DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2652 and YEATS4

DIOPT Version :9

Sequence 1:	NP_570015.1	Gene:	CG2652 / 31250	FlyBaseID:	FBgn0025838	Length:	235	Species:	Drosophila melanogaster
Sequence 2:	NP_006521.1	Gene:	YEATS4 / 8089	HGNCID:	24859	Length:	227	Species:	Homo sapiens

Alignment Length:	171	Identity:	41/171 - (23%)
Similarity:	76/171 - (44%)	Gaps:	22/171 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WGVYLRPGRDGGDLSRFVRRVTFKMSPRLPLRLHVADSAPFEIGEVLGSDFPVEVQVQYMDARMS 124
            |.||::|.|: .|:|.:|:::.||:.......|.|....|:||.|....:|.:.:::.::|....
Human    47 WTVYVKPYRN-EDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNER 110

  Fly   125 ATSYIFRPRVVRE------GHAGICEEMLDKMIFVNPSPMMRQNLTPVLVPSANGAPGDRTSPQF 183
            ..:.....::.:.      |...:..|..|:|||.:|:.||:|.||              ||.|.
Human   111 PVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLT--------------TSRQL 161

  Fly   184 AMESAMPETPGERKEQDRDREQVGDVARPSQPPAKQPKKRL 224
            .:.:...||.....|. :.||::....:.:.....:.|:||
Human   162 TLGAYKHETEFAELEV-KTREKLEAAKKKTSFEIAELKERL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2652	NP_570015.1	YEATS	26..>120	CDD:303059	17/59 (29%)
YEATS4	NP_006521.1	YEATS_GAS41_like	19..155	CDD:341128	28/108 (26%)
		Diacetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:29900004, ECO:0000269\|PubMed:30071723, ECO:0007744\|PDB:5VNB, ECO:0007744\|PDB:5XTZ	93..97		0/3 (0%)
		Interaction with MLLT10. /evidence=ECO:0000269\|PubMed:11756182	163..227		8/40 (20%)
		Interaction with TACC1. /evidence=ECO:0000269\|PubMed:11903063	168..227		8/35 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S932
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760