCGVGAVTSPGPLHS 523

  Fly   545 ---------------------VKQEVSR-----RCQALASFMETLMDEVSRADLKL-------EL 576
                                 ..|::.:     :.|....|:|:.....||..|..       .|
Human   524 PGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIESRARPQSRPRLPATGTFKAKAL 588

  Fly   577 PHEN---ELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAEL 638
            |.::   ||............:.|........||.    ||.|:|..:::||:..|..:      
Human   589 PCQSPDPELEAGSAPVQAPLALVPEEAERKEASSC----SYQQINCLDSILRYLESCNL------ 643

  Fly   639 DPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTG 703
                  |...:..|                  .||.::||      ||.::.....||....||.
Human   644 ------PSTTKRKC------------------ASSSSYTT------SSASDDDRQRTGPVSVGTK 678

  Fly   704 TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNS-------------------------- 742
            ....:...:|.|.........|   ||.:.....|...|                          
Human   679 KDPPSAALSGEGATPRKEPVVG---GTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESD 740

  Fly   743 --------GTGTGTASSSKGGSAAIP--------PVTLTESLLNKHNDEMEKFMLKKHRESRGRT 791
                    |...|.|.|........|        ||.||:::|:.|..:.|:..|.:.|:.....
Human   741 IIMMEDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRLR 805

  Fly   792 GEKSKKSANDTL-KMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTG 855
            |..|..:|...| :...:.||....:|   |....:|.:.:....                    
Human   806 GLDSSSTAPSALGERGCHHGPAPPSRR---HHCRSKAKRSRHHQN-------------------- 847

  Fly   856 GVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPS 920
                                                            ..|.|...|...:|.|.
Human   848 ------------------------------------------------PRAEAPCYVSHPSPVPP 864

  Fly   921 SYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKH 985
            |.|        ||      |||..:...|:.|               |..|    |..|||    
Human   865 STP--------WP------TPPATTPFPAVVQ---------------PYPL----PVFSPR---- 892

  Fly   986 PHKGGTD----MPTTSQQAAAAAAQAMPL--QYMAGVMYPHPSLF----YTHPAAAAATAMMYQP 1040
               ||..    .||:...||..|....|:  ..:...::|.||.:    ...||....|...:.|
Human   893 ---GGPQPLPPAPTSVPPAAFPAPLVTPMVALVLPNYLFPTPSSYPYGALQTPAEGPPTPASHSP 954

  Fly  1041 MP-FPGMA-NALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHS-VTTPAQV------QRPS 1096
            .| .|.:| :....|:.||                         |:| .::|.|:      :.|.
Human   955 SPSLPALAPSPPHRPDSPL-------------------------FNSRCSSPLQLNLLQLEELPR 994

  Fly  1097 SQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSN------PANNKKYTDS-- 1153
            ::.|:|...|||||....|..:.....:.:..|....|.|....||:      ..:::..|.|  
Human   995 AEGAAVAGGPGSSAGPPPPSAEAAEPEARLAEVTESSNQDALSGSSDLLELLLQEDSRSGTGSAA 1059

  Fly  1154 -----------NGNSDDMDG--------SSFSSFYSSFIKTTDGSESPPDTEK---DPKHRKLK- 1195
                       :|:.....|        ||.||..|.:..:.|.||:.....:   :|..:.:| 
Human  1060 SGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSIDSSEAEAGAARGGAEPGDQVIKY 1124

  Fly  1196 --------SMSTSESKIM---EHPEEDQT 1213
                    .|:.::.::|   :.|..|.|
Human  1125 VLQDPIWLLMANADQRVMMTYQVPSRDMT 1153

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
perNP_001259194.1 PAS 238..333 CDD:279347 26/101 (26%)
PAS 238..>300 CDD:238075 14/65 (22%)
PAS 388..495 CDD:238075 45/106 (42%)
PAS_11 391..495 CDD:291273 45/103 (44%)
PER1NP_002607.2 Interaction with BTRC. /evidence=ECO:0000269|PubMed:15917222 1..151 29/172 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..134 25/107 (23%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:O54943 138..147 3/19 (16%)
PAS 360..461 CDD:238075 45/103 (44%)
PAS_3 373..457 CDD:285623 39/86 (45%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:O35973 489..498 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..544 0/35 (0%)
Required for phosphorylation by CSNK1E. /evidence=ECO:0000250 596..815 48/261 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..698 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 749..772 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..874 21/153 (14%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O35973 827..843 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 938..977 11/63 (17%)
Nuclear export signal 3. /evidence=ECO:0000250|UniProtKB:O54943 982..989 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 996..1037 11/40 (28%)
LXXLL 1043..1047 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1051..1098 9/46 (20%)
Period_C <1083..1224 CDD:288930 15/71 (21%)
CRY binding domain. /evidence=ECO:0000250 1149..1290 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1207..1290
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156699
Domainoid 1 1.000 93 1.000 Domainoid score I7545
eggNOG 1 0.900 - - E1_KOG3753
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 159 1.000 Inparanoid score I4264
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41094
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11269
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X975
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.890

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