Protein Alignment per and per

DIOPT Version :10

• Sequence 1: NP_525056.2
• Gene: per / 31251
• FlyBaseID: FBgn0003068
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_061504747.1
• Gene: per / 4577060
• VectorBaseID: AGAMI1_008356
• Length: 1721
• Species: Anopheles gambiae
• Alignment Length: 1705
• Identity: 582/1705 - (34%)
• Similarity: 739/1705 - (43%)
• Gaps: 626/1705 - (36%)

  Fly     1 MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASS----S 61
            ||..|..:||||||||||||||||||||||||||||||.|||:||||||||||.||||||    .
Mosquito     6 MENLEGADSTHNTKVSDSAYSNSCSNSQSQRSGSSKSRHSGSNSSGSSGYGGKASTQASSIAPLP 70

  Fly    62 DMIIKRNKDKSRKKKK-------------NKGAGQGAGQAQTLISASTSLEG----RDEEKPRPS 109
            ....||.|||.|||||             |..||.|...|.|..:|:.::..    .|.|:...:
Mosquito    71 QAAAKRTKDKERKKKKLKTSTDSGTVPAPNGSAGPGGVTAGTAPNAAGTVANANAVSDVEQQTLA 135

  Fly   110 GTGCVEQQ-------------ICREL----------QDQQHGEDHSE------------------ 133
            ..||.|.:             :..||          |...||.:.:|
Mosquito   136 AGGCGEPEPMETTTGNSSVASVSGELGAVGAGAGGMQSASHGGESNEHHELGTVSGGNGTAELVS 200

  Fly   134 -----PQAIEQLQQEE--EEDQSG-SESEADRV------EGVAKSEAAQSF---PIPSPLSVTIV 181
                 ..|:.|:..||  ::|:.. |:.:..|.      :|..||..|||.   |.|.|..|..:
Mosquito   201 VEVAAAAAVAQIINEENTKDDRKHLSQEQLHRAGGGGTHDGRQKSLVAQSILPGPAPLPAGVASI 265

  Fly   182 PPSMG-GCG-------------GV----------------GHAAGL------------------- 197
            ..|:. |.|             ||                .|..||
Mosquito   266 VNSIATGAGLRTGSVSSSGTLLGVVQQQQQHQQHQQQQQQQHHGGLNQCQQKQTQHHHHHHGAHQ 330

  Fly   198 ----------DSGLAK--------------------FDKTW---EAGPGKLESMTGVGAAA---A 226
                      |..||.                    .||..   :..|.:.:........|   :
Mosquito   331 HPKQQHSSMQDPSLANQKHVPQQHSAQQPHHQQQQPLDKQHLQPQQQPQQQQQQQQQQQQAQPQS 395

  Fly   227 GTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQIT 291
            .|.:..:...||.||||||||||:||:||||||..||:|:|||||||||||||.|||||||||||
Mosquito   396 NTPRTNKPDVEDGFCCVISMHDGVVLFTTPSITHSLGFPKDMWLGRSFIDFVHPKDRATFASQIT 460

  Fly   292 TG--IPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPD 354
            :.  :|:.||: |..||.|::..||||:|||||:.||||....|:|||:||.|||||||.|
Mosquito   461 SKVVVPLGESK-SGQKDQKNSLYVMLRKYRGLKTAGFGVTKTTVNYEPYRLVLTFREAPAE---- 520

  Fly   355 NYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDL 419
            |..:.:|.::||:|.|||:||.||.|:|.|.::..||:.|||.:|::|:||..:|.::||||||:
Mosquito   521 NAEIISGRSILLIISATPVKSVYKEPNESLCERDLKFSTRHTTSGVLSYVDGNSVESIGYLPQDI 585

  Fly   420 IGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSR 484
            :|||||:.||.:|:.::::.|||||.|||||||||.|:|||||:.||||::|.||||||||||||
Mosquito   586 LGRSIMELYHPDDMPILRKAYETVMVKGQTAGASFVSQPYRFLVNNGCYIVLSTEWTSFVNPWSR 650

  Fly   485 KLEFVVGHHRVFQGPKQCNVFEAAP-TCKL--KISEEAQSRNTRIKEDIVKRLAETVSRPSDTVK 546
            :||||:||||:.|||...:||..:| .|:.  :.|::.......::|.|::.|.|.|::|||.||
Mosquito   651 ELEFVIGHHRILQGPSIADVFAVSPFYCQTQNQFSDDTLKEAKMVEEQILRLLKEPVAKPSDMVK 715

  Fly   547 QEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETP 611
            ||||:||:|||||||.|||||::.:|||.|.:|::.|.|||||||||||||||:|:|||||:|||
Mosquito   716 QEVSKRCKALASFMEELMDEVAQPELKLNLLNESDFTFSERDSVMLGEISPHHEYFDSKSSSETP 780

  Fly   612 PSYNQLNYNENLLRFFNSKP---VTAPAELDP---PKTE-----------PPEPRGTCVSGASGP 659
            ||||||||||||.|||:|:|   :....::|.   ..||           .|..||...||
Mosquito   781 PSYNQLNYNENLQRFFDSRPAMNIEEQMKMDSSGGTNTETIGDEQQSHAVSPNQRGFSASG---- 841

  Fly   660 MSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGT 724
                  |.|..||:|||::.||..|.|.|||: :.|||||
Mosquito   842 ------GGGSGGSAGNFSSESNAQMDSTTNTT-SNTGGTG------------------------- 874

  Fly   725 GTGTGTGTGTGTGNGTNSGTGTGTASSSKGGSAAIPPVTLTESLLNKHNDEMEKFMLKKHRESR- 788
                                ||||:|   ||..:..|.||||.||.|||::|:|.|||||||:|
Mosquito   875 --------------------GTGTSS---GGGGSFQPPTLTEELLCKHNEDMQKVMLKKHREARM 916

  Fly   789 -GRTGEKSKKSANDTLKMLEYSG--PGHGIKRGGSHSWEGEANK--------------------- 829
             .|..:|:||...|   ...|.|  .|||:|||.||||||:|:|
Mosquito   917 VARGTDKNKKGPPD---KAGYGGGAVGHGVKRGSSHSWEGDAHKTIKHQHNPDGGGCSAMLQQQQ 978

  Fly   830 -----------------------------------------------------PKQQLTLGTD-- 839
                                                                 .:|||...|:
Mosquito   979 QQKMGPVAPHALQQQLLIQQQHQQLQQQQQQQQQQQQQQAQQQQQQLQQQQQQQQQQLYQQTNMH 1043

  Fly   840 ----------------AIKGAAGSA----GGAVGT------------------------------ 854
                            |::|...:|    ||.:.|
Mosquito  1044 MHYKTQHVSQQLQYHHALQGQGSAALQQTGGGMQTHLQQQQLLHHQQHQQQQQQQQHQHLSHPAP 1108

  Fly   855 ---------------GGVGSGGAG---VAGGGGSGTGVAGTPEGRAT-TTSGTGTPGGAGGGGGA 900
                           |.|.|..||   :|||...          |:| ||.....|..|.||
Mosquito  1109 SQQQQYPYQSPYHNNGPVQSTVAGESLLAGGSNQ----------RSTFTTPSILAPQMAYGG--- 1160

  Fly   901 GAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSF-SSAGLFPTF 964
                    :.:.|||..|.:.        :|||||||.:|....|.....:.:|| .|..:|||.
Mosquito  1161 --------AHTTGSSLTGRTG--------DLWPPFSVSVTTMQASAGAGSSAASFVPSHSIFPTL 1209

  Fly   965 YYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPL--QYM-AGVMYPHPSLFYT 1026
            |||||:..                           ||.||.|..|:  .|| ||||||||.|:
Mosquito  1210 YYIPAAAA---------------------------AATAAPQPAPITVPYMAAGVMYPHPQLY-- 1245

  Fly  1027 HPAAAAATAMMYQPMPF------------------------------------------------ 1043
            |..:.....|||..||:
Mosquito  1246 HQQSLLYPPMMYHAMPYQPLPPPCGLDSDTRNHQHQQHQQQQQQQQQQQQQQQQQQQQRQQQQQQ 1310

  Fly  1044 ----------------------PG---------------MANALQIPERPLGSQSAYNKSVYTTT 1071
                                  ||               .|.:.::|..|..:.|...|.
Mosquito  1311 QAQRLQPQPGHTTSTGGPGPAAPGGMSVGLGQPATGGQSSAQSAEVPGVPTNAGSGGGKH----- 1370

  Fly  1072 PASMTKKVP---GAFHSVTTPAQVQRPSSQSASVKTEPGS------------SAAVSDPCKKEVP 1121
            ||.||  ||   |:.....||  .||||||:.|||.||||            :.|.|:..||::.
Mosquito  1371 PAHMT--VPPSAGSGSQSQTP--FQRPSSQATSVKAEPGSALGSIASASIVVNRAFSESSKKDLT 1431

  Fly  1122 DSSPIPSV-----MGDYNSDPPCSSS--------NPANNKKY----------------------T 1151
            ||..|.:|     ..|...|..|.::        |.|..::.                      .
Mosquito  1432 DSPLISNVDCTDCALDEVHDKHCDTTATGIDRRVNGAGTRRTGSGQVDKLPMGTGIGGTAGNNGG 1496

  Fly  1152 DSNGN-------------SDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESK 1203
            |.||.             |||||.||||||||||:||.:.||.....|     ||..|....||.
Mosquito  1497 DRNGGGGGGGGVVGLGEVSDDMDESSFSSFYSSFLKTDNSSEGQNGAE-----RKESSEMCWESG 1556

  Fly  1204 IMEHPEEDQTQHGDG 1218
            ...........|.||
Mosquito  1557 SNNATSTTNRMHVDG 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_525056.2	PAS	238..333	CDD:395786	66/96 (69%)
		PAS	388..495	CDD:238075	68/106 (64%)
per	XP_061504747.1	None