Protein Alignment per and per2

DIOPT Version :9

• Sequence 1: NP_001259194.1
• Gene: per / 31251
• FlyBaseID: FBgn0003068
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_012825562.2
• Gene: per2 / 100151702
• XenbaseID: XB-GENE-486306
• Length: 1420
• Species: Xenopus tropicalis
• Alignment Length: 1407
• Identity: 294/1407 - (20%)
• Similarity: 489/1407 - (34%)
• Gaps: 438/1407 - (31%)

  Fly     5 ESTESTHNTK-VSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGG-KPSTQASSSDMI--I 65
            |.|||..|.| :::.:.|:.||.|.|. :..|.......|:..:|||.. :|..:.:..|::  :
 Frog   151 EVTESDENGKELAEKSCSDICSPSCSS-NAFSLMMADTEHNPSTSGYSSEQPDKEKTQKDLLKML 214

  Fly    66 KRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGED 130
            |..:......|:|:.                           .|||....:.....:|..|..|:
 Frog   215 KELRSHLPPDKRNRS---------------------------KSGTAAALKYALHCIQQVQANEE 252

  Fly   131 HSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAA 195
            :      .||.....|...|.|:....|:
 Frog   253 Y------YQLLMVNGEQPCGLEASCYSVQ------------------------------------ 275

  Fly   196 GLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITD 260
                              ::|::|          ....|...|.|...:|:..|.::|.:...:.
 Frog   276 ------------------EIENIT----------SEYTRNNTDMFAVAVSLVTGRIVYISEQASV 312

  Fly   261 VLGYPRDMWLGRSFIDFVHLKDRATFASQITT-GIPI------AESRGSVPKDAKSTFCVMLRRY 318
            ||....||:....|::.:..:|...|.|..|. .:|.      |:|......:.||.:|   |..
 Frog   313 VLRCGPDMFSQIRFVELIAPQDVNVFYSSTTPYRLPSWNICCGADSSYVDSMEEKSFYC---RVS 374

  Fly   319 RGLKSGGFGVIGRPVSYEPFRLG--LTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPD 381
            .|.:|      .:.|.|.|||:.  |.:.:..|.|:         ..:..|:.|..:.|.|:.|
 Frog   375 CGRES------RKEVVYHPFRMTPYLIWVKTEETAK---------EQLCCVLFAERVHSGYEAP- 423

  Fly   382 EILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKK 446
            .|.:.|. .|...||.:.:...:|..||..||||||||||.|||...|.:|..:|...::.:::.
 Frog   424 RIPADKR-IFTTTHTPSCLFQDIDERAVPLLGYLPQDLIGSSIMLHLHPKDRPLMLAVHKKILQY 487

  Fly   447 GQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTC 511
            |   |..|...|.||..:||.|:.::|.|:||:||||||:.|::|.|:|..||...:||.|.|
 Frog   488 G---GQPFDFSPIRFCARNGEYITIDTSWSSFINPWSRKVSFIIGRHKVRMGPVNEDVFAAPP-- 547

  Fly   512 KLKISEEAQSRNTRIKEDIVKRLAETVSRP---------------------------SDT---VK 546
                ..|.:|.:..|:| :.:::...:.:|                           ||:   ..
 Frog   548 ----HTEDKSLHPGIQE-LTEQIYHLLMQPVHNSNSSGYGSLGSNGSHENPMSAASSSDSNGNAN 607

  Fly   547 QEVSRR---CQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLG---EISPH-HDYYDS 604
            :::..:   ||      |.|.:|.|.|   .:...:.:||    .:|::|   :.||. .||...
 Frog   608 EDIKDKNVACQ------ELLGEEHSTA---FQDKEKQKLT----KNVLIGRHTDNSPSTRDYSKD 659

  Fly   605 --KSSTETPP---------------SYNQLNYNENLLRFFNS--KPVTAPAELD----------- 639
              |:|.::.|               ||.|::..::::|:..|  .|.::.::.|
 Frog   660 VIKASPDSGPCPIQSEDLPAKQHPYSYQQISCLDSVIRYLESCGVPTSSKSKWDSSGYKETSSSH 724

  Fly   640 ----PP---------------KTEPPEPRGT-CVS-------GASGP-MSPVHEGSG---GSGSS 673
                ||               :|.|..|..| |.|       .:||| :|||.|...   ...:.
 Frog   725 TDHNPPQHQKAKLNKDNQAMLETLPKLPNCTMCPSVKLMSQASSSGPCISPVTEVQSTLCSLQAP 789

  Fly   674 GNFTTASNIHMSSVTNTSIA--------GTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT 730
            .:.....::..:|:|:.::|        ..|.......:.|...:.:.|....|...........
 Frog   790 RSLPAQGSLPCTSLTSIAVAPCPALTPLSLGAKAESVVSFTSHCSYSSTIVHVGDKKLQPETEME 854

  Fly   731 GTGTGTGNGTNSGTGTGTASSSKGGSAAIPPVTLTESLLNKH-----NDEMEKFM-LKKHRESRG 789
            ...:..|:.|       ..|:|.........:.||:.:|..|     ||.:..|| :||....:.
 Frog   855 DCPSALGDPT-------PVSASVAEKEPYRQMGLTKEVLAAHTQKEENDFLTGFMDIKKLSAFQA 912

  Fly   790 RTGEKSKKSANDTLKMLEYSG-PGHGIKRGGSHSWE--GEANKPKQQLTLGTDAIKGAAGSAGGA 851
            |        .|..|:  |..| |.....:|...||:  |:..|||      |..::
 Frog   913 R--------CNSYLQ--ERPGAPRTRRAQGPDTSWKRTGKTRKPK------TKRVR--------- 952

  Fly   852 VGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGT------GTPGGAGGGGGAGAAAAAGASS 910
                                      ||...:::||.      ..|         |....|.:.|
 Frog   953 --------------------------PESWDSSSSGAHDAPRHPLP---------GLNTTAWSQS 982

  Fly   911 SVGSSTPGPSSYPTCTQNINLWPPFSVGITP----PVHSTHTAMAQSSFSS------AGLFPTF- 964
            ....::..|..||       :.|.:.:.:.|    || ...||...|:.:|      |.|.|..
 Frog   983 DASHASYPPLPYP-------VLPAYPLPVFPSPQIPV-PNETAQIPSANASTPQPFPAPLLPPMV 1039

  Fly   965 ------YYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQ--------AMPLQY--- 1012
                  |..||||..|.....|.....|.:..:.:|    |:...|||        |..||.
 Frog  1040 ALVLPNYMYPASLPTTLYPGPPSQPAFPAQPNSYLP----QSTFPAAQPTFPVPGPAFSLQQPNF 1100

  Fly  1013 -MAGVMYPHPSLFYTHPAAAAATAMMYQPM----PFPGMANALQIPERPLGSQSAYNKSVYTTTP 1072
             :|..::|.|.      .|.:....:|.|.    |||....:..||...|.::...::|.....|
 Frog  1101 TVAQPVFPTPQ------NALSVLPPLYTPQPVQNPFPAQPVSFPIPAPTLKTKEGISRSSTPQEP 1159

  Fly  1073 ASMTKKVPGAFHS-VTTPAQ-----------VQRPSSQSASVKTEPGSSAAVSDPCKK------- 1118
            .|     |..|.| .::|.|           |..|...|.......|:|:.:..|...
 Frog  1160 PS-----PPLFQSRCSSPLQLNLLQLEETQKVDHPEGNSGCTDKGGGNSSVLVKPSDDSQLHLSR 1219

  Fly  1119 -----EVPDSSPIPS-------VMGDYNSDPPCSSSNPANNKKYTDSNGN--SDDMDGSSFSSFY 1169
                 :.|:|..:.:       ::.:..|...||:|:..::...:.|:||  |....|||.:|..
 Frog  1220 AASPVDAPNSDAMSTCSDLMDLLLRENASSGTCSASSAISDSMTSGSHGNGTSGSQTGSSLTSRS 1284

  Fly  1170 SSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEHPEED 1211
            |.:..:.|.||       :.:|...::.|:....||::..:|
 Frog  1285 SKYFGSVDSSE-------NKEHGGQETGSSRSKSIMKYVLQD 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
per	NP_001259194.1	PAS	238..333	CDD:279347	23/101 (23%)
		PAS	238..>300	CDD:238075	16/68 (24%)
		PAS	388..495	CDD:238075	44/106 (42%)
		PAS_11	391..495	CDD:291273	44/103 (43%)
per2	XP_012825562.2	PAS_11	432..533	CDD:405306	44/103 (43%)
		PHA03247	<920..1167	CDD:223021	66/319 (21%)
		Period_C	1228..1398	CDD:403366	22/99 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7862
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3794
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48299
Panther	1	1.100	-	-	O	PTHR11269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060