DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2652 and MLLT3

DIOPT Version :9

Sequence 1:	NP_570015.1	Gene:	CG2652 / 31250	FlyBaseID:	FBgn0025838	Length:	235	Species:	Drosophila melanogaster
Sequence 2:	NP_004520.2	Gene:	MLLT3 / 4300	HGNCID:	7136	Length:	568	Species:	Homo sapiens

Alignment Length:	218	Identity:	42/218 - (19%)
Similarity:	71/218 - (32%)	Gaps:	41/218 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CVISRDIVIGCRMEQCDPDMPYMLEPT-------WGVYLRPGRDGGDLSRFVRRVTFKMSPRLPL 90
            |.:...:.:|.|.:       ...:||       |.|::| |.:..::..||.:|.|.:....|.
Human     5 CAVQVKLELGHRAQ-------VRKKPTVEGFTHDWMVFVR-GPEHSNIQHFVEKVVFHLHESFPR 61

  Fly    91 RLHVADSAPFEIGE--VLGSDFPVEVQVQYMDARMSATSYIFRPRVVR---------EGHAGICE 144
            ...|....|:::.|  ..|...|:||..:..:          .||.||         |||..:..
Human    62 PKRVCKDPPYKVEESGYAGFILPIEVYFKNKE----------EPRKVRFDYDLFLHLEGHPPVNH 116

  Fly   145 EMLDKMIFVNPSPMMRQNLTPVLVPSANGAPGDRTSPQFAMESAMPETPGERKEQDRDREQVGDV 209
            ...:|:.|.||:...|:.|.     .|.|.|........:..|:...:.................
Human   117 LRCEKLTFNNPTEDFRRKLL-----KAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSS 176

  Fly   210 ARPSQPPAKQPKKRLSVGIPHPI 232
            :..|...:.......|...||.:
Human   177 SSSSSSSSSSSSSSTSFSKPHKL 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2652	NP_570015.1	YEATS	26..>120	CDD:303059	21/95 (22%)
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	33/150 (22%)
		Inhibitor XL-07i binding. /evidence=ECO:0000269\|PubMed:30374167, ECO:0007744\|PDB:5YYF	56..58		0/1 (0%)
		Histone H3K9cr binding. /evidence=ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:30385749, ECO:0007744\|PDB:5HJB, ECO:0007744\|PDB:5HJD, ECO:0007744\|PDB:6MIL, ECO:0007744\|PDB:6MIM	78..80		0/1 (0%)
		Inhibitor XL-07i binding. /evidence=ECO:0000269\|PubMed:30374167, ECO:0007744\|PDB:5YYF	106..109		0/2 (0%)
		Histone H3K9cr binding. /evidence=ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:30385749, ECO:0007744\|PDB:5HJB, ECO:0007744\|PDB:5HJD, ECO:0007744\|PDB:6MIL, ECO:0007744\|PDB:6MIM	106..108		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..475		8/63 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300
		AHD	503..563	CDD:375335
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810