Protein Alignment HLH3B and TWIST1

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_000465.1
• Gene: TWIST1 / 7291
• HGNCID: 12428
• Length: 202
• Species: Homo sapiens
• Alignment Length: 160
• Identity: 57/160 - (35%)
• Similarity: 79/160 - (49%)
• Gaps: 27/160 - (16%)

  Fly    82 SDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRSHSRNGLLTAPASSGSSVGGS------- 139
            :|.||:::||:.:..:......|     .|...||.|  |..|......::|..|||.
Human    13 ADDSLSNSEEEPDRQQPPSGKRG-----GRKRRSSRR--SAGGGAGPGGAAGGGVGGGDEPGSPA 70

  Fly   140 -----------GGGGGNGSGGNASSGGGSGVGATG-GVRKVFTNTRERWRQQNVSGAFAELRKLV 192
                       |||||.|.||.:||||||...... ..::|..|.|||.|.|:::.|||.|||::
Human    71 QGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKII 135

  Fly   193 PTHPPDKKLSKNEILRSAIKYIKLLTGILE 222
            ||.|.| ||||.:.|:.|.:||..|..:|:
Human   136 PTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	27/57 (47%)
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		30/98 (31%)
		bHLH_TS_TWIST1	98..174	CDD:381418	29/68 (43%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		1/4 (25%)