DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment per and Per1

DIOPT Version :9

Sequence 1:	NP_001259194.1	Gene:	per / 31251	FlyBaseID:	FBgn0003068	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001152839.1	Gene:	Per1 / 18626	MGIID:	1098283	Length:	1291	Species:	Mus musculus

Alignment Length:	1368	Identity:	279/1368 - (20%)
Similarity:	444/1368 - (32%)	Gaps:	429/1368 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNK 79
            ::|...:||        :|||.:..:|..|.|:|......|:..:..|..:....:.|:......
Mouse    41 LADDTDANS--------NGSSGNESNGPESRGASQRSSHSSSSGNGKDSALLETTESSKSTNSQS 97

  Fly    80 GAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICR-----ELQDQQHGEDHSEPQAIEQ 139
            .:...:..|.:|:|||:       |:..||.:||..:|..|     ||.           .|:.:
Mouse    98 PSPPSSSIAYSLLSASS-------EQDNPSTSGCSSEQSARARTQKELM-----------TALRE 144

  Fly   140 LQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLA-- 202
            |:..                                     :||...|.|..|..|.|...||
Mouse   145 LKLR-------------------------------------LPPERRGKGRSGTLATLQYALACV 172

  Fly   203 -------KFDKTWEAGPGK----------LESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGI 250
                   ::.:.|....|:          ||.:..:      |.:...| .:|:|...:|...|.
Mouse   173 KQVQANQEYYQQWSLEEGEPCAMDMSTYTLEELEHI------TSEYTLR-NQDTFSVAVSFLTGR 230

  Fly   251 VLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQIT-TGIP---IAESRGSVPKD---AK 308
            ::|.:.....:|...||::.|..|.:.:..:|...|....| :.:|   ...|.||..||   .|
Mouse   231 IVYISEQAGVLLRCKRDVFRGARFSELLAPQDVGVFYGSTTPSRLPTWGTGTSAGSGLKDFTQEK 295

  Fly   309 STFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNG--TNMLLVICAT 371
            |.||    |.||......|     ..|:||||      .|...:   ..||:|  .....::.|.
Mouse   296 SVFC----RIRGGPDRDPG-----PRYQPFRL------TPYVTK---IRVSDGAPAQPCCLLIAE 342

  Fly   372 PIKSSYKV----PDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHED 432
            .|.|.|:.    ||:.:      |..|||.:.:...||..|...||||||||:|..::.|.|.||
Mouse   343 RIHSGYEAPRIPPDKRI------FTTRHTPSCLFQDVDERAAPLLGYLPQDLLGAPVLLFLHPED 401

  Fly   433 LSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQ 497
            ..:|...::.::   |.||..|...|.||..:||.||.::|.|..||:|||||:.||:|.|:|..
Mouse   402 RPLMLAIHKKIL---QLAGQPFDHSPIRFCARNGEYVTMDTSWAGFVHPWSRKVAFVLGRHKVRT 463

  Fly   498 GPKQCNVF-EAAPTCKLKISEEAQSRNTRIKEDIVKRL--------------------------- 534
            .|...:|| ..||:....:..:.|..:.:|...:::.:
Mouse   464 APLNEDVFTPPAPSPAPSLDSDIQELSEQIHRLLLQPVHSSSPTGLCGVGPLMSPGPLHSPGSSS 528

  Fly   535 ------AETVSRPSDTVKQEVSR-----RCQALASFMETLMDEVSRADLKLELPHENELTVSERD 588
                  ||....|:....|::.:     :.|....|:|:......|..|......:.::...:..
Mouse   529 DSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLFIESRAKPPPRPRLLATGTFKAKVLPCQSP 593

  Fly   589 SVMLGEISPHHDYYDSKSSTETPP-------SYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPP 646
            :..| |::|..|......:.|.|.       ||.|:|..:::||:..|..:            |.
Mouse   594 NPEL-EVAPVPDQASLALAPEEPERKETSGCSYQQINCLDSILRYLESCNI------------PS 645

  Fly   647 EPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTG 711
            ..:..|.|.:|...|        |.|..:...|..:.:.:..:.|.|...|.|.........| |
Mouse   646 TTKRKCASSSSYTAS--------SASDDDKQRAGPVPVGAKKDPSSAMLSGEGATPRKEPVVG-G 701

  Fly   712 T-------GTGTGTGTGTGTGTGTGTGTGTGTGNGTNS---------GTGTGTASSSKGGSAAIP 760
            |       .......:.|...:.:.|....|......|         |...|.|.|........|
Mouse   702 TLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMMEDLPGLAPGPAPSPAPSPTVAP 766

  Fly   761 --------PVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKMLEYSGPG--HG- 814
                    ||.||:::|:.|..:.|:..|.:.|:.....|..:...|.        |.||  ||
Mouse   767 DPTPDAYRPVGLTKAVLSLHTQKEEQAFLNRFRDLGRLRGLDTSSVAP--------SAPGCHHGP 823

  Fly   815 IKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPE 879
            |..|..|....:|.:.:.
Mouse   824 IPPGRRHHCRSKAKRSRH----------------------------------------------- 841

  Fly   880 GRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVH 944
             ....|....||                  ..|...:|.|||.|        |||      ||..
Mouse   842 -HHHQTPRPETP------------------CYVSHPSPVPSSGP--------WPP------PPAT 873

  Fly   945 STHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTD----MPTTSQQAAAAAA 1005
            :...||.|               |..|    |..|||       ||..    .||:...|...:.
Mouse   874 TPFPAMVQ---------------PYPL----PVFSPR-------GGPQPLPPAPTSVSPATFPSP 912

  Fly  1006 QAMPLQYMAGVMYPH------PSLFY---THPAAAAATAMMYQPMPFPGMANALQIPERPLGSQS 1061
            ...|   |..::.|:      ||..|   ..|.....|...:.|.|        .:|..||....
Mouse   913 LVTP---MVALVLPNYLFPTPPSYPYGVSQAPVEGPPTPASHSPSP--------SLPPPPLSPPH 966

  Fly  1062 AYNKSVYTTTPASMTKKVPGAFHSVTTPAQV------QRPSSQSASVKTEPGSSAAVSDPCKKEV 1120
            ..:..::.:..:|              |.|:      :.|.::..:....|||||....|.::..
Mouse   967 RPDSPLFNSRCSS--------------PLQLNLLQLEESPRTEGGAAAGGPGSSAGPLPPSEETA 1017

  Fly  1121 PDSSPIPSVMGDYNSDPPCSSSN------PANNKKYTDS-------------NGNSDDMDG---- 1162
            ...:.:..|....|.|....||:      ..:::..|.|             :|:.....|
Mouse  1018 EPEARLVEVTESSNQDALSGSSDLLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSA 1082

  Fly  1163 ----SSFSSFYSSFIKTTDGSESPPDTEK---DPKHRKLKS---------MSTSESKIM---EHP 1208
                ||.||..|.:..:.|.||:.....:   :|..:.:|.         |:.::.::|   :.|
Mouse  1083 SITRSSQSSHTSKYFGSIDSSEAEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQVP 1147

  Fly  1209 EED 1211
            ..|
Mouse  1148 SRD 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	27/101 (27%)
		PAS	238..>300	CDD:238075	14/65 (22%)
		PAS	388..495	CDD:238075	45/106 (42%)
		PAS_11	391..495	CDD:291273	45/103 (44%)
Per1	NP_001152839.1	Interaction with BTRC. /evidence=ECO:0000250\|UniProtKB:O15534	1..151		29/172 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		25/107 (23%)
		IMUP	6..>59	CDD:374086	6/25 (24%)
		Nuclear export signal 1. /evidence=ECO:0000250\|UniProtKB:O54943	138..147		3/19 (16%)
		PAS_3	373..457	CDD:369881	39/86 (45%)
		Nuclear export signal 2. /evidence=ECO:0000269\|PubMed:11591712	489..498		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..544		3/35 (9%)
		Required for phosphorylation by CSNK1E	596..815		48/248 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..698		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..772		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..873		24/151 (16%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:10848614	824..840		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..1037		20/120 (17%)
		Nuclear export signal 3. /evidence=ECO:0000250\|UniProtKB:O54943	981..988		1/6 (17%)
		LXXLL	1042..1046		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1051..1099		9/47 (19%)
		Period_C	<1082..1223	CDD:371905	14/69 (20%)
		CRY binding domain	1148..1291		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1207..1291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847107
Domainoid	1	1.000	90	1.000	Domainoid score	I7747
eggNOG	1	0.900	-	-		E1_KOG3753
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4096
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.980