Protein Alignment per and per2

DIOPT Version :9

• Sequence 1: NP_001259194.1
• Gene: per / 31251
• FlyBaseID: FBgn0003068
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_021334311.1
• Gene: per2 / 140633
• ZFINID: ZDB-GENE-011220-2
• Length: 1418
• Species: Danio rerio
• Alignment Length: 1395
• Identity: 291/1395 - (20%)
• Similarity: 473/1395 - (33%)
• Gaps: 404/1395 - (28%)

  Fly     2 EGGESTE----STHNT-KVSDSAYSNSCSNSQSQRSGS------SKSRLSGSHSSGSSGYGGKPS 55
            ||.:|::    |.||| |:|.|.:.:....|.|..|||      ::|..:.||.:.|.|.....|
Zfish    47 EGSDSSQDRPTSGHNTRKMSHSLHEDVEMKSSSGSSGSGTESHGNESHGNESHGNESHGNESSGS 111

  Fly    56 TQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICR 120
            :.:.|.|..:..:...::....:..:...:..|.:|:|||:       |:..||.:||
Zfish   112 SNSRSKDSALLVSSGSNKSSNSHSPSPPSSTNAFSLLSASS-------EQDNPSTSGC------- 162

  Fly   121 ELQDQQHGEDHSEPQAIEQLQQ-----EEEEDQSGSESEA-----DRVEGVAKSEAAQSFPIPSP 175
              ..::..:..::.:.|:.|::     ..|:...||:|..     ..:..|.:.||.:.:
Zfish   163 --SSEESAKAKTQKELIKTLKELKLHLPAEKRNKGSKSTTLNTLKYALRCVRQVEANEEY----- 220

  Fly   176 LSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSF 240
            ..:.::..|.            .|||.....|.|    :::|:|......          ..|.|
Zfish   221 YQLLMINDSQ------------PSGLDVSSYTIE----EIDSITSEYTLK----------NTDIF 259

  Fly   241 CCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQIT----------TGIP 295
            ...:|:..|.::|.:.....:|...||::....|::|:..:|.:.|.|..|          ||
Zfish   260 AVAVSLITGKIVYISDQAASILNCKRDVFKNAKFVEFLTPQDVSVFYSFTTPYRLPSWSMCTG-- 322

  Fly   296 IAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSN 360
             |:|..|.....||.||.:        ||| ......:.|.|||:.....:..:       |..:
Zfish   323 -ADSSPSDCMQEKSFFCRI--------SGG-KECEADLQYYPFRMTPYLMKVQD-------MEHS 370

  Fly   361 GTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIM 425
            ......::.|..:.|.|:.| .|.:.|. .|...||.:.:...||..||..||||||||||..::
Zfish   371 EDQFCCLLLAERVHSGYEAP-RIPTDKR-IFTTTHTPSCVFQDVDERAVPLLGYLPQDLIGTPVL 433

  Fly   426 DFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVV 490
            ...|..|...|...:..::   |.||..| ....||..:||.|:.::|.|:|||||||||:.||:
Zfish   434 LHLHPNDRPTMLGIHRKIL---QCAGQPF-DHSIRFCARNGEYITIDTSWSSFVNPWSRKVSFVI 494

  Fly   491 GHHRVFQGPKQCNVFEAAPTCKLKI---------------------------------------- 515
            |.|:|..||...:||.|..|.:.|.
Zfish   495 GRHKVRMGPVNEDVFAAPATAEGKCVDSDIQDITEQIHRLLLQPVHNNGSSGYGSLGSNDHLLSV 559

  Fly   516 --SEEAQSRNTRIK---EDIVKRLAETVSRPSDTVKQEVSRRCQALAS---FMETLMDEVSRADL 572
              |.|:....||.:   |||.|....:.......|..:.::..|:..|   |::  ...|.|
Zfish   560 ASSSESNGNGTRQRHEEEDIRKAKPRSFQEICKGVHMQKNQELQSKKSPTKFVQ--KSPVVR--- 619

  Fly   573 KLELPHENELTVSERDS--VMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNS--KPVT 633
                |.::...|:.|:|  .....:.....:.|     :|..||.|::..::::|:..|  .|:|
Zfish   620 ----PKDSAYPVNWRESQEEQRAAVQEELAFKD-----QTVYSYQQISCLDSVIRYLESCNVPIT 675

  Fly   634 APAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGT 698
            .              :..|.|.::...|...|....:..|....:....|:...:..|.......
Zfish   676 V--------------KRKCQSSSNTTSSNSDEDKQRNADSSMQVSEEPAHLKEQSGLSTLEVSKK 726

  Fly   699 GTGTGTGTGTGTGTGTGT---GTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGT------------ 748
            ..|:|..:.:.|.....:   ...:.|...:.:.|....|.....:|.....|
Zfish   727 PPGSGVVSPSLTPLALPSKPESVVSITSQCSYSSTIVHVGDKKVVSSTRHISTKQEYSSKLQKII 791

  Fly   749 --ASSSKGGSA---AIPPVT---------------LTESLLNKHNDEMEKFMLKKHRESRGRTGE 793
              ..|::|...   |:||..               ||:.:|..|..:.|:..|.:.||.|
Zfish   792 EDVPSAEGTDVQGLAVPPAAVSPQNQEREAYKKLGLTKQVLAAHTQKEEQAFLSRFRELR----- 851

  Fly   794 KSKKSANDTLKMLEYSGPGHGIKRGGSHSWEGEAN----KPKQQLTLGTDAIKGAAGSAGGAVGT 854
                                     |.|:::.:.:    :.|.|:|  ::|:..|.....|
Zfish   852 -------------------------GVHAFKADCSLYLERQKGQVT--SEAVPAARSCKAG---- 885

  Fly   855 GGVGSGGAGVAGGGGSGTGVAGTPEGRATTT---------SGTGTPGGAGGGGGAGAAAAAGASS 910
                       |||...|  ..|..||...|         |...||.|.
Zfish   886 -----------GGGAQET--TTTRRGRNKKTKSKRVKPNESSDSTPSGR---------------- 921

  Fly   911 SVGSSTPGPSSYPTCTQNIN--LWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTP 973
                   .|:..|. .|.:|  .|.|                   |.:|...||..|  || :.|
Zfish   922 -------RPAHRPQ-LQGLNQTSWSP-------------------SDTSQSTFPIAY--PA-VMP 956

  Fly   974 TSPTRSPRMHKHPHKGG----TDMPT----TSQQAAAAAAQAMPLQ--YMAGVMYPHPSLF---Y 1025
            ..|     :..:|..||    .|.|.    .||.|........|:|  |.|.::.|..:|.   |
Zfish   957 AYP-----LQMYPGAGGMQPRVDPPMPGFGESQCAPDPRIPMQPIQTPYSAPLVTPMVALVLPNY 1016

  Fly  1026 THPAAAAATAMMYQPM---PFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVT 1087
            ..|...:|....:.|.   |||              :|..:......|..||..   |.:..::.
Zfish  1017 MFPQVGSAPRQAFYPPKQGPFP--------------TQPTFQTQPGFTPQASFP---PQSTFTIQ 1064

  Fly  1088 TPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPD------SSPIPSVMGDYNSDPP-------- 1138
            |....|.|.|...:.:.:|...|...||.|...|:      .||.|..||  ...||
Zfish  1065 TQFTSQNPFSSQPTFQPQPFPFACPEDPPKAPEPELREEQSRSPTPQSMG--GGGPPSPPLFQSR 1127

  Fly  1139 CSSSNPANNKKYTDSNGNSDDMDGSSFSSF-----------------YSSFIKTTDGSESPPDTE 1186
            |||....|..:..::..::|..:.::.|:.                 .|..:|.....|..|
Zfish  1128 CSSPLQLNLLQLEETQRSADRQENTAPSAVPLNNCSTGVEKAGSVTAQSKPVKDVVQDEGSP--- 1189

  Fly  1187 KDPKHRKLKSMSTSESKIMEHPEEDQTQHG 1216
            .|.:|....|.|:....|:  ||:.::..|
Zfish  1190 VDGQHSDALSSSSDLLDIL--PEDSRSGTG 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	26/104 (25%)
		PAS	238..>300	CDD:238075	17/71 (24%)
		PAS	388..495	CDD:238075	44/106 (42%)
		PAS_11	391..495	CDD:291273	44/103 (43%)
per2	XP_021334311.1	PAS_3	399..499	CDD:330807	44/103 (43%)
		Atrophin-1	<880..1111	CDD:331285	66/315 (21%)
		Period_C	1208..1382	CDD:314915	3/12 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592321
Domainoid	1	1.000	83	1.000	Domainoid score	I8273
eggNOG	1	0.900	-	-		E1_KOG3753
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4269
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11269
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3625
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.010